ABSTRACT Introduction: Oral submucous fibrosis (OSMF) is a potentially malignant disorder characterized by fibrotic changes in the oral mucosa. It is a significant public health concern, particularly among certain ethnic populations. The Gond tribes of Central India represent one such population, and the prevalence and risk factors associated with OSMF among them remain largely unexplored. This study aims to conduct a predictive risk factor analysis to identify the factors associated with OSMF among the Gond tribes and provide insights into the etiology and pathogenesis of the disease within this specific population. Materials and Methods: A cross-sectional study was conducted among the Gond tribal population of Central India. A total of 800 participants were included in the study. Oral examinations were conducted by trained researchers to assess the presence of OSMF and other oral health conditions. Demographic and socioeconomic data were collected, including age, gender, education level, occupation, and household income. Lifestyle factors such as tobacco and betel nut chewing, alcohol consumption, and oral hygiene practices were assessed through structured questionnaires. Dietary patterns and nutritional status were evaluated, and oral health-related factors such as dental caries, periodontal health, and other oral lesions were examined. Multivariate analysis was performed to identify independent risk factors associated with OSMF among the Gond tribes. Results: The prevalence of OSMF among the Gond tribes was 12.5%. Demographic analysis revealed a balanced representation of genders, with a range of age groups included. Lifestyle factors such as tobacco and betel nut chewing were prevalent among the Gond tribes, with a significant proportion of participants reporting regular use of these substances. Poor oral hygiene practices and undernutrition were also identified as risk factors. Dietary patterns showed a high consumption of carbohydrate-rich foods and a relatively low intake of fruits and vegetables in addition to OSMF. Conclusion: This study provides valuable insights into the prevalence and risk factors associated with OSMF among the Gond tribes of Central India. The findings highlight the need for targeted interventions addressing tobacco and betel nut chewing, poor oral hygiene practices, advanced age, low education level, and undernutrition within this population. Comprehensive oral health promotion programs, including tobacco cessation initiatives, oral hygiene education, nutritional interventions, and improved access to dental care, are crucial for reducing the prevalence of OSMF and improving oral health outcomes among the Gond tribes. Future research should focus on longitudinal studies to further elucidate the causal relationships and long-term impact of these risk factors on the development and progression of OSMF within the Gond tribal population.