To improve the stability and accuracy of quintic polynomial trajectory tracking, an MPC (model predictive control) and fuzzy PID (proportional‐integral‐difference)‐ based control method are proposed. A lateral tracking controller is designed by using MPC with rule‐based horizon parameters. The lateral tracking controller controls the steering angle to reduce the lateral tracking errors. A longitudinal tracking controller is designed by using a fuzzy PID. The longitudinal controller controls the motor torque and brake pressure referring to a throttle/brake calibration table to reduce the longitudinal tracking errors. By combining the two controllers, we achieve satisfactory trajectory tracking control. Relative vehicle trajectory tracking simulation is carried out under common scenarios of quintic polynomial trajectory in the Simulink/Carsim platform. The result shows that the strategy can avoid excessive trajectory tracking errors which ensures a better performance for trajectory tracking with high safety, stability, and adaptability.