Canalicular adenoma is an uncommon benign salivary gland tumor that mostly occurs in the upper lip, may present multiple nodules, and can involve multifocal microscopic growth. The microscopic appearance can be mistaken for a polymorphous low-grade adenocarcinoma or basal cell adenoma. Immunohistochemistry can be helpful in differentiating these disorders. Two cases of canalicular adenoma showing tumor foci are described. Both occurred in the upper lip of white women aged 72 and 79 years, respectively. Besides the histological multifocal aspect, one patient had bilateral nodules. Histological examination of lesions revealed interconnecting and branching canal-like structures composed of uniform columnar and sometimes cuboidal cells that were partially encapsulated. Immunohistochemical analysis showed intense expression of cytokeratins 7 and 13, weak reaction to 14, and a negative reaction to vimentin. Once they were diagnosed, the lesions were excised. It is important to properly diagnose canalicular adenoma and differentiate its multifocal aspect from malignant behavior.