Abstract

Adenoid cystic carcinoma (ACC) represents approximately 10-15% of salivary gland malignancies and almost universally exhibits a lethal clinical course. ACC is composed of a dual cell population (ductal and myoepithelial cells) and may demonstrate tubular, cribriform, and/or solid architectural patterns. Unfortunately, these histopathologic features are not specific to ACC and can be seen in other salivary gland neoplasms: basal cell adenoma, basal cell adenocarcinoma, epithelial-myoepithelial carcinoma, polymorphous low-grade adenocarcinoma, and adenocarcinoma not otherwise specified (NOS).

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