Polymeric Quaternary Ammonium Salts Research Articles

Ion Exchange Resins Anchoring 1,8-Diazabicyclo[5.4.0]undec-7-ene

Abstract The synthesis of polymeric quaternary ammonium salts linked 1,8-diazabicyclo[5.4.0]undec-7-ene(DBU) to chloromethylated polystyrenes is described. The polymers so obtained become anion exchangers with both quaternary ammonium and tertiary amino groups. The values of the total ion-exchange capacities indicated that the quaternization of the tertiary amino groups on the polymers with hydrochloric acid is difficult. The chloride forms of the resins, in spite of their bulky and steric quaternary ammonium groups containing DBU, were effective as ion exchangers for a variety of bulky anions such as sulfate, oxalate, hexacyanoferrate(II), hexacyanoferrate(III), and tris(oxalato) ferrate(III) ions. The free base forms of the resins gave low reactivity for chloride and sulfate ions. Some examples of the application of the resins is also reported.

Polymer-polymer complexes with the participation of synthetic polyampholites

Potentiometry and turbidimetry were used in a study of complexes of copolymers of 2-methyl-5-vinylpyridine and acrylic acid with a model polyanion (polyacrylic acid) and a model polycation (a polymeric quaternary ammonium salt, ionene-5,6). It was found that H bonds make a major contribution to cooperative stabilization of the resulting polycomplexes. Synthetic polyampholites are capable of cooperative bonding with both anionogenic and cationogenic macromolecules, i.e. the polymers in question differ markedly from the homopolymers by reason of their broad cooperative interaction spectra.

Synthesis and antimicrobial properties of monomeric and polymeric quaternary ammonium salts based on aminoalkyl esters of methacrylic acid

Synthesis and antimicrobial properties of monomeric and polymeric quaternary ammonium salts based on aminoalkyl esters of methacrylic acid

Polyelectrolyte complexes based on polymeric quaternary ammonium salts

Potentiometric titration and optical rotatory dispersion were used in a study of the formation of polyelectrolyte complexes of polyacrylic (PAA) and poly- l-glutaminic (PGA) acids with a number of ionenes differing as to charge distribution along the chain. It is shown that the chemical structure of an ionene has a major effect on the way in which reactions between polyelectrolytes take place. In addition it was found that in some of the ionenes the composition of thi polyelectrolyte complexes varies in the initial stages of the reaction. The formation of polyelectrolyte complexes was found to have a considerable effect on the conformation of PGA, and a conformation with optical properties corresponding to a statistical coil conformation becomes the stable conformation of PGA in a complex. For PGA in a complex with ionenes there is considerable displacement of the helix-coil transition into the acid region of pH. This displacement is inversely proportional to distance between ionene groups in the ionene chain.

Vinyl ethers containing the epoxy group

1. A number of vinyl (2-hydroxy-3-aminopropoxy)alkyl ethers was synthesized by the reaction of 1-(vinyloxyalkoxy)propylene 2,3-oxides with primary and secondary amines. 2. The reaction of the 1-(vinyloxyalkoxy)propylene 2,3-oxides with aqueous trimethylamine solution gives quaternary ammonium bases (choline derivatives), while reaction with methyl iodide gives polymeric quaternary ammonium salts. 3. The pharmacological testing of the obtained amines disclosed that they have hypotensive and spasmolytic action, lower the motive activity, and upset the coordination of motion.

The Polymerization of Pharmacophoric Moieties and Its Effect Upon Biologic Activity I. Polymeric Quaternary Ammonium Salts

A group of polymeric quaternary ammonium salts have been synthesized and studied pharmacologically. The polymers exhibited a high degree of neuromuscular blocking potency. The results have been discussed both in regard to their theoretic and practical importance. Such polymers exemplify the idea that multiplication of pharmacophoric moieties through polymerization may yield drug agents having very long durations of action.