Poly(organo)phosphazene polymer (PP) coated on metallic coronary stents induce a severe histiolymphocytic and fibromuscular reaction leading to major coronary stenosis 6 weeks after stent implantation in a porcine coronary model. PP coated stents were loaded with angiopeptin (AP) (5 wt %) and stent stenosis was evaluated using quantitative coronary analysis and histopathology. A total of 14 pigs (7 received an AP loaded stent, 7 a non AP loaded stent (NAP) were studied. Minimal luminal stent diameter (MLSD) was measured using a semi-automated edge detection algorithm (Polytron® 1000 Siemens) Pre stent implantation MLSD;APL:2.5 ± 0.2 mm; NAPL 2.6 ± 0.4 mm(NS). Post stent implantation MLSD:APL:3.0 ± 0.4 mm; NAPL 3.4 ± 0.3 mm (NS). After 6 weeks MLSD was significantly higher in the APL group compared with the NAPL group 2.2 ± 0.6 mm vs 1.7 ± 1.0 mm (p < 0.01). Histopathology demonstrated a severe histiolymphocytic and fibromuscular reaction in both groups but vessel narrowing was significantly more important in the NAPL group compared with the APL group (87.6 ± 11.5% vs 63.4 ± 18.2%; p < 0.01). These results suggest that local AP delivery using an AP loaded polymer coated stent is able to inhibit the foreign body reaction induced by poly(organo)phosphazene stent coatings.