Event Abstract Back to Event Multifunctional noncovalent polymer-gatekeeper in mesoporous silica nanoparticles as a drug delivery platform Ja-Hyoung Ryu1 1 Ulsan National Institute of Science and Technology, Department of Chemistry, Korea Nanoscopic delivery vehicles capable of encapsulating drug molecules and releasing them in response to external stimuli are of great interest due to implications in therapeutic applications. Block copolymer micellar assemblies are promising scaffolds to overcome many of the problems faced with traditional chemotherapies because of their capacity for non-covalent, hydrophobic guest molecule binding. However, the stability of encapsulation with such self-assembled systems is limited during blood circulation. Thus, deliberate molecular design for stable encapsulation, targeting and triggered release is required. For this purpose, we have developed a facile synthetic method for highly stable, polymeric nanogels or polymer-caged hollow nanoparticles using a simple intra/inter-chain crosslinking reaction. We show a simple method for the preparation of biocompatible nanovehicles that provides the ability to encapsulate hydrophobic or hydrophilic drug molecules. We can control the size of the nano-carriers and release kinetics depending on crosslinking in responsive to stimuli. Nano-carriers showed great stability to encapsulate drug molecules and drugs were only released inside cell via disulfide cleavage in responsive to intracellular reducing agent, GSH. Furthermore, we can use surface modified nano-carriers for target delivery system. Hence, the stimuli responsive nano-carrier formation using self-crosslinking polymers and the corresponding method of surface modification are a promising platform for a range of biomedical applications, from drug delivery to biosensing. This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean Government (Ministry of Education, Science and Technology, Grant No. NRF-2011–35B-C00024)