Abstract
ABSTRACTIn recent years, the polymeric nanogels, as a group of nanostructured materials, have attracted the attention of researchers of various fields such as polymers, materials science, pharmacy, and drug delivery. Gels are mostly known for their water-swellable features and are candidates for a variety of applications. In this work, a facile solvent free synthesis procedure for production of dextran-hydroxyethyl methacrylate (Dex-HEMA) and poly N-isopropyl acryl amide (PNIPAM) copolymeric nanogels is narrated. The polymerization process was conducted by the UV irradiation and the gel size was controlled by the liposomal structures. The H-NMR and FTIR analysis were all proved a successful polymerization procedure. By implication of the dynamic light scattering (DLS), the mean diameter of particles was determined to be in the range of ca. 350 nm. The molecular weight determination by the GPC results in the Mw ranging from 16100 to 20900 gr mol−1 with a polydispersity index of ca. 1.5. The turbidity assay indicated the thermosensitive nature of the gels and a LCST of ca. 32.5 was characterized. In this work, the equilibrium swelling measurements and the water content studies at two temperatures of 25 and 37°C were also performed.
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