Polyethylene Resins Research Articles

Tuning tear and slow crack growth resistance of linear low-density polyethylene resins through partial replacement of 1-butene with 1-hexene

The present study encompasses the utilization of a mixture of 1-butene and 1-hexene comonomers for the large-scale production of a film-grade linear low-density polyethylene (LLDPE) resin. The goal involves assessing the impact stemming from the partial replacement of 1-butene with 1-hexene on the thermal, physical, mechanical and rheological properties of the resultant resin, juxtaposed against an LLDPE counterpart exclusively produced by 1-butene as the comonomer. Although the comprehensive examination of key physical, thermal, rheological and mechanical characteristics indicates nominal influence due to the substitution, a marked escalation materializes in both the tear resistance and slow crack growth (SCG) resilience of the LLDPE resins formulated through the amalgamation of these comonomers. Specifically, the tear and SCG resistance of the proposed resin exhibit an extraordinary surge exceeding 60% and 30%, respectively. This discernible enhancement underscores the viability of the proposed technique as a propitious avenue for augmenting the requisite mechanical properties, obviating the need for an all-encompassing shift from 1-butene to longer-chain α-olefin comonomers.

Predicting High-Density Polyethylene Melt Rheology Using a Multimode Tube Model Derived Using Non-Equilibrium Thermodynamics.

Based on the Generalized bracket, or Beris-Edwards, formalism of non-equilibrium thermodynamics, we recently proposed a new differential constitutive model for the rheological study of entangled polymer melts and solutions. It amended the shortcomings of a previous model that was too strict regarding the values of the convective constraint release parameter for the model not to violate the second law of thermodynamics, and it has been shown capable of predicting a transient stress undershoot (following the overshoot) at high shear rates. In this study, we wish to further examine this model's capability to predict the rheological response of industrial polymer systems by extending it to its multiple-mode version. The comparison with industrial rheological data (High-Density Polyethylene resins), which was based on comparison with experimental data available in (a) Small Amplitude Oscillatory shear, (b) start-up shear, and (c) start-up uniaxial elongation, was noted to be good.

Performance comparison of semi‐conductive shielding layer for high‐voltage cable based on polypropylene and low density polyethylene resin

AbstractWith the concept of environmental protection is deeply popular, the power cables change from traditional thermosetting cross‐linked polyethylene (XLPE) cables to low‐carbon, environmentally friendly, recyclable polypropylene (PP) cables and the semi‐conductive shielding layer that matches the insulation layer for PP cables is highly valued. In this paper, LDPE is replaced with PP in the formulation of shielding layer of commercial XLPE cables. The physicochemical and electrical properties of PP/EVA/CB (PP‐based) and LDPE/EVA/CB (LDPE‐based) shielding layers were compared. The effect of interface matching characteristics on the electric field distortion was analyzed by finite element simulation software. The experimental results show that the volume resistivity of the shielding layers all tend to rise with the increasing temperature, but the resistivity of the PP‐based shielding layer has a smaller fluctuation. The PP‐based shielding layer has a smoother surface, while the space charge injected into the PP insulation layer is the lowest, about 0.433 × 10−7 C. Compared to the LDPE‐based shielding layer/insulation layer, the PP‐based shielding layer/insulation layer has a 50% reduction in interfacial electric field distortion rate. This work is an essential reference for the development for PP cables and their shielding layer selection.

Investigating the thermal and mechanical properties of novel LDPE/TiO2 and LDPE/TiO2/CNT composites for 3D printing applications.

The development of new materials is essential for advancing technology and improving the quality of life. With new materials, we can create products that are stronger, more durable, and more efficient. The ongoing research and development of new materials for 3D printing applications continue to drive innovation in various fields, leading to improved products and processes with great benefits. The main goal of this work was to produce a functional filament with a 1.75-mm diameter that may be used for 3D printing. Composite materials were prepared using a low-density polyethylene (LDPE) resin as polymer matrix, and titanium dioxide (TiO2) and carbon nanotubes (CNT) as fillers in various ratios. Up to 15 wt% of TiO2 and 0.25 wt% of CNT were added. Some of the greatest difficulties with high filler content composites are achieving good homogeneity, and in the case of the 3D printing, greatest difficulties are producing the filament with a specific and stable filament diameter. During the 3D printing itself, the fillers can also often cause the nozzle clogging. This paper reports findings of thermal and mechanical properties of the LDPE/TiO2/CNT composites which are significant for the 3D printing process and the applicability of the composite materials. All of the planed composite materials are successfully prepared and 3D printed into the tensile test specimens. The melting point shift caused by the addition of fillers did not show consistent pattern at differential scanning calorimetry, as all of the samples had melting temperatures around 113.5 ± 1.4 °C. The addition of filler, according to the TGA, increased the threshold temperature for the material decomposition, in case of TiO2 5.4 °C increase, while TiO2 and CNT combination increased the threshold temperature for 6.8 °C. The results of the tensile test show a general increase trend with addition of TiO2 filler but do not show to a trend for the tensile strength as a result of the addition of CNT filler. The sample with highest TiO2 filler ratio of 15% (LDPE 15T0C) showed the greatest tensile strength of 14.5 MPa, compared to the 13.0 MPa of pure LDPE. The sample with 5% of TiO2 filler and 0.1% of CNT filler (LDPE 5T0.1C) showed the greatest elongation of 73.9%, compared to the 68.9% of pure LDPE.

Titanium dioxide microspheres modified with cobalt stearate as a photocatalyst for the degradation of polyethylene films

The degradation of plastics is of great importance due to the ever-increasing concerns of environmental issues. Herein, we report a photocatalyst for the degradation of polyethylene (PE) films, that is, nano titanium dioxide (TiO2) nanoparticles modified with cobalt stearate, which was prepared by sol-gel method and surface modification. Its structure, morphology, and thermal stability were studied by powder X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. Then the prepared photocatalyst was added to the linear low-density polyethylene (LLDPE) resin, resulting in a novel PE/TiO2 composite film. The effects of the modified TiO2 on the plasticity of PE film and the degradation performance of the composite film under UV irradiation were investigated. The mechanical properties, molecular weight change, and melting index (MFR) of the film were measured. The results revealed that the degradation properties of PE films were significantly improved after the addition of modified nano TiO2 microspheres. Under UV irradiation for 96 h, the tensile elongation retention rate of the composite film dropped to 0. The peak at 1713 cm-1 attributable to the stretching vibration of CO in infrared spectra significantly increased and the weight-average molecular weight (Mw) of the film decreased from 1.2 × 105 g mol-1 to 0.85 × 104 g mol-1. The melt flow rate was enhanced to 194.2 g/10 min. These results suggest that the present modified TiO2 could be utilized as a promising photocatalyst candidate for the degradation of plastics.

Interaction behaviors of sulfamethoxazole and microplastics in marine condition: Focusing on the synergistic effects of salinity and temperature

Microplastics and antibiotics are two common pollutants in the ocean. However, due to changes of salinity and temperature in the ocean, their interaction are significantly different from that of fresh water, and the mechanism remains unclear. Here, the interactions of sulfamethoxazole (SMZ) and microplastics were studied at different temperatures and salinities. The saturation adsorption capacity of SMZ in polypropylene (PP), polyethylene (PE), styrene (PS), polyvinyl chloride (PVC), and synthetic resins (ABS) were highest at the temperature of 20 °C, with 0.118 ± 0.002 mg·g−1, 0.106 ± 0.004 mg·g−1, 0.083 ± 0.002 mg·g−1, 0.062 ± 0.007 mg·g−1 and 0.056 ± 0.003 mg·g−1, respectively. The effect of temperature reduction is more significant than temperature rise. The intraparticle diffusion model is appropriate to PP, when film diffusion model suited for PS. The salinity has a more significant effect than temperature on different microplastics, due to the electrostatic adsorption and iron exchange. With the increase in salinity from 0.05% to 3.5%, the adsorption capacity of microplastics on SMZ fell by 53.3 ± 5%, and there was no discernible difference of various microplastics. The hydrogen bond and π-π conjugation of microplastics play an important role in the adsorption of SMZ. These findings further deepen the understanding of the interaction between microplastics and antibiotics in the marine environment.

Investigation of the impact of additive manufacturing techniques on the acoustic performance of a coiled-up resonator

Acoustic metamaterials (AMMs) offer innovative solutions for physics and engineering problems, allowing lighter, multiphysics, and sustainable systems. They are usually studied analytically or numerically and then tested on prototypes. For this reason, additive manufacturing (AM) techniques are a popular way of quickly realising AMMs' innovative geometrical designs. However, AM parameters are often standardised without considering the specific issues of each AMM geometrical shape, leading to a possible mismatch between the analytical (or numerical) and experimental results. In this study, a simple AMM-a coiled-up resonator-has been produced with different AM technologies [fused deposition modeling (FDM), stereolithography (SLA), and selective laser melting and materials (polylactic acid, polyethylene terephthalate glycol, resin, flexible resin, and stainless steel). The sound absorption performance of these samples has been measured in two research labs in Italy and compared with the analytical and numerical calculations. This permitted the identification of the best combinations of AM technologies, their setup, and materials matching the expected results. The SLA/resin combination performed better overall; however, cheaper and more easily manageable samples made with FDM and polyethylene terephthalate glycol can achieve the same acoustic performance through the optimal AM printing setup. It is expected that this methodology could also be replicated for other AMMs.

Effect of type of polymerization catalyst system on the degradation and stabilization of polyethylenes in the melt state—Part 4: Comparative antioxidant effectiveness on organoleptic extractables

AbstractSeveral polyethylene resins using Ziegler, metallocene, and Phillips catalyst technologies were examined to obtain more detailed information about the effect of different polymerization catalyst systems on the production of extractable thermo‐oxidative degradation products formed during melt processing cycles. This produces volatile organoleptic components (VOCs and extractable) such as hydrocarbons, alcohols, aldehydes, ketones, and carboxylic acids. Although some of the oxidation products are in‐chain bound, many are produced as free, easily extractable entities or volatile components. The purpose of this study is to identify the nature of the products by gas chromatography–mass spectrometry (GC–MS) and FTIR analysis. The identity of the VOCs formed is necessary to modify the product's quality or establish which are toxic and/or leachable with food products. The results show that the evolution of carbonyl products, nature, and quantity is influenced significantly by the polymer type and catalyst used. Over 300 organoleptics low molar mass degradation products, such as alkane, alkene, carbonyl, and alcohol functionalities were detected by GC–MS analysis coupled with FTIR analysis on hexane extractables. Certain stabilizers can control the generation of certain functionalities and inhibit others. Of importance was the discovery of the relationship between additive activity and structure and inhibition of the formation of specific types of oxidation functionalities to a particular catalyst system.

Life Cycle Assessment of Plastic Resin: A Case Study of the Petrochemical Industry in Thailand for the Production of HDPE Resin

Life cycle sustainability is an important tool for assessing product performance based on the three pillars of environment, economy and society. This study examined the life cycle impact, cost and social implications of high-density polyethylene (HDPE) resin. Environmental assessment revealed nonrenewable energy as the greatest impact followed by carcinogens, respiratory inorganics and global warming while economically, the operational cost of HDPE resin production was significantly highest. The social impact assessment following the United Nation Environmental Programme (UNEP)/ Society of Environmental Toxicology and Chemistry (SETAC) guidelines demonstrated optimal performance for all indicators except for gender ratio and disabled employee criteria which were lower human rights indicators than other companies. The subcategory of occupational health and safety should be specified in future aspects, such as rate of disease from company operation. Energy efficiency and material acquisition should be improved to reduce the environmental impact and positively redress declining costs, leading to decrease in disease rate among workers in the local community. Results suggested that improving environmental impact would increase economic performance through optimal energy efficiency, while the social life cycle assessment indicator should mainly focus on health and safety in the event of disease arising from business operations.

Is the petrochemical industry an overlooked critical source of environmental microplastics?

Microplastics (MPs) are ubiquitous in the environment and have been verified to be harmful to organisms. The petrochemical industry is a possible contributor, for it is the primary plastic producer but is not focused on. In this background, MPs in the influent, effluent, activated sludge, and expatriate sludge of a typical petrochemical wastewater treatment plant (PWWTP) were identified by the laser infrared imaging spectrometer (LDIR). It revealed that the abundances of MPs in the influent and effluent were as high as 10310 and 1280 items/L with a removal efficiency of 87.6%. The removed MPs accumulated in the sludge, and the MP abundances in activated and expatriate sludge reached 4328 and 10767 items/g, respectively. It is estimated that 1440,000 billion MPs might be released into the environment by the petrochemical industry in 2021 globally. For the specific PWWTP, 25 types of MPs were identified, among which Polypropylene (PP), Polyethylene (PE), and Silicone resin were dominant. All of the detected MPs were smaller than 350 µm, and those smaller than 100 µm prevailed. As for the shape, the fragment was dominant. The study confirmed the critical status of the petrochemical industry in releasing MPs for the first time.

Synthesis of silylamine and siloxyamine compounds: A novel approach to flame retardancy of polypropylene and Epoxy resins

A series of innovative flame retardants containing N-Si and N-O-Si bonds have been synthesized. Their chemical structures were verified by nuclear magnetic resonance (NMR) spectroscopy and thermal stabilities determined by thermogravimetric analysis (TGA). The results indicate that their thermal and hydrolytic stabilities could be adjusted by fine tuning their silylamine (N-Si) and siloxyamine (N-O-Si) skeletons. Thus, the substituents bonded to the phthalimides, such as diphenylmethylsilyl, dimethylphenylsilyl, diphenyl‑tert-butylsilyl, triisopropylsilyl or diphenylmethylsiloxy; whichever was attached to the imide played a significant role on its thermal and hydrolytic properties. Upon thermal dissociation, the N-Si and N-O-Si compounds were shown to yield aminyl, silyl and oxygen-centered radicals that provided fire proofing effect in polypropylene (PP) films alone and a synergistic effect in combination with conventional phosphorous flame retardant in PP, linear low-density polyethylene (LLDPE) and epoxy resins (EP). Their efficacy as flame retardants alone in thin PP films were evaluated according to the DIN4102-B2 test. Both N-Si and N-O-Si significantly slowed down the burning of PP films. Moreover, their potential as adjuvants with a conventional phosphorous based flame retardant, i.e., spirocyclic phosphonate (AFLAMMIT® PCO 900) in PP and EP resins was evaluated according to the UL-94 V fire standard. A synergistic effect was observed when the phosphorous flame retardant was combined with either N-Si or N-O-SI containing compounds, since none of the flame retardants by themselves could provide V-0 rating in the UL94-V test in PP, LLDPE or EP resins even at much higher loadings. The thermogravimetric analysis carried out under inert atmosphere revealed enhanced and earlier onset of decomposition and thermal activation of phosphorous based flame retardant in the presence of N-Si or N-O-Si in comparison to spirocyclic phosphonate, N-Si or N-O-Si used alone, respectively. The interaction of the phosphorus flame retardant with N-Si was verified by 31P NMR.

The influence of thermo-hygrometric conditions on metamaterials' acoustic performance: an investigation on a 3D printed coiled-up resonator

In the last decades, coiled-up resonators have become popular within the metamaterial research community for narrow band, low frequency resonances combined to subwavelength thickness. Such structures are particularly suited to one of the most widespread manufacturing processes, i.e. PET-based 3D printing. Acoustic performance of coiled-up resonators depends on the geometrical parameters' variation, which is influenced by thermo-hygrometric conditions; however, the deformation itself needs to be further investigated. For this reason, the present paper evaluates the correlation between temperature, relative humidity, and the geometrical parameters' (spiral length and hole diameter) deformations and, consequently, the acoustic performance of a 3D printed coiled-up resonator. A combined approach through analytical, numerical, and experimental measurements quantified the frequency shift of the resonance peaks (within 300 Hz - 5000 Hz) in terms of sound absorption coefficient increasing the temperature (T=10-50° C), and the relative humidity (RH=20-80 %) of the samples. Relative humidity variations turned neglectable discrepancies on sound absorption's peaks. On the other hand, the increase in temperature caused a frequency peaks' shift following an exponential trend: this behavior is straight related to the exponential relationship between the temperature and specific volume function of polyethylene resins.

Replacement of Missing Anterior with Maryland Bridge using Ribbond: A Case Report

Replacement of missing mandibular central incisor is difficult challenge in esthetic dentistry. Resin bonded bridges or maryland bridges can be considered as a treatment of choice in such conditions, which restore the oral function and esthetic of the patient. Maryland bridge preparation requires minimal preparation of the tooth and the bridge can be attached to the periodontally sound adjacent teeth.The combined use of polyethylene fibre and resin composite help achieve durable and functional result.This case report describes the case of esthetic restoration of a young women with midline spacing of mandibular anterior teeth.

A rheology and processing study on controlling material and process defects in polymer melt extrusion film casting using polymer blends

The primary objective of this research paper is to control the material and process defects in polymer melt extrusion film casting (EFC) process for linear chain architecture polyethylene (PE) resins through polymer blending methodology. Extrusion film casting is a well-known industrially important manufacturing process that is used to manufacture thousands of tons of polymer/plastic films/sheets and coated products. In this research, the necking defect in an EFC process has been studied experimentally for a linear low density polyethylene (LLDPE) resin and attempts have been made to control its necking by blending in a long chain branched (LCB) low density polyethylene (LDPE) resin. The blending methodology is based on the understanding that a LDPE resin displays enhanced resistance to necking as compared to the LLDPE resin. It is found that added LDPE resin enhances necking resistance for the primary LLDPE resin. Further, as the LDPE concentration increases in the blend formulation, the necking is further reduced as compared to pure LLDPE. Analogous to past studies on EFC of linear and long chain branched architecture containing PEs, it is observed that as the LDPE is increased in the blend formulations, the formulations displayed enhanced melt elasticity and extensional strain hardening in rheological studies. It is concluded from this study that polyethylene resins having linear chain architecture can be made amenable to enhanced resistance to necking using appropriate amount of a long chain branched resins. Finally, process defects such as the draw resonance onset could be shifted to higher draw ratios as the LDPE level is increased in the LLDPE-LDPE blend formulation.

Overview of Polyethylene Based Multi-layered Geomembrane Through Blown Extrusion Process

Geomembranes are low-permeable liners used to control the molecular migration in many proven applications. Landfills is most common application in the field of civil and environmental engineering. Geomembrane is the main component in lining system which works as hydraulic barrier. The polyolefins are the basic materials of liner and more commonly polypropylene and polyethylene are preferred. Commercial manufacturing process involves extrusion techniques viz cast extrusion and blown extrusion process. The individual process is designed for multiple layered structures which are then coextruded to lead into a single liner. Typical structure comprises, high to low-density polyethylene (PE) resin, processing aids, stabilisers to retard the degradation through ultra-violet rays, photo-oxidation, and thermal oxidation. The stabilizer is usually used in smaller dosses to avoid degradations which includes, 2 to 3% carbon-black (CB), 0.5 to 1% antioxidants (AO), and plasticizing additives to introduce the flexibility. During the process, components are homogenised in specially designed screws of feeding and mixing zones. The formulated melt is co-extruded through specially designed die of multi-layered structures. The subsequent melt enters in circular die with a certain pressure which leads to bubbled shaped films. The variation in the surface morphology layer structure and layer number are the important technical aspects to alter the required end application. Finally, manufactured geomembrane is qualified as per the international specifications which are governed by geosynthetic research institute (GSI/GRI).

Microplastics pollution in the river Karnaphuli: a preliminary study on a tidal confluence river in the southeast coast of Bangladesh.

Bangladesh is a deltaic country in Asia, and its riverine systems ultimately drain into the Bay of Bengal. Plastic is a severe environmental issue for coastal-marine ecosystems due to the indiscriminate usage and discarding of plastic items in the upstream river that eventually find their route into the Bay of Bengal. Microplastics (MPs)are widespread pollutants in almost all environmental compartments, including aquatic environments. This study aimed to quantify and understand the distribution of microplastics in surface water and sediments of the river Karnaphuli, a tidal confluence river adjacent to the Chattogram seaport city of Bangladesh, a highly inhabited and industrial area on the southeast coast of the Bay of Bengal. A manta trawl net (300-µm mesh size) was used to collect surface water samples, while an Ekman dredge was used to collect sediment samples. The concentrations of microplastics in the surface water of the river Karnaphuli during late monsoon, winter, and early summer were recorded to be 120,111.11, 152,222.22, and 164,444.44 items/km2, respectively, while in sediments, those were recorded to be 103.83, 137.50, and 103.67 items/kg, respectively. A higher abundance of microplastics was observed in downstream surface water (228,888.88 items/km2) and sediments (164.17 items/kg). Smaller sizes (0.3 to 0.5mm) of microplastics were predominant, fibers or threads were the frequent types, and black was the most common color in the river Karnaphuli. The Fourier transform infrared analysis revealed that polyethylene terephthalate (surface water: 22%, sediments: 19%), polyamide (surface water: 15%, sediments: 13%), polyethylene (surface water: 12%, sediments: 18%), polystyrene (surface water: 13%, sediments: 11%), and alkyd resin (surface water: 13%, sediments: 10%) were the most prevalent polymers in the river Karnaphuli. Moreover, there was a moderate positive correlation between MPs abundance in surface water and sediments. Therefore, improved long-term research (in different seasons with horizontal and vertical monitoring) is necessary in order to accurately determine the flux of microplastics from the river Karnaphuli to the Bay of Bengal.

Influence of poly(ionic) liquid incorporation within resin wafer electrodeionization for reduced energy consumption in brackish water desalination

Resin Wafer Electrodeionization (RW-EDI) is recognized as a promising technology for energy-efficient desalination of brackish water. However, RW-EDI is limited by energy requirements for the treatment of high-salinity feeds which prevent the large-scale deployment of this technology. Several material factors influence the resulting performance of RW-EDI. Current state-of-the-art wafers rely on a nonconductive polymer binder to ensure mechanical stability of resin wafers. However, a robust ionic polymer could improve resin wafer conductivity and energy efficiency of RW-EDI systems. Herein, this research studied the influence of ionic polymers within RW-EDI resin wafers. Specifically, polymer ionic liquid-based (PIL) ionic polymers were incorporated within ion exchange resin wafer formulations to enhance ion conductivity during RW-EDI operation. Two different resin wafer formulations were developed incorporating phosphonium-based PILs. These new resin wafer formulations were tested in a benchtop RW-EDI system at varied applied voltages. The results demonstrated that PIL loading had a major influence on the mechanical stability and conductive properties of the resin wafer as well as the RW-EDI performance. Resin wafers incorporating PILs exhibited an order of magnitude increase in ion conductivity (2.21 × 10-2 mS/cm) as compared to conventional polyethylene resin wafers (8.64 × 10-3 mS/cm). In the RW-EDI system, a 9.3 % decrease in specific energy consumption was achieved when PIL with 2.5 g loading of phosphonium-based PIL was employed, as compared to conventional polyethylene-based resin wafers. The results indicate that PIL ionic polymers can significantly improve energy efficiency within RW-EDI systems. The results also suggest that future studies should investigate additional ionic polymer materials for additional energy efficiency improvements within RW-EDI systems.

Avient's NIR sortable dark colorants recognized by APR

On November 17, 2022, Avient Corporation announced that its line of near-infrared (NIR) sortable dark colorants was recently recognized by the Association of Plastics Recyclers (APR) under its Meets Preferred Guidance (MPG) program. With the recognition, OnColor™ NIR Sortable Colorants are preferred for high-density polyethylene (HDPE) resin in black and dark colors, according to the APR Design® Guide for Plastics Recyclability. In addition, testing is underway to support an application for MPG recognition for the same colorants for polypropylene resin (PP).

A maddock mixer design that mitigates gels in polyethylene resin film applications

Maddock mixers are ubiquitous in plastics processing for single-screw extruders and injection molding plasticators due to their low cost to build and their ability to provide a uniform level of dispersive mixing. If the mixer is designed properly, all entering solid polymer fragments and certain types of gels can be trapped and dispersed into the matrix resin. Many mixers that are used commercially, however, provide lower levels of dispersive stress mixing than required by the process and they can degrade polyethylene (PE) resins. This paper will describe the mechanisms that are occurring in a Maddock mixer and develop guidelines for obtaining optimal mixing stresses while mitigating resin degradation.

Comparison of permeabilities of eight different types of cytotoxic drugs to five gloves with different materials by LC-MS/MS methods to reduce occupational exposure of medical personnel.

Occupational exposure is a long-standing public health concern, which has drawn more and more attention in recent years to the problem of how to carry out occupational protection effectively. Gloves are regarded as the most critical protective equipment for cytotoxic medications. However, there is still little research conducted on the protective performance of gloves made of different materials and the optimal glove combination for cytotoxic agents. In this research, a specific instrument intended for glove permeation experiment was designed, with various methods of liquid chromatography-tandem mass spectrometry (LC-MS/MS) developed and validated. By using the specific instrument and LC-MS/MS methods, a study was conducted on the permeation ability of eight selected cytotoxic drugs (fluorouracil, epirubicin (EPI), docetaxel (DCT), methotrexate (MTX), cyclophosphamide (CTX), etoposide (ETP), vincristine sulfate (VCR), and cisplatin derivatives Pt-(DDTC)3) into five kinds of gloves (rubber (RB), nitrile (NT), chlorinated polyethylene (CPE), low-density polyethylene, and polyvinylchloride (PVC) resin) given different contact times. Then, the experimental data were analyzed through a generalized estimation equation and Pearson correlation analysis. The results show that within a short period of time (less than five minutes), ETP, CTX, fluorouracil, DCT, and cisplatin passed through five types of gloves but the level of MTX, VCR, and EPI permeation was minimal, despite the duration of contact between the three drugs and the gloves reaching as long as three hours. Furthermore, the permeation of DCT and ETP was found to be positively correlated with time. Chlorinated polyethylene and PVC resin perform well in protecting against most cytotoxic drugs and are recommendable for clinical practice. Due to the poor protective ability, RB gloves are not recommended for this purpose. Based on the performance of various gloves in offering protection, the protection grade of two gloves can be deduced. Chlorinated polyethylene + PVC resin, CPE + NT glove combination shows good protective performance against most target drugs and can be recommended for clinical practice.