Photocatalytic technology has shown excellent application potential in water pollution treatment, but the design and preparation of reusable photocatalysts that can degrade multiple pollutants with high efficiency is a major difficulty limiting the development of this field. Herein, the CF/WO3-x/BiOBr heterojunctions with hierarchical structures were synthesized via a two-step hydrothermal method, in which sheet BiOBr with high-efficiency {001} exposed crystal plane self-assembled into flower-like structure. Due to the unique microstructure control and suitable energy band structure matching, the CF/WO3-x/BiOBr-2.5 M has shown excellent photodegradation effect on a variety of pollutants at the same time (91.2 % for RhB dye, 71.5 % for TCH antibiotic and 88.2 % for Cr(VI) heavy metal pollutant). The synthesis of WO3-x/BiOBr heterojunctions enabled an efficient redox reaction, which facilitated the effective separation and transport of electron-hole pairs. Overall, the results provide a novel approach to designing cloth-based photocatalytic systems with unique structures capable of degrading multiple pollutants.