The external insulation strength of the power equipment sleeve in the substation and converter station will be reduced with the increase in altitude and atmosphere pollution. The weakness of external insulation seriously threatens the safe operation of electrical equipment. At present, there are few studies and conclusions that focus on the flashover characteristics of power equipment bushing in high-altitude polluted areas. Therefore, this paper takes the 220 kV voltage level bushing as the research object and studies the Alternating Current (AC) pollution flashover characteristics and lightning and switching impulse flashover characteristics at low pressure. The insulation configuration at high-altitude polluted areas is analyzed. Finally, the insulation configuration scheme, which is suitable for high-altitude polluted areas, is proposed. The results show that the AC pollution flashover voltages of the bushing decrease with the decrease in the atmospheric pressure and the increase in the salt density as a power exponent function. The impulse flashover voltages also decrease with the decrease in the atmospheric pressure as a power exponent function. The atmospheric pressure/pollution impact characteristic index is related to the type of voltage, the value of the atmospheric pressure, and the value of the salt density. The test bushing does not meet the insulation configuration requirements in some high-altitude polluted areas. Through the analysis and calculation of the test results, the bushing insulation configuration scheme in high-altitude polluted areas is proposed. The research results can provide a reference for the external insulation design of bushings in substations and converter stations in high-altitude polluted areas.