The plywood processing industry is one of the fastest growing industries. However, this has a negative impact and may cause the emergence of air pollution by dust produced from the plywood processing industry. Air pollution caused by the plywood processing industry can trigger problems such as the atmosphere, the economy, and health. The plywood processing industry has potential to create a source of pollution in the form of dust which is harmful to the environment and the health of workers. This study aimed to determine and analyze the assosiation between PM2,5 wood dust exposure and the case of acute respiratory infection (ARI) in plywood industry workers. The research method used is cross-sectional with a total sample of 142 female workers at 17 locations PM2,5 wood dust measurement and using a standardized Questionnaire British Medical Research Council (QUES BMRC -86). PM2,5 wood dust measurement using tools DustTrak. Based on the results of the study showed that the average of PM2,5 at 17 points of 5.23 mg/m3 which exceeds the Threshold Value according to the Regulation of the Minister of Manpower of the Republic of Indonesia Number 5 of 2018 concerning the Threshold Value of Chemical Factors in the Air of the Work Environment for Types of Softwood Dust, namely 5 mg/m3 who are at risk of experiencing the case of acute respiratory infection. The results of the analysis and the results of the logistic regression test show that there are 4 significant variables is a assosiation between with the case of acute respiratory infection, for exposure to PM2,5 dust (p = <0.001; RP = 12,757; 95% CI = 1,819 - 89,477), working period (p value = <0.001; RP = 13.048; 95% CI = 4.217 – 40.377), use of personal protective equipment (p value = <0.001; IDR 7,568; 95% CI = 2.453 – 23.352), and age (p value = <0.001, RP = 5.582, 95% CI = 2.323 – 13.413). The conclusion of this study is that there is a assosiation between exposure to PM2,5, wood dust, years of service, use of personal protective equipment, age and the case of acute respiratory infection in plywood industry workers. Therefore, to prevent the occurrence of acute respiratory infection, workers are advised to use complete personal protective equipment when doing work in the plywood industry of PT. Muara Kayu Sengon, Jatilawang District, Banyumas Regency.