The global changes in the 21st century regarding human populations speak of the changed position regarding the nation-state and the attempts of its institutions to control social, economic, and political life, as it has been done for centuries. In itself, this is a symptom of serious changes in the relationship between man and the world. The process of globalization, related to the crisis that the nation-state is going through, does not necessarily mean a finding of its decline. Rather, it expresses the fact that in the state of globality, the nation-state finds itself in a completely changed environment to which it must find ways to adapt to be able to define itself anew. The process of cosmopolitanism can be accepted as one of the options for this self-determination. Regionalism as a socio-structural phenomenon is limited at certain times by the social space and the individuals in it. Rationalism is a form of glocalization, while cosmopolitanism allows for this mobility, both of and in the social, and for the formation of a specific, cosmopolitan worldview on the part of the individual. Today, we as "mobile people" are characterized not only by our technological mobility (owning and carrying with us various technological gadgets) but also by our extremely flexible and (if we wish) full awareness of what is happening around us. us. Another question is, however, whether the setting of internal limitations by the person himself in front of himself, and of what he will undertake as an action, will be realized as an intention or will have the strength to set before himself as a goal to overcome and extinguishes the risky situations that await him in the future. Even if cosmopolitan in spirit, individual human subjectivity will always be the bearer of concrete facts such as origin, bioanthropological characteristics, value, and moral specifics, but they are not the leading ones. The individual specifics are the individual nuances in the rich originality that represents the cosmopolitan personality. Cosmopolitanism as the current and future social trajectory of humanity must be and lead to the absence of antagonistic, separating boundaries that are embedded in our human nature.