BackgroundIn the current college environment, students’ mood disorders have become an increasingly important problem, affecting students’ learning efficiency and the overall school environment. Therefore, managing ideological and political education in colleges and universities can coordinate treating and improving students’ emotional disorders.Subjects and MethodsA randomized controlled trial was used to select 100 students with mood disorders in a university and divide them into two groups. The intervention group implemented the synergistic development strategy of ideological and political education and management, while the control group maintained the original teaching and administration. The collaborative development strategy mainly includes strengthening the effectiveness of ideological and political courses, increasing the participation of students, and improving the management system. During the study period, the self-rating Scale of mood disorders and the questionnaire on learning satisfaction were used to regularly evaluate the two groups of students. The analysis software is SPSS23.0.ResultsThe average MDQ score decreased by 35% in the intervention group, while the average MDQ score decreased by only 10% in the control group. Learning satisfaction increased by 25% in the intervention group, while there was no significant change in learning joy in the control group.ConclusionsThe synergistic development of ideological and political education and management in colleges and universities can alleviate students’ mood disorders and improve their learning satisfaction. This provides a practical way for colleges and universities to strengthen students’ mental state and learning efficiency.AcknowledgementThe Second Batch of Teaching Reform Projects in the 13th Five-Year Plan of Zhejiang Province’ Higher Education (Grant No.jg20190965).