Objective: Analyze Ghana's vaccine regulations framework to identify strengths, limitations and policy refinement opportunities regarding manufacturing/distribution. Method: Structured CRuPAC legal review model encompassing comparative assessment of Food/Drugs Act and Public Health Act provisions based on identified criteria; investigation of rules, historical applications and guiding principles; counterargument evaluation; advice formulation integrates relevant case laws, specific legislation sections and academic literature. Results: Robust ecosystem found but with bureaucracy/access constraints; precedent supports compulsory vaccination upholding safety/welfare principles. Conclusions & Recommendations: Balance safety considerations and industrial growth incentives; expedite registration pathways for proven developers, offer tax incentives for local producers, leverage compulsory licensing during shortages; increase healthcare budgets for system strengthening. Contributions: Granular legal analysis establishes evaluative baseline; structured CRuPAC assessment elucidates reform gaps; expansive literature review provides contextualization; reasoned interpretation of vague provisions based on legal theory; tailored, evidence-based recommendations. Significance: Highlights precedents, incentives and measures to optimize policies for regulators/manufacturers/legislatures regarding emergency preparedness.