Event Abstract Back to Event Quantitative imaging of magnetic nanoparticle distributions in organs by a combined multipole-multiple dipoles approach Frank Wiekhorst1*, Daniel Baumgarten2, Wolfgang Haberkorn1, Uwe Steinhoff1, Jens Hauseisen3, Markus Baer1 and Lutz Trahms1 1 Physikalisch-Technische Bundesanstalt, Germany 2 Ilmenau University of Technology, Germany 3 University Hospital, Germany The accurate knowledge of magnetic nanoparticle distributions in biological tissue is an essential prerequisite for the development of novel magnetic nanoparticle based therapeutical applications such as drug targeting and hyperthermia. Measurement techniques like magnetorelaxometry, dc- and ac-susceptometry or remanence so far allow a sensitive as well as robust quantification and localization of focussed (point-like) nanoparticle accumulations in tissue or to reconstruct quantitatively the nanoparticle distibution from individual measurements of a dissected organ. For non-destructive reconstruction an ill-posed inverse problem has to be solved to get underlying nanoparticle distribution from a measured magnetic field pattern. Here, we present a combined approach for the quantitative reconstruction of spatially extended nanoparticle distributions. Within the framework of minimum norm estimates solving the inverse problem we use a multipole expansion to localize the centre and to quantify the total amount of the nanoparticle distribution. Additionally, the principal dimensions of the source distribution are estimated by a second multipole expansion using the afore determined distribution centre as expansion point. Finally, the quantitative distribution is reconstructed modelling the magnetic nanoparticle accumulation by magnetic point dipoles on a planar grid centred at the multipole expansion point. We illustrate this procedure by a simulation of our typical measurement setting comprising extended sources with dimensions up to 20 cm. We find a localization uncertainty below one centimetre. The total magnetic moment can be estimated with an uncertainty of less than 5%. Quantitative images obtained from simulated data as well as from measurement data demonstrate feasibility and performance of our approach. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Nanoparticles, Biosusceptometry and Effects of Magnetic Fields Citation: Wiekhorst F, Baumgarten D, Haberkorn W, Steinhoff U, Hauseisen J, Baer M and Trahms L (2010). Quantitative imaging of magnetic nanoparticle distributions in organs by a combined multipole-multiple dipoles approach. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00388 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 08 Apr 2010; Published Online: 08 Apr 2010. * Correspondence: Frank Wiekhorst, Physikalisch-Technische Bundesanstalt, Berlin, Germany, frank.wiekhorst@ptb.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Frank Wiekhorst Daniel Baumgarten Wolfgang Haberkorn Uwe Steinhoff Jens Hauseisen Markus Baer Lutz Trahms Google Frank Wiekhorst Daniel Baumgarten Wolfgang Haberkorn Uwe Steinhoff Jens Hauseisen Markus Baer Lutz Trahms Google Scholar Frank Wiekhorst Daniel Baumgarten Wolfgang Haberkorn Uwe Steinhoff Jens Hauseisen Markus Baer Lutz Trahms PubMed Frank Wiekhorst Daniel Baumgarten Wolfgang Haberkorn Uwe Steinhoff Jens Hauseisen Markus Baer Lutz Trahms Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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