Pneumococcic Meningitis Research Articles

Treatment of pneumococcic meningitis by systemic penicillin

Treatment of pneumococcic meningitis by systemic penicillin

TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH SULFADIAZINE AND INTRATHECAL PENICILLIN G WITH RECOVERY

Case Reports1 March 1948TREATMENT OF PNEUMOCOCCAL MENINGITIS WITH SULFADIAZINE AND INTRATHECAL PENICILLIN G WITH RECOVERYGARFIELD S. BARNET, M.D.GARFIELD S. BARNET, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-3-642 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to the advent of chemotherapy, pneumococcal meningitis carried mortality of almost 100 per cent.1, 7 Sulfonamides lowered this depressing figure to some extent.3 Recent minimum mortality figures representing the results of combined sulfonamide and penicillin therapy approximate 40 per cent.4The present case report was deemed worthwhile because of the following features:(1) The progression of meningitis during the administration of intramuscular and intravenous penicillin.(2) The exclusive use of crystalline penicillin G for intrathecal administration in concentrated solution without adverse reaction.CASE REPORTA 23 year old married colored laborer noted the onset of headache, fever, vomiting, and...Bibliography1. SIEGAL S: Transverse myelopathy following recovery from pneumococcic meningitis, Jr. Am. Med. Assoc., 1945, cxxix, 547-550. CrossrefGoogle Scholar2. JEPSONWHITTY RPCW: Treatment of pneumococcic meningitis, Lancet, 1946, i, 228-232. CrossrefGoogle Scholar3. BRAINERDBRADLEY HE: Treatment of bacterial meningitis with penicillin, sulfonamides, and sera, Calif. Med., 1947, lxvi, 57-61. Google Scholar4. ROMANSKY MJ: The current status of penicillin therapy, Vet. Admin. Tech. Bull., 10-25, 1947, 1-13. Google Scholar5. PRICEHODGES AHJH: The treatment of meningitis with penicillin injected intravenously and intramuscularly, New York State Med. Jr., 1944, xliv, 2012-2014. Google Scholar6. SMITHDUTHIECAIRNS HVESH: Chemotherapy of pneumococcal meningitis, Lancet, 1946, i, 185-193. CrossrefGoogle Scholar7. APPELBAUMNELSON EJ: Penicillin in the treatment of pneumococcic meningitis, Jr. Am. Med. Assoc., 1945, cxxviii, 778-781. CrossrefGoogle Scholar8. COOKEGOLDRING JVD: The concentration of penicillin in various body fluids during penicillin therapy, Jr. Am. Med. Assoc., 1945, cxxvii, 80-87. CrossrefGoogle Scholar9. SWEETDUMOFFDOWLINGLEPPER LKSEHFMH: The treatment of pneumococcic meningitis with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 263-267. CrossrefGoogle Scholar10. JOHNSONWALKER HCEH: Intraventricular penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 217-219. CrossrefGoogle Scholar11. SWEENEYLESLIE JSJT: Pneumococcic meningitis successfully treated with penicillin and sulfadiazine, Ann. Int. Med., 1946, xxiv, 705-707. Google Scholar12. ROTMAN-KAVKAHIRSHDOWLING GHLHF: A comparative study of penicillins X and G and crystalline penicillin G, New Eng. Jr. Med., 1947, ccxxxvi, 314-318. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Aspinwall, Pennsylvania*Received for publication August 15, 1947.Published with permission of the Chief Medical Director, Department of Medicine and Surgery, Veterans Administration, who assumes no responsibility for the opinions expressed or conclusions drawn by the author.†Resident, Internal Medicine. The resident training program at the Veterans Administration Hospital, Aspinwall, Pa., is under the supervision of the Dean's Committee, School of Medicine, University of Pittsburgh. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIntra-cerebrospinal fluid antibiotics to treat central nervous system infections: A review and update 1 March 1948Volume 28, Issue 3Page: 642-647KeywordsChemotherapyFeversHeadachesHospital medicineMeningitisMortalityPenicillinSulfonamideSurgeryVomiting Issue Published: 1 March 1948 PDF downloadLoading ...

PNEUMOCOCCIC MENINGITIS

IN THE era preceding introduction of the sulfonamide drugs the mortality rate of pneumococcic meningitis was almost 100 per cent. 1 With the advent of these antibacterial drugs, numerous cases of recovery from this type of meningitis have been reported. Thus, with the use of the sulfonamide drugs, the mortality rate had dropped to levels varying from 33 2 to 66 per cent. 3 Recently, even more favorable results have been reported in the treatment of pneumococcic meningitis with the combined administration of penicillin and sulfadiazine. Waring and Smith 4 observed only 1 death among 13 patients; Hutchins and Davies 5 reported 4 deaths among 14 children, and Smith, Duthie and Cairns 6 had 9 deaths among 38 patients treated with sulfadiazine and penicillin. In spite of the sharp drop in the mortality rate following the advent of chemotherapy, the occurrence of this disease in infants under 3 months of

PERIPHERAL NEURITIS AS A COMPLICATION OF PENICILLIN THERAPY

Peripheral neuritis as a complication of penicillin therapy has not heretofore been reported. The present communication is concerned with the observation of localized peripheral neuritis in 7 patients receiving intramuscular injections of penicillin therapeutically. There are a few reports in the literature which indicate that penicillin may have a toxic effect on nervous tissue. Johnson and Walker¹reported the development of convulsions in a patient following the intraventricular administration of penicillin. Convulsions were induced subsequently in animals by the direct application of penicillin to the cerebral cortex.²Russell and Beck³have described hemorrhage and cortical degeneration subsequent to the application of penicillin to the brain of a rabbit. Of great importance is the report of Sweet and his associates,⁴who described the neurologic complications indicative of a myeloradiculitis occurring in 4 patients after the intrathecal administration of penicillin for pneumococcic meningitis. The neurologic symptoms in these

PNEUMOCOCCIC MENINGITIS SUCCESSFULLY TREATED WITH PENICILLIN AND SULFADIAZINE

Case Reports1 April 1946PNEUMOCOCCIC MENINGITIS SUCCESSFULLY TREATED WITH PENICILLIN AND SULFADIAZINEJAMES S. SWEENEY, JOHN T. LESLIEJAMES S. SWEENEYSearch for more papers by this author, JOHN T. LESLIESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-24-4-705 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe prognosis in cases of pneumococcic meningitis has improved considerably since the advent of the sulfonamides and still more so since penicillin.1, 2, 3, 4, 5, 6, 7, 8 The mortality rate, however, continues to be quite high. Very few individual cases or series of cases treated with penicillin or penicillin and sulfa drugs have been reported. It is anticipated that as more cases are reported and thus more experience gained, further improvement in methods of treatment will follow and in turn a material reduction will result in both mortality and morbidity.CASE REPORTA 22 year old white soldier...Bibliography1. SWEETDUMOFF-STANLEYDOWLINGLEPPER LKEHFMH: The treatment of pneumococcic meningitis with penicillin, Jr. Am. Med. Assoc., 1945, cclxiii, 263-267. CrossrefGoogle Scholar2. LITVOKAPPELBAUMGREENE AMEM: Pneumococcic meningitis, Am. Jr. Dis. Child., 1944, lxvii, 485-486. CrossrefGoogle Scholar3. HARFORDMARTINHAGEMANWOOD CGSPPOWB: Treatment of staphylococcic, pneumococcic, gonococcic and other infections with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 325-329. CrossrefGoogle Scholar4. DAWSONHOBBY MHGL: The clinical use of penicillin, Jr. Am. Med. Assoc., 1944, cxxiv, 611-622. CrossrefGoogle Scholar5. EVANS AL: The treatment of intracranial infections with penicillin, Jr. Am. Med. Assoc., 1944, cxxiv, 641-643. CrossrefGoogle Scholar6. WARINGSMITH AJMH: Combined penicillin and sulfonamide therapy in the treatment of pneumococcic meningitis, Jr. Am. Med. Assoc., 1944, cxxvi, 418-424. CrossrefGoogle Scholar7. ROSENBERGARLING DHPA: Penicillin in the treatment of meningitis, Jr. Am. Med. Assoc., 1944, cxxv, 1011-1017. CrossrefGoogle Scholar8. CAIRNSDUTHIELEWINSMITH HESWSHV: Pneumococcal meningitis treated with penicillin, Lancet, 1944, i, 655. CrossrefGoogle Scholar9. RUEGSEGGER JM: Pneumococcal meningitis, Ann. Int. Med., 1942, xvii, 693-721. Google Scholar10. JOHNSONWALKER HCEA: Intraventricular penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 217-219. CrossrefGoogle Scholar11. COOKEGOLDRING JVD: The concentration of penicillin in various body fluids during penicillin therapy, Jr. Am. Med. Assoc., 1945, cxxvii, 80-87. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication April 9, 1945.From Bushnell General Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDie Infektionskrankheiten 1 April 1946Volume 24, Issue 4Page: 705-707KeywordsDeath ratesDrugsMeningitisMorbidityMortalityPenicillinSulfonamide Issue Published: 1 April 1946 PDF downloadLoading ...

TRANSVERSE MYELOPATHY FOLLOWING RECOVERY FROM PNEUMOCOCCIC MENINGITIS

Widespread use of penicillin has aroused interest in the management of acute bacterial meningitis. Perhaps the most fatal type has been pneumococcic meningitis, but recent reports have offered hope that at long last we possess a potent weapon against this disease. The case herein reported illustrates the occurrence of an unusual complication, transverse myelopathy, in the course of recovery from acute bacterial meningitis. This sequel is of particular current interest because of the recent report by Sweet and his co-workers 1 of severe though reversible spinal cord or nerve root damage following recovery from pneumococcic meningitis treated with penicillin intrathecally. REPORT OF CASE A woman aged 66, admitted to the hospital in a state of restless stupor, had awakened that morning at 8, according to her physician, complaining of pain in and behind her left ear. When he saw her one hour later he had to irrigate the external canal

RECURRENCES OF PNEUMOCOCCIC MENINGITIS

Craddock and Bowers 1 described a patient having repeated attacks of pneumococcic meningitis. The patient of Hopkins and his co-workers 2 had three acute episodes of sinusitis complicated each time by pneumococcic meningitis. Recovery followed sulfonamide medication and treatment of the sinusitis. The patient who is the subject of the present report has been under the care of Dr. E. W. Westland in the West Suburban Hospital. When first seen she was 7 years old and had always been well since an uncomplicated skull fracture two and one-half years before. Within four years she has been admitted to various hospitals for five acute attacks of pneumococcic meningitis. The organism isolated from the spinal fluid in three attacks has been type XXI. There is no known focus in the ears, respiratory tract or the accessory sinuses. X-ray examinations of the lung, skull and sinuses have been negative. In each recurrence the

Meningite pneumocócica: Tratamento pela penicilina associada a sulfapiridina

E' relatado um caso de meningite pneumocócica pós-otite e mastoidite, tratado com sucesso pela penicilina associada à sulfapiridina. Tanto o composto sulfonamídico como a penicilina isoladamente não tiveram efeito terapêutico satisfatório. A evolução da meningite é estudada por exames diários do liqüido cefalorraquidiano.

MENINGOCOCCIC MENINGITIS TREATED WITH SULFADIAZINE AND SULFAMERAZINE: A THREE YEAR STUDY

Article1 September 1945MENINGOCOCCIC MENINGITIS TREATED WITH SULFADIAZINE AND SULFAMERAZINE: A THREE YEAR STUDYLEWIS K. SWEET, M.D., EDITH DUMOFF-STANLEY, M.D., HARRY F. DOWLING, M.D., F.A.C.P.LEWIS K. SWEET, M.D.Search for more papers by this author, EDITH DUMOFF-STANLEY, M.D.Search for more papers by this author, HARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-23-3-338 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMeningococcic meningitis has been encountered with considerable frequency in the Gallinger Municipal Hospital as well as throughout the United States during the past few years. Previous reports from this clinic1, 2and from others3, 4, 5, 6have amply demonstrated the suitability of sulfadiazine and sulfamerazine for the treatment of this type of infection. The number of patients reported in each of these studies has been relatively small, however, or the period of time covered by them has been short. It still is pertinent to question the efficacy of these drugs when used in large numbers of patients treated over...Bibliography1. FELDMANSWEETDOWLING HALKHF: Sulfadiazine therapy of purulent meningitis, including its use in twenty-four consecutive patients with meningococcic meningitis, War Med., 1942, ii, 995-1007. Google Scholar2. LEPPERSWEETDOWLING MHLKHF: The treatment of meningococcic infections with sulfadiazine and sulfamerazine (sulfamethyldiazine, monomethylsulfadiazine), Jr. Am. Med. Assoc., 1943, cxxiii, 134-138. CrossrefGoogle Scholar3. DINGLETHOMASMORTON JHLAR: Treatment of meningococcic meningitis and meningococcemia with sulfadiazine, Jr. Am. Med. Assoc., 1941, cxvi, 2666-2668. CrossrefGoogle Scholar4. DANIELSSOLOMONJAQUETTE WBSWA: Meningococcic infection in soldiers, Jr. Am. Med. Assoc., 1943, cxxiii, 1-9. Google Scholar5. OLIVERANDERSON CSDG: The treatment of meningococcic meningitis with sulfamerazine, Am. Jr. Med. Sci., 1944, ccviii, 597-602. CrossrefGoogle Scholar6. GOLDRINGMAXWELLHARTMANN DRAF: Diagnosis and management of severe infections in infants and children: a review of experiences since the introduction of sulfonamide therapy. III. Meningococcal infections, Jr. Pediat., 1945, xxvi, 1-31. Google Scholar7. BENEDICT SR: The determination of blood sugar, Jr. Biol. Chem., 1925, lxiv, 207. CrossrefGoogle Scholar8. DOWLINGLEPPER HFMH: Toxic reactions following therapy with sulfapyridine, sulfathiazole and sulfadiazine, Jr. Am. Med. Assoc., 1943, cxxi, 1190-1194. CrossrefGoogle Scholar9. DOWLINGDUMOFF-STANLEYLEPPERSWEET HFEMHLK: Relative toxicity of sulfamerazine and sulfadiazine, Jr. Am. Med. Assoc., 1944, cxxv, 103-105. CrossrefGoogle Scholar10. SWEETDUMOFF-STANLEYDOWLINGLEPPER LKEHFMH: The treatment of pneumococcic meningitis with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 263-267. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication March 26, 1945.From the Infectious Disease Service and the George Washington Medical Division, Gallinger Municipal Hospital, and the Departments of Pediatrics and Medicine, George Washington University. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeningokokkeninfektionenREFERENCESAcute meningococcemia 1 September 1945Volume 23, Issue 3Page: 338-348KeywordsDrugsHospital medicineInfectious diseasesMeningitisPediatrics ePublished: 1 December 2008 Issue Published: 1 September 1945 PDF downloadLoading ...

PENICILLIN IN THE TREATMENT OF PNEUMOCOCCIC MENINGITIS

During a period of nearly thirty-five years the members of the Division of Acute Infections of the Central Nervous System of the New York City Health Department have been studying the effect of the various forms of therapy in bacterial meningitis. Before the newer chemicals became available the case fatality in pneumococcic meningitis was 100 per cent. The use of azosulfamide and sulfanilamide slightly improved the prognosis. The advent of the more potent sulfonamides marked a further advance in the treatment of this disease. In an unpublished series of 139 cases of pneumococcic meningitis treated with sulfapyridine, sulfadiazine, sulfathiazole or a combination of these (and specific serum when available) we obtained 49 recoveries. The recent introduction of penicillin led us to try the use of this drug in pneumococcic meningitis. MATERIAL This report is based on a series of 67 consecutive cases seen between Oct. 10, 1943 and May 1,

RECURRENT PNEUMOCOCCIC MENINGITIS FOLLOWING SULFONAMIDE THERAPY

Pneumococcic meningitis in the past has been an extremely fatal condition, a review of cases recorded before 1937 revealing only 185 cures in the entire literature.1This discouraging situation has been greatly modified by the use of chemotherapeutic agents. The wise use of sulfonamides early in pneumococcic pneumonia and other pneumococcic infections has prevented an undetermined number of meningeal complications, and the intensive use of these drugs has resulted in many apparent cures of well established pneumococcic meningitis. In addition it appears that occasionally the use of sulfonamide drugs may result in arrest of meningeal manifestations without cure, and that temporary remissions may be followed by relapses displaying typical signs of meningitis of greater or less severity. This relapsing form of pneumococcic meningitis may be regarded as a new clinical phenomenon which has thus far been reported in only 3 cases2and in each instance after more

Penicillin therapy of pneumococcic meningitis: Report of a case with recovery following intraspinal, intracisternal, and intraventricular administration of penicillin

Penicillin therapy of pneumococcic meningitis: Report of a case with recovery following intraspinal, intracisternal, and intraventricular administration of penicillin

THE TREATMENT OF PNEUMOCOCCIC MENINGITIS WITH PENICILLIN

Pneumococcic meningitis remains as one of the acute infections most difficult to treat successfully. Before the introduction of the sulfonamides it was almost invariably fatal. Even with the very vigorous use of sulfonamides and type specific serums the results have been far from satisfactory. The case fatality rate has been reported to vary from 58 per cent¹to 80 or 90 per cent,²depending on the type of case received in the institution in which the study was made. Since pneumococci are highly sensitive to small amounts of penicillin, and since this agent is very effective in pneumococcic pneumonia,³much can be expected from its employment in pneumococcic meningitis.² Our purpose in the present report is to detail our experience with the use of penicillin in the treatment of 16 patients with pneumococcic meningitis and to compare the results with those obtained in 40 consecutive patients

COMBINED PENICILLIN AND SULFONAMIDE THERAPY

Before the advent of chemotherapy, pneumococcic meningitis was an almost invariably fatal disease. Recoveries were rare. The mortality was greater than 99 per cent. In 1927 a review of the literature revealed only 150 recoveries. 1 With the appearance of the sulfonamides the mortality rate for the first time seemed less forbidding, varying, according to different authors, from 31 per cent to 80 per cent. 2 Since 1937 the use of type specific antipneumococcic rabbit serum in conjunction with sulfonamide therapy (sulfapyridine, sulfathiazole, sulfadiazine, sulfapyrazine and sulfamerazine) has come into fashion. There again reports of the comparative advantages of combined serum and sulfonamide therapy as opposed to sulfonamides alone are somewhat equivocal. Certainly the advantages of combined therapy are not particularly striking, and in many cases the overzealous use of serum may be actually deleterious. The use of intrathecal serum, for example, is probably ill advised, as is the pushing

PNEUMOCOCCIC MENINGITIS

Prior to the introduction of the sulfonamide compounds pneumococcic meningitis was almost invariably fatal. With the advent of these drugs, particularly sulfapyridine and sulfadiazine, the prognosis for patients with meningitis of this type was considerably improved. The introduction of penicillin marked another advance in the treatment of this disease. However, the number of reported recoveries from pneumococcic meningitis following penicillin therapy has up to the present time remained small. It has therefore seemed worth while to place on record our case, admission revealed an injected pharynx and a temperature of 102.6 F. Sulfadiazine was prescribed, but after the first dose of the drug a generalized convulsion supervened, lasting thirty or forty minutes. Sulfadiazine therapy was discontinued. The infant's condition remained stationary for the next twenty-four hours. However, the convulsions recurred the next morning, and the infant was brought to the emergency room of the hospital. The history of the birth,

THE TREATMENT OF INTRACRANIAL INFECTIONS WITH PENICILLIN

Penicillin, the powerful antibacterial agent produced by growth of the fungus Penicillium notatum, has been used with dramatic results in cases of infections heretofore usually fatal to man. Until the advent of the sulfonamides it was rare for persons with pneumococcic or staphylococcic meningitis to survive. Reports of such survivals have appeared in the literature more frequently since these agents have been used, but penicillin seems to offer more hope for cure of these maladies than any other substance known at the present time. Two cases of staphylococcic meningitis and 1 case of pneumococcic meningitis are herewith reported as having been cured with penicillin at Lawson General Hospital. It is felt that survival would not have occurred with the types of therapy in practice prior to the advent of penicillin. REPORT OF CASES Case 1.— Pneumococcic (type 18) meningitis . A white man aged 35, admitted to the hospital on Aug.

RECURRENT PNEUMOCOCCIC MENINGITIS TREATED WITH SULFONAMIDES: CASE REPORT

Case Reports1 February 1944RECURRENT PNEUMOCOCCIC MENINGITIS TREATED WITH SULFONAMIDES: CASE REPORTHENRY HOPKINS, M.D., L. C. HATCH, M.D., H. P. SCHENCK, M.D., D. S. PEPPER, M.D., F.A.C.P.HENRY HOPKINS, M.D.Search for more papers by this author, L. C. HATCH, M.D.Search for more papers by this author, H. P. SCHENCK, M.D.Search for more papers by this author, D. S. PEPPER, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-20-2-333 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to the introduction of the sulfonamide group of drugs, pneumococcic meningitis was almost invariably fatal. Prior to 1937 there were 185 reported cures. Since the introduction of these drugs, there have been more than that number of reported cures. We have recently used sulfapyridine and sulfathiazole in the treatment of a patient who had three attacks of pneumococcic meningitis following acute sinusitis. We have been unable to find any similar case reported. Elvidge and Roseman1used sulfapyridine successfully in treating a patient who had three attacks of meningitis following a skull fracture. Craddock and Bowers'2patient had four episodes...Bibliography1. ELVIDGEROSEMAN ARE: Recurrent pneumococcic meningitis complicating skull fracture, Canad. Med. Assoc. Jr., 1940, xlii, 460. Google Scholar2. CRADDOCKBOWERS GBRV: Recurrent pneumococcic meningitis treated with sulfapyridine, Jr. Am. Med. Assoc., 1941, cxvi, 296-298. CrossrefGoogle Scholar3. SPINKHANSEN WWAE: Sulfathiazole: clinical evaluation, Jr. Am. Med. Assoc., 1940, cxv, 840-847. CrossrefGoogle Scholar4. SADUSKBLAKESEYMOUR JFFGA: Observations on the absorption, excretion, diffusion, and acetylation of sulfathiazole in man, Yale Jr. Biol. and Med., 1940, xii, 681-696. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, Pennsylvania*Received for publication August 27, 1941.From the Medical Division of the Hospital of the University of Pennsylvania. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPNEUMOCOCCAL MENINGITIS — A KILLING DISEASEFour recurrent attacks of pneumococcus meningitiswith recoveryThe treatment of pneumococcal meningitis 1 February 1944Volume 20, Issue 2Page: 333-339KeywordsDrugsMeningitisPatientsSkullSulfonamide ePublished: 1 December 2008 Issue Published: 1 February 1944 PDF downloadLoading ...

MENINGOCOCCIC INFECTIONS; REPORT OF 43 CASES OF MENINGOCOCCIC MENINGITIS AND 8 CASES OF MENINGOCOCCEMIA

Excerpt Recent reports indicate that there has been a marked increase in the incidence of cerebrospinal fever in Great Britain since the outbreak of the present war and similar increases have been ...

Pneumococcic meningitis and endocarditis Following fracture of the skull

In this report, we have seen a fracture of the skull which was followed by pneumococcic pneumonia type VII and meningitis. Although the meningitis improved upon sulfapyridine therapy, the patient succumbed to a pneumococcic type VII endocarditis superimposed on an old rheumatic heart lesion which was demonstrated upon autopsy.

SIXTY CASES OF PNEUMOCOCCIC MENINGITIS TREATED WITH SULFONAMIDES

In 1939 one of us 1 reported 17 cases of pneumococcic meningitis treated with sulfapyridine at Sydenham Hospital between October 1938 and May 1939 with recovery of 8 patients (47 per cent). We have since then had occasion to treat 43 more patients at Sydenham Hospital and at the Harriet Lane Home of the Johns Hopkins Hospital. Since there is considerable variation in the mortality figures reported in case series from other hospitals 2 it seemed to us worth while to report our own cases and analyze our experience. Prior to the introduction of sulfonamide therapy the mortality in pneumococcic meningitis was nearly 99 per cent. The Goldsteins 3 reviewed the literature in 1927 and were able to collect 150 authentic reports of recovery from this disease. Between 1930 and 1936 no specific therapy was used at Sydenham Hospital and all 29 patients died. From December 1936 to October 1938