Pneumatic Tube System Research Articles

Pneumatic tube transport of trastuzumab in IV bags-Effect of headspace and surfactant on subvisible particle formation.

In hospitals, IV bags can be prepared in advance for logistical and microbial safety reasons in a compounding unit and then transported to wards. Transport of protein drugs using a pneumatic tube system has been reported to result in high particle levels. In this study, pneumatic tube transport of trastuzumab in saline polyolefin bags was compared to delivery by hospital porters using an electric platform truck in an underground tunnel system. The transport was tracked using designed smart labels. Two strategies to prevent particle formation, removing headspace and adding the surfactant polysorbate 20 were evaluated. The transport by pneumatic tube had a higher level of shock and vibration than truck delivery. The total particle count measured using flow microscopy also increased more for pneumatic transport than for transport by vehicle. Removing the headspace decreased particle formation for both transports. Surfactant decreases particles over 10 µm for trastuzumab in saline IV bags but increases the total particle levels. Pneumatic tube transport of saline in polyolefin bags resulted in high particle levels and surfactant increased the total particle count. Removing headspace is a measure that can be incorporated into compounding practices to cover for inadequate surfactant levels in IV bags.

Impact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice

Postproduction handling and in-hospital transportation of antibody drugs cause mechanical stress, including interfacial and shear stress, that can induce antibody unfolding and aggregation. The handling practices differ significantly between hospitals and the impact on protein stability is unknown. For example, the mechanical stress caused by transport via pneumatic tube systems (PTS) on therapeutic antibody aggregation is a potential safety and quality gap.The aim of this study was to investigate whether mechanical stress and PTS transportation in a hospital cause aggregation of five commonly used antibody drugs diluted in infusion bags.Orthogonal analytical methods showed that the handling and PTS transportation in this hospital did not cause aggregation of the investigated mAbs. The absence of aggregation could be explained by the reduction of interfacial stress due to headspace removal from the infusion bags and a mechanical sensor indicated that there was also only a moderate amount of mechanical stress caused by transportation with this particular PTS.Although this case study focuses on five antibody drugs and the practices in one hospital, the work demonstrates how to evaluate whether other handling and transportation practices cause significant mechanical stress that could compromise the quality and safety of antibody drugs.

Validating a Pneumatic Tube System for Blood Product Delivery

Abstract Introduction/Objective Timely delivery of blood products can be of utmost importance to providing quality care. We aimed to validate the use of a high-speed pneumatic tube system (PTS) that was already installed at our hospital. By reducing delivery times, patient resuscitation and survivability can be increased. Methods/Case Report We followed the Association for the Advancement of Blood & Biotherapies (AABB) guidelines to validate a PTS in a large tertiary academic medical center. The requirements include: verifying product suitability, ensuring product integrity, temperature monitoring, transportation time measurements, and proper packaging and tracking of product receipt. We validated the transfer of packed red blood cells (PRBC), plasma, platelets, and cryoprecipitate from the central blood transfusion services lab (BTS) to nursing stations in a separate building up to 1500 feet (>1/4 mile) away using a Swisslog Translogic® PTS Inclusion with foam inside the PTS carriers helped reduce bumps during transit and insulated products from heat. Results (if a Case Study enter NA) The mean temperature of the PRBC was 6.6 degrees Celsius and none exceeded the AABB maximum of 10 degrees Celsius. The mean time for blood products transit to the nursing stations was 3 minutes (m) and 33 seconds (s). The median time was 3m 31s, and it ranged from 2m 18s to 5m 38s. The PTS reduced delivery times of blood products by up to 10-12 minutes compared to manual porters. Conclusion Transporting blood products via PTS is an efficient method that reduces the required manpower and leads to better utilization of resources. However, it is essential to validate the PTS system before implementing it operationally.

An automated method for thrombocyte counting in capillary microsamples.

We aimed to develop an automated, low-volume method for thrombocyte counting in capillary blood using the Sysmex predilution (PD) mode. Microsamples were prepared by resuspension of 50 μL blood in 300 μL DCL CellPack. Thrombocyte counting was done in the impedance (PLT-I) and fluorescence (PLT-F) channels. The imprecision and bias was evaluated in >394 microsamples from adult blood. Preanalytical factors (skin-piercing, storage, and transportation in our pneumatic tube system) was assessed, and studies on pediatric microsamples were made for comparison. The improvement in analytical quality and turnaround time was examined. For PLT-F, the imprecision was 1.1%-3.7%, and the bias was 10.1% (95% CI: 8.8-11.3). After skin-piercing, the bias was 8.1% (95% CI: 5.6-10.6) and the imprecision 1.9% (95% CI: 1.3-2.5). Thrombocyte counts kept stable after 4 h at room temperature (94.8% [95% CI: 93.2-96.4]) and after pneumatic tube transportation [6.7% (95% CI: 4.8-8.6)]. The bias of the PD mode for pediatric microsamples was 13.0% (95% CI: -8.4-34.4) in the PLT-F channel. The automated method had a considerably lower imprecision than the existing manual thrombocyte counting method and reduced turnaround times. The automated microsample method offers a low-volume alternative for measurement of thrombocytes. The method appears useful also in pediatric samples.

Validation of a single specimen pneumatic tube system in the clinical laboratory.

The single-specimen pneumatic tube (PTS) is a commonly used rapid specimen delivery system in modern clinical laboratories. However, its impact on sample integrity and laboratory test results remains controversial. The installation and configuration of single-specimen PTS are unique to their institution. We sought to validate our single-specimen PTS by comparing routine chemistry, immunology, and hematology results with a repeat sample integrity index for manual transport. In 2023, 30 employees were randomly selected from the company medical examination, and three tubes of procoagulant serum samples and three tubes of EDTA anticoagulant blood samples were collected from each of them. Group A uses a single specimen PTSat 8m/s, Group B uses a single specimen PTSat 15m/s, and Group C uses manual transfer. Specimens from all three groupswere simultaneously analysedfor ALT, AST, TG, TC, LDL, K, NA, CI, TSH, hs-cTnT, NSE, Cyfra21-1 and haematological analysis. The differences between the three groups of NSE and Cyfra21-1 were statistically significant (P <0.05). The differences of the rest of the items were not statistically significant. The difference in NSE was not statistically significant between groups A and B (P =0.401), B and C, and C and A (P <0.05). The difference in Cyfra21-1 was not statistically significant between groups A and B (P =0.897), B and C (P =0.052), and C and A (P =0.145). Individual sample PTS should be validated for testing prior to use to ensure the results' accuracy.

Reaping Benefits and Overcoming Challenges in Pneumatic Tube System Adoption for Hospital Logistics: Learnings from a Decade of Utilization

Reaping Benefits and Overcoming Challenges in Pneumatic Tube System Adoption for Hospital Logistics: Learnings from a Decade of Utilization

Comparison of the speed and quality of innovative and traditional pneumatic tube system transport outside of an emergency laboratory

BackgroundEnsuring the rapidity and accuracy of emergency laboratory test results is especially important to save the lives of patients with acute and critical conditions. To better meet the needs of clinicians and patients, detection efficiency can be improved by reducing extra-laboratory sample turnaround times (TATs) through the use of innovative pneumatic tube system (PTS) transport for sample transport. However, concerns remain regarding the potential compromise of sample quality during PTS transit relative to that occurring with manual transportation. This study was performed to evaluate the efficacy of an innovative PTS (Tempus600 PTS) relative to a traditional PTS in terms of sample transit time, sample quality, and the concordance of analytical results with those obtained from manually transported samples. MethodsIn total, 30 healthy volunteers aged >18 years were recruited for this study, conducted for five consecutive days. Venous blood samples were collected from six volunteers per day at fixed timepoints. From each volunteer, nine blood samples were collected into tubes with tripotassium ethylene diamine tetraacetic acid anticoagulant, tubes with 3.2 % sodium citrate, and serum tubes with separation gel (n = 3 each) and subjected to all tests conducted in the emergency laboratory in our hospital. 270 blood samples from 30 healthy volunteers were transported and analyzed, yielding 6300 test results. The blood samples were divided randomly into three groups (each containing one tube of each type) and transported to the emergency laboratory manually and with Tempus600 PTS and conventional Swisslog PTS, respectively. The extra-laboratory TATs, sample quality, and test results of the transported blood samples were compared. ResultsThe sample quality and test results did not differ according to the delivery method. The TAT was much shorter with the Tempus600 than with the other two transport modes (58.40 ± 1.52 s vs. 1711.20 ± 77.56 s for manual delivery and 146.60 ± 1.82 s for the Swisslog PTS; P = 0.002). ConclusionBlood sample transport with the Tempus600 PTS significantly reduced the extra-laboratory TAT without compromising sample quality or test result accuracy, thereby improving the efficiency of sample analysis and the services provided to clinicians and patients.

Physicochemical and biological stability of diluted vedolizumab in intravenous infusion bags

IntroductionIntravenous vedolizumab is a widely used monoclonal antibody for outpatients with inflammatory bowel disease. Drug preparation is performed on the day of administration, but is time consuming, causing unnecessary in-hospital...

Towards a Digital Predictive Maintenance (DPM): Healthcare Case Study

This paper presents a global approach for implementing Digital Predictive Maintenance (DPM), based on the principles of the digital industry. The proposed approach is applicable at both academic and professional scales, across all sectors and all sizes of organisations. This approach consists of four main phases: the identification of the system or work environment, the identification of the specific targets that justify the adoption of digital maintenance, the choice of appropriate digital technologies for predictive maintenance and the implementation of maintenance X.0 at all levels (i.e., strategic, tactical and/or operational). To validate this approach, the healthcare sector was chosen as a field of application. The uninterrupted operation of facilities and equipment in this sector is paramount. The adoption of maintenance X.0, which has already demonstrated significant benefits in other sectors, would be of great value in the healthcare sector. By applying our approach to the Pneumatic Tube System (PTS) at the Ibn Sina University Hospital Center (actually) in Rabat, Morocco, we have succeeded in introducing a structured and streamlined implementation of DPM in the healthcare sector.

Comparative Validation Study between Pneumatic Tube System and Hand Carried Blood Sample

Rapid delivery of specimens is crucial in today's clinical laboratories, and pneumatic tube systems are commonly utilized for this purpose. The validation of sample stability through pneumatic tube system (PTS) is essential. The use of Pneumatic Tube System can improve specimen turnaround time; allowing more effective time management of the porters by reducing the need to physically take specimens from one department to another. Prior to use, the Pneumatic tube system must be validated to ensure the reliability of laboratory test results, particularly those impacted by movement, such as lactate dehydrogenase (LDH), aspartate aminotransferase (AST), potassium (K+), complete blood count (CBC), particularly hemoglobin and coagulation tests. The most common way of validating pneumatic tube systems is to compare blood samples transported by pneumatic tube systems to blood samples transported by hand. High speeds and rapid acceleration of blood samples can increase the risk of hemolysis and negatively affect sample quality and test results. Moreover, the installation and design of each pneumatic tube system exhibit unique characteristics that are exclusive to each individual institution. The established protocol necessitated the use of either a human courier or pneumatic tube technology in order to transport a collection of replicated samples to the laboratory. Comparative research will be conducted on a sample size of twenty healthy adult volunteers to assess the integrity of the sample. The main objective of our study was to evaluate the effects of PTS transportation on laboratory results and whether is there any difference as compared to hand courier method.

Influence of pneumatic tube delivery system on laboratory results.

The pneumatic tube system (PTS) is an automated and fast modality of transportation of biological samples, but it has been reported to induce preanalytical errors. To study the influence of transportation by PTS on biochemistry tests which are particularly sensitive to haemolysis and atmospheric pressure variation. We compared laboratory results of arterial blood gas, sodium, potassium, chloride, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, glucose and haemolysis index of samples conveyed simultaneously by PTS and by courier. We recruited 30 patients from the sampling room and 40 patients from the intensive care unit. Transport through PTS resulted in a significant increase in aspartate aminotransferase and potassium without exceeding the limits of acceptability. Potassium was significantly more increased for samples transported in a higher speed line (p = .048) but without exceeding the limits of acceptability. No significant impact was noted on haemolysis indices. The pO2 variations due to PTS transportation exceeded the limit of acceptability with significant intra-individual variations. Our PTS is validated for biochemistry tests results. It reduces turnaround times without affecting sample quality. However, the interpretation of arterial blood gas results should be careful for samples transported by PTS.

Transportation of mAb Dosing Solution in Intravenous Bag: Impact of Manual, Vehicle, and Pneumatic Tube System Transportation Methods on Product Quality.

Monoclonal antibody (mAb) products for intravenous (IV) administration generally require aseptic compounding with a commercial diluent within a pharmacy. The prepared dosing solution in the IV bag may be transported to the dosing location via manual, vehicular, pneumatic tube system (PTS), or a combination of these methods. In this study, the type and level of physical stresses associated with these three methods and their product quality impact for relatively sensitive and stable mAbs were assessed. Vibration was found to be the main stress associated with manual and vehicle transportation methods, although this was at a relatively low level (<1 GRMS/Root-Mean-Square Acceleration). Shock and drop events, at relatively low levels, were also observed with these methods. PTS transportation showed substantially more intense shock, vibration, and drop stresses and the measured levels were up to 91 G/force of acceleration or deceleration, 3.7 GRMS and 39 G, respectively. Using a foam padding insert for PTS transportation reduced the shock level considerably (91 G to 59 G). Transportation of mAb dosing solutions in IV bags via different methods including PTS transportation variables caused a small increase in the subvisible particle counts and there was no change in submicrometer particle distribution. No visible particles and no significant change to soluble aggregate levels were observed after transportation. Strategies such as removal of IV bag headspace prior to transport and in-line filtration poststress reduced the subvisible particles counts. All tested transportation conditions showed negligible impact on other product quality attributes tested. Removal of IV bag headspace prior to PTS transport prevented formation of micro air bubbles and foaming compared to the unaltered IV bag. This study shows examples where manual, vehicle, and PTS transport methods did not significantly impact product quality, and provides evidence that mAb products that are appropriately stabilized in the dosing solution (e.g., with a surfactant) can be transported via a PTS.

Improving the Logistics of Institutional Postal Services

Postal services are often considered by the different institutions as a back-up service. Taking into account that in case of large geographical coverage these services can generate significant costs, it is important to optimize the postal service functions within these institutions and to develop the already existing conventional postal services. Within the frame of this article the authors review the logistics processes of the postal services at the University of Miskolc to propose improvements to the processes of postal services focusing on delivery. The main regulatory elements and the logistics processes of the institutional postal services are discussed and some critical remarks are described focusing on three main areas: the facility location optimization of the institutional postal services, the lack of use of modern technologies and the lack of modern administrative facilities. On the basis of these criticisms, the authors define recommendations for improving institutional postal services. Regarding the facility location optimization problem, a mathematical model and an optimization algorithm is described to evaluate the efficiency of the logistics processes of delivery services. The proposed methodology supports a cost-based analysis of different solution variants and a priority-based differentiation between institutions and offices. The suggested approach is tested with a real scenario, where the numerical results validate the efficiency of the evaluation of optimization algorithm. The second improvement direction is the application of a pneumatic tube system. The authors show the most important parts of the proposed pneumatic tube system, which can lead to decreased labor cost and increased service level.

Diagnostic sample transport via pneumatic tube systems: data logger and their algorithms are sensitive to transport effects.

Many hospitals use pneumatic tube systems (PTS) for transport of diagnostic samples. Continuous monitoring of PTS and evaluation prior to clinical use is recommended. Data loggers with specifically developed algorithms have been suggested as an additional tool in PTS evaluation. We compared two different data loggers. Transport types- courier, conventional (cPTS) and innovative PTS (iPTS)- were monitored using two data loggers (MSR145® logger, CiK Solutions GmbH, Karlsruhe, Germany, and a prototype developed at the University Medicine Greifswald). Data loggers differ in algorithm, recording frequencies and limit of acceleration detection. Samples from apparently healthy volunteers were split among the transport types and results for 37 laboratory measurands were compared. For each logger specific arbitrary units were calculated. Area-under-the-curve (AUC)-values (MSR145®) were lowest for courier and highest for iPTS and increased with increasing recording frequencies. Stress (St)-values (prototype logger) were obtained in kmsu (1,000*mechanical stress unit) and were highest for iPTS as well. Statistical differences between laboratory measurement results of transport types were observed for three measurands sensitive for hemolysis. The statistical, but not clinical, differences in the results for hemolysis sensitive measurands may be regarded as an early sign of preanalytical impairment. Bothdata loggers record this important interval of beginning mechanical stress with a high resolution indicating their potential to facilitate early detection of preanalytical impairment. Further studies should identify suitable recording frequencies. Currently, evaluation and monitoring of diagnostic sample transport should not only rely on data loggers but also include diagnostic samples.

Impact of blood collection devices and mode of transportation on peripheral venous blood gas parameters

BackgroundPeripheral venous blood (PVB) gas analysis has become an alternative to arterial blood gas (BG) analysis in assessing acid-base balance. This study aimed to compare the effects of blood collection devices and modes of transportation on peripheral venous BG parameters. MethodsPVB-paired specimens were collected from 40 healthy volunteers into blood gas syringes (BGS) and blood collection tubes (BCT), transported by either a pneumatic tube system (PTS) or human courier (HC) to the clinical laboratory, and compared using a two-way ANOVA or Wilcoxon signed-rank test. To determine clinical significance, the PTS and HC-transported BGS and BCT biases were compared to the total allowable error (TEA). ResultsPVB partial pressure of oxygen (pO2), fractional oxyhemoglobin (FO2Hb), fractional deoxyhemoglobin (FHHb), and oxygen saturation (sO2) showed statistically significant differences between BGS and BCT (p < 0.0001). Compared to HC-transported BGS and BCT, statistically significant increases in pO2, FO2Hb, sO2, oxygen content (only in BCT) (all p < 0.0001), and base excess extracellular (only in BCT; p < 0.0014) concentrations and a statistically significant decrease in FHHb concentration (p < 0.0001) were found in BGS and BCT delivered by PTS. The biases between PTS- and HC-transported BGS and BCT exceeded the TEA for many BG parameters. ConclusionsCollecting PVB in BCT is unsuitable for pO2, sO2, FO2Hb, FHHb, and oxygen content determinations.

A Comparative Study of PTS and Manual Transportation for Platelet Count and Aggregation Test

The transportation effect of the Pneumatic Tube System (PTS) on platelet activity remains controversial. This study aimed to analyze the effect of PTS in the platelet aggregation test in Dr. Cipto Mangunkusumo Hospital, Jakarta. This cross-sectional study was carried out in the Clinical Pathology Laboratory of Dr. Cipto Mangunkusumo Hospital (RSUPNCM) from March to April 2021. There were 50 subjects involved in this study, each of whom 6 sodium citrate blood tubes were extracted. Three tubes were sent through PTS while the rest were transported manually. All tubes were then tested for platelet count and platelet aggregation using ADP agonists of 1 uM, 5 uM, and 10 uM. There was a lower platelet count (p=0.046) and platelet aggregation in ADP 1 uM (p=0.037), ADP 5 uM (p &lt;0.001), and ADP 10 uM (p &lt;0.001) at PTS-transported samples. Eleven samples were interpreted distinctively as low platelet aggregation in PTS transportation became normal in manual delivery. Cohen’s Kappa value was 0.51 (p &lt;0.001). A decreasing platelet count and platelet aggregation in PTS samples indicated that acceleration and deceleration during transportation could lead to platelet activation, thus resulting in a lower result after being added to an agonist. Cohen's Kappa test showed that manual transportation could not be replaced with PTS for the platelet aggregation test. Platelet count and platelet aggregation were found to be lower in PTS-transported samples. It was suggested to centralize specimen taking for platelet aggregation tests, thus manual transportation can be conducted more efficiently.

역압을 이용한 공압 튜브 캐리어 도착 속도 조절 연구

A pneumatic tube system is a system that transmits and receives objects quickly inside pipes and is used in urgent situations or when transferring or returning objects. It is mainly used in hospitals, large marts, and automation systems. For long-distance transportation (up to 10 km) high pressure is used at industrial plant industrial sites. A large amount of flow rate and high pressure are used to generate instantaneous pressure and flow to the opposite side, where the transport target is stored in a separately manufactured carrier and transported. Specially manufactured carriers considering significant frictional force in the straight, curved, rising, and lower sections during long-distance transport are employed. The other party experimentally generates reverse pressure to lower the care speed inside the transfer pipe that arrives at a high speed and operates the worker valve to reduce the speed, but the valve must be operated every time according to pressure and distance changes. In the present work, a method of arriving at a carrier in a stable pipe through speed reduction by controlling the flow rate and reverse pressure depending on the distance from the transmission unit and calculating the reverse pressure compared to the teleportation speed is presented.

Effects of centrifugation prior to pneumatic tube system transport on routine biochemical and immunological tests of susceptibility to hemolysis

BackgroundPneumatic tube system (PTS) may be associated with preanalytical hemolysis. The objective of this study was to evaluate the effects of PTS on biochemical and immunological tests susceptible to hemolysis and try to find ways to reduce the result bias caused by PTS. MethodsLaboratory parameters were compared between PTS without centrifuging group, PTS after centrifuging group, PTS with serum group, and hand-delivered (HD) group. Studies were performed to access the influence of different PTS transport frequencies on laboratory assays. ResultsPTS transportation resulted in obviously increase in LDH (lactate dehydrogenase) and NSE (neuron-specific enolase) results (LDH: Bias = 17.95%, 95% confidence interval (CI) = −3.13–39.02; p < 0.001; NSE: Bias = 64.26%, 95% CI = −21.29–149.82; p < 0.001; respectively). After pre-centrifugation, no statistical difference was observed in LDH results (Bias = 2.83%, 95% CI = −13.00–18.65; p = 0.737). However, the bias of NSE still reach 19.16% (95% CI = −41.78–80.11), which exceeded the clinical acceptable range (p = 0.017). Both LDH(p = 0.931) and NSE(p > 0.999) show no statistical difference between PTS with serum group and HD group (LDH: Bias = −1.60%, 95% CI = −6.00–2.81; NSE: Bias = −3.68%, 95% CI = −11.35–3.99). ConclusionPTS can lead to falsely increased LDH and NSE test results. Only loading the centrifuged upper serum in new tubes during PTS transport can eliminate the results bias of NSE.

1010: IMPACT OF USP-800 ON ADMINISTRATION TIMES OF HAZARDOUS INTRAVENOUS ANTIEPILEPTIC MEDICATIONS

Introduction: USP general chapter < 800> establishes comprehensive guidelines for safe handling of hazardous drugs, including some antiepileptics, by healthcare personnel. This guidance increases the number of steps required to safely compound and deliver medications, potentially resulting in a delay of care for time-sensitive medications. The aim of this study is to assess the impact that implementation of USP < 800> had on the timeliness of administration of antiepileptic medications at an academic medical center. Methods: A single center, retrospective study of time from verification to administration pre- and post-USP < 800> implementation of adult one-time orders of intravenous (IV) fosphenytoin (FOS), phenytoin (PHT), and valproic acid (VPA) was conducted. The study period includes 10 months immediately prior to adoption of USP < 800> and five months post adoption. One-time orders were included if scheduled administration time was within 90 minutes of verification. The primary outcome was time in minutes from order verification to medication administration. Subgroup analyses compared the results based on method of medication delivery (pneumatic tube system (PTS) vs hand delivery) and if orders were designated as “STAT”. Results: A total of 248 orders met inclusion criteria: 33 FOS, 12 PHT, and 203 VPA, (pre: 176, post: 72). Time from verification to administration was 15 minutes longer in the post-implementation group for aggregate antiepileptic orders (54 [35-72] vs 69 [48-90], p=0.0013). This increase in time to administration post-implementation was comparable across each of the medications assessed. Subgroup analysis of orders marked as “STAT” showed a similar increase in median time to administration (43 [28-65] vs 56 [34-86], p=0.0406). There was no difference in time to administration comparing PTS to hand delivery (71 [46-109] vs 68 [51-88], p=0.6603). Conclusions: Implementation of USP < 800> increased the median time from order verification to administration for three hazardous IV antiepileptic medications. In patients with status epilepticus, a 15 minute delay could prolong time to seizure termination resulting in worse clinical outcomes. Institutions will need to develop alternative methods for compounding and delivery to ensure timely administration while maintaining safety.

Comparison between use courier transport with pneumatic tube system on the results of routine hematology test, Prothrombin Time (PPT), Activated Partial Thromboplastin Time (APTT), and potassium

Pneumatic tube system (PTS) is a transport medium that is widely used in hospitals. The samples transported via PTS would get vibrations due to changing air velocity and pressure. This unstable pressure could cause pre-analytic errors in laboratory measurements. It happened because it damages erythrocytes and lymphocytes and causes haemolysis. It has been demonstrated that these changes can alter the quality of samples and induce haemolysis by leading primarily to increase in lactate dehydrogenase (LDH) concentrations, and potassium concentration. Haemolysis is dined as the release of intracellular components of erythrocytes and other blood cells into the extracellular space of blood. It can also affect the results of in vitro platelet function test. Incorrect test results can affect the diagnosis and the treatment for patients Every hospital that uses PTS are advised to validate and investigate that PTS has the possibility of haemolysis and impacts laboratory results of blood specimens. The purpose of the study was to validate and know comparison between use courier transport with using PTS on the results of routine haematology tests, PPT, APTT, and potassium. This research was experimental research by using posttest without control. The research used statistical test which was paired t-test. The research was conducted at the Integrated Clinical Laboratory Installation of the Gadjah Mada University Academic Hospital in August – October 2020 with 30 preoperative patients. Data were analysed with Prism GraphPad 8 software. There was no significant difference between WBC, RBC, Hb, HCT, MCV, MCH, MCHC, PPT, and APTT. Moreover, there was a significant difference between the results of PLT and potassium in the samples transported via PTS and delivered by courier transport.