The coupling and pneumatic compressibility effects cause strong parameter variety in a two-input two-output(TITO) pneumatic control system.Thus, it is difficult to design a controller using conventional control method.In this paper, self-organizing fuzzy control (SOFC) is applied to a TITO pneumatic position control system.By using the concept of decentralized control, a TITO control structure is decomposed into two separate control channels.Each channel is associated with a SOFC for single-axial pneumatic control system and a decoupling SOFC for structure interactions.Experimental results show that the proposed control algorithm can achieve high control accuracy.And, it robust to various operating conditions.