The China Fusion Engineering Test Reactor cryogenic system mainly provides necessary supercritical helium for cooling superconducting coils and structure to transfer the static thermal load and the dynamic thermal load generated during plasma operation mode. According to the conceptual design of CFETR cryogenic system, the cooling capacity at 4.5 K is about 125 kW, with five 25 kW@4.5 K helium refrigerators in parallel. As one of the main components, a horizontal cold box provides a vacuum and insulating working environment for plate-fin heat exchangers, turbines, adsorbers, control valves and pipes. This paper presents a preliminary structural design for the 25 kW@4.5 K helium refrigerator horizontal cold box. The structural strength and static heat leakage of the cold box including support seats are analyzed through the finite element simulation method. The simulation results further verify the rationality and feasibility of the cold box structure design, and provide a certain reference for the subsequent detailed engineering design.