The aim of this study is to obtain the nonlinear and post-buckling responses of relatively thick functionally graded plates with oblique elliptical cutouts using a new semi-analytical approach. To model the oblique elliptical hole in a FGM plate, six plate-elements are used and the connection between these elements is provided by the well-known Penalty method. Therefore, the semi-analytical technique used in this paper is known as the plate assembly technique. In order to take into account for functionality of the material in a perforated plate, the volume fraction of the material constituents follows a simple power law distribution. Since the FGM perforated plates are relatively thick in this research, the structural model is assumed to be the first order shear deformation theory and Von-Karman\'s assumptions are used to incorporate geometric nonlinearity. The equilibrium equations for FGM plates containing elliptical holes are obtained by the principle of minimum of total potential energy. The obtained nonlinear equilibrium equations are solved numerically using the quadratic extrapolation technique. Various sets of boundary conditions for FGM plates and different cutout sizes and orientations are assumed here and their effects on nonlinear response of plates under compressive loads are examined.