In this study, a 2018 anthropogenic volatile organic compounds (VOCs) emission inventory in Hubei Province was conducted using the emission factor method based on activity levels of five sources. The emission characteristics and variation trends of process sources from 2009 to 2018 were further analyzed. Total anthropogenic VOCs emissions were 6.52×105 tons in Hubei Province, accounting for about 6.41% of the country's total omissions. The contributions of fossil combustion sources, process sources, solvent sources, mobile sources, and waste disposal sources were 3.26%, 76.39%, 4.54%, 14.72%, and 1.09%, respectively. Process sources involving 45 sub-categories of nine industries accounted for a significant proportion of VOCs emissions, with Wuhan and Yichang recording the highest VOCs emission levels. The VOCs emissions intensity of each city and state were analyzed based the level of economic activity and territorial area. Tianmen and Shennongjia had higher VOCs emissions per unit of GDP, while Wuhan, Ezhou, and Tianmen had higher VOCs emissions per unit area. Regarding process source contributions, VOCs emissions increased progressively to 2.45×105 tons in 2009 and then stabilized between 2015 and 2017 with maximum emissions of 7.01×105 tons. In 2018, VOCs emissions decreased to 4.98×105 tons. This trend was similar to national anthropogenic emissions. Two industrial sectors, namely chemical raw materials and rubber and plastics, were the main driving force with contributions of 33.85%-51.55% and 7.07%-38.13%, respectively. Among them, the production of chemicals and active pesticide and pharmaceutical ingredients played an important role in contributing to VOCs emissions, while emissions during foam plastics production varied greatly, increasing sharply to more than 2.00×104 tons in 2015-2017. Under the guidance of the relevant national and local policies, emissions from key industries were significantly reduced in Hubei Province.