Abstract Introduction/Objective T-cell Lymphoma is overly aggressive. T cells overgrow triggered by aberrant T-cell signaling and transform into a lymphoma. Virus infection contributes to the transformation, for example, EBV (Epstein Barr Virus) virus is associated with Extranodal NK/T-cell lymphoma, Angioimmunoblastic T-cell lymphoma, and peripheral T-cell lymphoma, HHV-8 is associated with Primary Effusion Lymphoma, Kaposi sarcoma, and very rarely associated with T cell lymphoma. The HIV (Human Immunodeficiency Virus) virus is associated with Burkitt lymphoma, Plasmablastic lymphoma et al. Among these lymphomas, only Primary Effusion lymphoma is associated with all three virus infections and is a B cell lymphoma. T cell lymphoma with all three infections has not been reported. Since most patients are diagnosed with advanced disease. So early diagnosis of this disease is especially important. Methods/Case Report An HIV+ 38-year-old male with no significant medical history complained of weakness, dizziness, and presenting with lower extremities swelling, and anemia for the last 2 weeks. The patient had a history of an unsafe sexual encounter with male sex workers but denies iv. drug use and blood transfusion. The screen before endoscopy reveals active, acute Hepatitis B Virus infection. Endoscopy findings show gastritis. The biopsy specimen shows mucosa is diffusely infiltrated by atypical plasmablastic cells. Immunostaining reveals they are positive for CD3, CD7, CD30, MUM1, CD43, and HHV8, but negative for Cd2, Cd4, Cd5, Cd8, Cd10, Cd21, Cd23, Cd25, Cd34, Cd56, Cd138, CD19, CD20, CD79a, PAX5, CD45, CD57, P53, CyclinD1, BCL6, BCL2, ALK, c-MYC, TdT, Granzyme B, TIA, S-100, Pancytokeratin. In situ hybridization for EBER is positive, but negative for Kappa and Lambda. The proliferative index (Ki-67) is high (99%). The morphologic and immunophenotypic features are consistent with an EBV CD30+ high-grade lymphoma. The sequencing from OnkoSightTM Advanced Chronic Lymphoid NGS Report shows a BCL-6 and EP300 mutation that has not been reported in a publicly available database (COSMIC; gnomAD). Results (if a Case Study enter NA) N/A. Conclusion To our knowledge, this is the first reported case of EBV+/HHV-8+/HIV+ high grade T Cell Lymphoma in the stomach. This type of lymphoma is extremely aggressive, and the early diagnosis is particularly important for prognosis.