Objective: to evaluate the outcomes of endoscopic ovarian drilling (LOD) on the Anti Mullerian hormone (AMH)plasma levels, potential changes of the stromal ovarianblood flow, and antral follicular count by three-dimensionalpower Doppler ultrasonography in an-ovulatory polycysticovarian disease (PCOD) and if this can explain the ovariandrilling mechanism of action.Methods: The prospective, comparative (case control) research was completed on fifty patients from Bab El-ShaareaUniversity Hospital (El Sayed Galal). They were selectedfrom infertility and family planning clinics. Women wereassigned into one of two equal groups (each 25 patients).The first included infertile women, resistant to clomiphenecitrate and scheduled for drilling. The second includedhealthy women from the family planning clinic, who wereseeking for contraception. The main outcomes were AMHlevels, Doppler indices and Antral follicular counts beforeand after drilling. The secondary outcome in the studygroup included occurrence of ovulation, chemical and clinical pregnancy rate within 6 months after drilling.Results: The mean initial AMH, doppler indices and antral follicular counts were singingly higher among studythan control group. AMH and AFC significantly reduced incases after than before drilling [2.8 to 3.9], [13.9 to 15.8].Ovarian FI, VI, and VFI significantly decreased after thanbefore drilling. In the study group, 20 (80%) had ovulation,and 13 (52%) got pregnant within 6 months of the operation.Regression analysis showed that initial AMH, initial AFC,initial VFI, post-LOD AMH, post-LOD AFC, post-LOD VI,post-LOD FI and post-LOD VFI were significant indicatorsof successful ovulation and successful pregnancy within 6months after drilling.Conclusion: Endoscopic ovarian drilling had a significantdecreasing effect on serum AMH, AFC, and Ovarian Doppler indices in PCOD patient not responding to clomiphenecitrate. The initial values of AMH, AFC and VFI; besidespost-drilling values of AMH, AFC, VI, FI, and VFI weresignificant indicators of ovulation after drilling.