Plant-derived Agents Research Articles

Immunological Effects of Aster yomena Callus-Derived Extracellular Vesicles as Potential Therapeutic Agents against Allergic Asthma.

Plant-derived extracellular vesicles, (EVs), have recently gained attention as potential therapeutic candidates. However, the varying properties of plants that are dependent on their growth conditions, and the unsustainable production of plant-derived EVs hinder drug development. Herein, we analyzed the secondary metabolites of Aster yomena callus-derived EVs (AYC-EVs) obtained via plant tissue cultures and performed an immune functional assay to assess the potential therapeutic effects of AYC-EVs against inflammatory diseases. AYC-EVs, approximately 225 nm in size, were isolated using tangential flow filtration (TFF) and cushioned ultracentrifugation. Metabolomic analysis, using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS), revealed that AYC-EVs contained 17 major metabolites. AYC-EVs inhibited the phenotypic and functional maturation of LPS-treated dendritic cells (DCs). Furthermore, LPS-treated DCs exposed to AYC-EVs showed decreased immunostimulatory capacity during induction of CD4+ and CD8+ T-cell proliferation and activation. AYC-EVs inhibited T-cell reactions associated with the etiology of asthma in asthmatic mouse models and improved various symptoms of asthma. This regulatory effect of AYC-EVs resembled that of dexamethasone, which is currently used to treat inflammatory diseases. These results provide a foundation for the development of plant-derived therapeutic agents for the treatment of various inflammatory diseases, as well as providing an insight into the possible mechanisms of action of AYC-EVs.

Plant-derived natural compounds as promising anticancer agents in hematological malignancies

The latest treatments have improved outcomes for patients with hematological malignancies, but relapse, treatment resistance and particularly side effects still remain as common limitations of these treatments. Given the disadvantages of the existing conventional therapeutic methods, developing more effective drugs with less toxicity and side effects is of paramount importance. Medicinal herbs have historically proven their worth as a pool of potential therapeutic agents for leukemia and lymphoma, and today they still represent a rich source for the recognition of new drug leads. The role of the positive synergistic effects of plant-derived natural products and common chemotherapeutic drugs is also considered as one of the rational reasons for paying attention to the medicinal plants in recent chemoprevention and chemotherapeutic investigations. Noteworthy, targeted delivery of plant-derived natural products via the incorporation of nanoparticles or antibodies would be a major step to improve their bioavailability and then to increase their therapeutic effects. In this study, we reviewed plant-derived agents approved and/or under investigation for hematological malignancies.

Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1.

Simple SummaryGamma aminobutyric acid (GABA) a non-protein amino acid is an archaic signalling molecule for cellular communication across all kingdoms of life with distinct signalling roles in animals. Emerging research establishes GABA as a signalling molecule in planta. GABA modulates numerous developmental processes and negatively regulates root growth, stomatal aperture, and anion flux under abiotic stress. A putative GABA binding site with homology to the mammalian GABA binding site has been identified in a family of proteins (Aluminium Activated Malate Transporters -ALMT) involved in mediating anion flux and conferring plant aluminium tolerance. Studies have shown that ALMTs are regulated by GABA and transport both anions and GABA. To gain further insights into the mechanism of GABA regulation, it is essential to differentiate between the two transport modes. Pharmacological agents used to characterise mammalian GABA receptors have proved useful in gaining insights into GABA regulation of plant processes. In this study, picrotoxin an inhibitor of anion flux in mammalian GABA receptors was used to investigate the pathways for anion and GABA transport in ALMTs. Results suggest that picrotoxin inhibits anion flux but not GABA flux and can be used to gain further insights into mechanism of GABA regulation of plant proteins.Plant-derived pharmacological agents have been used extensively to dissect the structure–function relationships of mammalian GABA receptors and ion channels. Picrotoxin is a non-competitive antagonist of mammalian GABAA receptors. Here, we report that picrotoxin inhibits the anion (malate) efflux mediated by wheat (Triticum aestivum) ALMT1 but has no effect on GABA transport. The EC50 for inhibition was 0.14 nM and 0.18 nM when the ALMTs were expressed in tobacco BY2 cells and in Xenopus oocytes, respectively. Patch clamping of the oocyte plasma membrane expressing wheat ALMT1 showed that picrotoxin inhibited malate currents from both sides of the membrane. These results demonstrate that picrotoxin inhibits anion efflux effectively and can be used as a new inhibitor to study the ion fluxes mediated by ALMT proteins that allow either GABA or anion transport.

Dialdehyde Starch Nanocrystals as a Novel Cross-Linker for Biomaterials Able to Interact with Human Serum Proteins

In recent years, new cross-linkers from renewable resources have been sought to replace toxic synthetic compounds of this type. One of the most popular synthetic cross-linking agents used for biomedical applications is glutaraldehyde. However, the unreacted cross-linker can be released from the materials and cause cytotoxic effects. In the present work, dialdehyde starch nanocrystals (NDASs) were obtained from this polysaccharide nanocrystal form as an alternative to commonly used cross-linking agents. Then, 5–15% NDASs were used for chemical cross-linking of native chitosan (CS), gelatin (Gel), and a mixture of these two biopolymers (CS-Gel) via Schiff base reaction. The obtained materials, forming thin films, were characterized by ATR-FTIR, SEM, and XRD analysis. Thermal and mechanical properties were determined by TGA analysis and tensile testing. Moreover, all cross-linked biopolymers were also characterized by hydrophilic character, swelling ability, and protein absorption. The toxicity of obtained materials was tested using the Microtox test. Dialdehyde starch nanocrystals appear as a beneficial plant-derived cross-linking agent that allows obtaining cross-linked biopolymer materials with properties desirable for biomedical applications.

Therapeutic Potential of Medicinal Plants against Dengue Infection: A Mechanistic Viewpoint.

Dengue is a tropical disease caused by the Dengue virus (DENV), a positive-sense, single stranded RNA virus of the family Flaviviridae, which is transmitted by Aedes mosquitoes. The occurrence of dengue has grown dramatically around the globe in recent decades, and it is rapidly becoming a global burden. Furthermore, all four DENV serotypes cocirculate and create a problematic hyperendemic situation. Characteristic symptoms range from being asymptomatic, dengue fever to life-threatening complications such as hemorrhagic fever and shock. Apart from the inherent virulence of the virus strain, a dysregulated host immune response makes the condition worse. Currently, there is no highly recommended vaccine or therapeutic agent against dengue. With the advent of virus strains resistant to antiviral agents, there is a constant need for new therapies to be developed. Since time immemorial, human civilization has utilized plants in traditional medicine to treat various diseases, including infectious viral diseases. With the advancement in molecular biology, cell biology techniques, and bioinformatics, recent studies have tried to provide scientific evidence and determine the mechanism of anti-dengue activity of various plant extracts and plant-derived agents. The current Review consolidates the studies on the last 20 years of in vitro and in vivo experiments on the ethnomedicinal plants used against the dengue virus. Several active phytoconstituents like quercetin, castanospermine, α-mangostin, schisandrin-A, hirsutin have been found to be promising to inhibition of all the four DENV serotypes. However, novel therapeutics need to be reassessed in relevant cells using high-throughput techniques. Further, in vivo dose optimization for the immunomodulatory and antiviral activity should be examined on a vast sample size. Such a Review should help take the knowledge forward, validate it, and use medicinal plants in different combinations targeting multiple stages of virus infection for more effective multipronged therapy against dengue infection.

TMT-Based Quantitative Proteomics Analyses Reveal the Antibacterial Mechanisms of Anthocyanins from Aronia melanocarpa against Escherichia coli O157:H7.

Aronia melanocarpa anthocyanins (AMAs), as natural plant extracts, can control pathogens and are attracting increasing attention. In this study, a tandem mass tag (TMT) quantitative proteomics method combined with multiple reaction monitoring (MRM) was used to explore the antibacterial mechanism of AMAs against Escherichia coli at the protein level. The results showed that 1739 proteins were identified in E. coli treated with AMAs, of which 628 were altered, including 262 downregulated proteins and 366 upregulated proteins. Bioinformatics analysis showed that these differentially expressed proteins have different molecular functions and participate in different molecular pathways. AMAs can affect E. coli protein biosynthesis, DNA replication and repair, oxidative stress response, peptidoglycan biosynthesis, and homeostasis. These pathways induce morphological changes and cell death. The results of this study help understand the molecular mechanism of the inhibitory effect of AMAs on food-borne pathogens and provide a reference for further development of plant-derived antimicrobial agents.

Design and Preparation of Avermectin Nanopesticide for Control and Prevention of Pine Wilt Disease.

Pine wilt disease is a devastating forest disaster caused by Bursaphelenchus xylophilus, which has brought inestimable economic losses to the world’s forestry due to lack of effective prevention and control measures. In this paper, a porous structure CuBTC was designed to deliver avermectin (AM) and a control vector insect Japanese pine sawyer (JPS) of B. xylophilus, which can improve the biocompatibility, anti-photolysis and delivery efficacy of AM. The results illustrated the cumulative release of pH-dependent AM@CuBTC was up to 12 days (91.9%), and also effectively avoided photodegradation (pH 9.0, 120 h, retention 69.4%). From the traceable monitoring experiment, the AM@CuBTC easily penetrated the body wall of the JPS larvae and was transmitted to tissue cells though contact and diffusion. Furthermore, AM@CuBTC can effectively enhance the cytotoxicity and utilization of AM, which provides valuable research value for the application of typical plant-derived nerve agents in the prevention and control of forestry pests. AM@CuBTC as an environmentally friendly nanopesticide can efficiently deliver AM to the larval intestines where it is absorbed by the larvae. AM@CuBTC can be transmitted to the epidemic wood and dead wood at a low concentration (10 mg/L).

Total Phenolic Contents and Anti-lipooxygenase Activity of the Methanolic Extracts from <i>Durio zibethinus</i> Murr

Durio zibethinus parts (leaves, stem bark, and root) used to treat malaria fever, vermifuge, diabetes, jaundice, inflammation, and oxidative stress management prompted the investigation of their total phenolic contents and anti-lipooxygenase activities. The total phenolic concentration of D. zibethinus parts was determined spectrophotometrically after collection and extraction. The anti-inflammatory activity was estimated using a lipooxygenase assay. Total phenolic content measured in gallic acid equivalent (GAE) gave the highest levels of 6.88 ± 1.54, 23.32 ± 1.73, and 29.00 ± 3.43 mg GAE/g sample weight leaves stem bark, and root extracts, respectively. The plant extracts showed lower anti- lipooxygenase activity in leaves (IC50 µg/mL- 1.464) and stem bark (IC50 µg/mL- 1.203), but had significant activity in root (IC50 µg/mL- 1.400) compared to standard indomethacin (IC50 µg/mL- 1.660). The plant extract's declining order of anti- lipooxygenase activity follows the same trend with the phenolic contents, indicating that the extract's magnitude of anti- lipooxygenase activity is comparable with the quantity of phenolic compounds present in the extracts. Hence, the D. zibethinus extracts are a potential candidate for a plant-derived anti-inflammatory agent.

Combination of Sanguisorbigenin and Conventional Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus: Inhibition of Biofilm Formation and Alteration of Cell Membrane Permeability.

Methicillin-resistant Staphylococcus aureus (MRSA) infection is challenging to eradicate because of antibiotic resistance and biofilm formation. Novel antimicrobial agents and alternative therapies are urgently needed. This study aimed to evaluate the synergy of sanguisorbigenin (SGB) isolated from Sanguisorba officinalis L. with six conventional antibiotics to achieve broad-spectrum antibacterial action and prevent the development of resistance. A checkerboard dilution test and time-to-kill curve assay were used to determine the synergistic effect of SGB combined with antibiotics against MRSA. SGB showed significant synergy with antibiotics and reduced the minimum inhibitory concentration of antibiotics by 2–16-fold. Biofilm inhibition assay, quantitative RT-PCR, crystal violet absorption, and transmission electron microscopy were performed to evaluate the synergy mechanism. The results indicated that SGB could inhibit biofilm formation and alter cell membrane permeability in MRSA. In addition, SGB was found to exhibit quite low cytotoxicity and hemolysis. The discovery of the superiority of SGB suggests that SGB may be an antibiotic adjuvant for use in combination therapy and as a plant-derived antibacterial agent targeting biofilms.

Sustainable nano-pesticide platform based on Pyrethrins II for prevention and control Monochamus alternatus

BackgroundPine wilt disease as a devastating forest disaster result from Bursaphelenchus xylophilus that spread by stem-borers Monochamus alternatus feeding on pine leaves, which has brought inestimable economic losses to the world's forestry due to lack of effective prevention and control measures. In this paper, we put forward a proposal for utilizing nanoHKUST-1 to encapusulate the Pyrethrins II that a nerve agent extracted from plant to control M. alternatus, including toxicity mechanism research, traceable biopesticide monitoring, and environment assessment for the first time. The highly biocompatible nanoHKUST-1 can solve the problems of poor water solubility, easy degradation and low control efficiency of Pyrethrins II.ResultsThe results illustrated the biopesticide loading efficiency of PthII@HKUST-1 reached 85% and the cumulative release of pH-dependent PthII@HKUST-1 was up to 15 days (90%), and also effectively avoid photodegradation (pH 7.0, retention 60.9%). 50 nm PthII@HKUST-1 made it easily penetrate the body wall of MA larvae and transmit to tissue cells through contact and diffusion. Moreover, PthII@HKUST-1 can effectively enhance the cytotoxicity and utilization of Pyrethrins II, which will provide valuable research value for the application of typical plant-derived nerve agents in the prevention and control of forestry pests. PthII@HKUST-1 as an environmentally friendly nano-pesticide can efficiently deliver Pyrethrins II to the larval intestines and absorbed by the larvae. PthII@HKUST-1 could also be transmitted to the epidemic wood and dead wood at a low concentration (10 mg/L).ConclusionHere we speculate that nanoHKUST-1 will bring new opportunity to research biopesticide inhibition mechanism of different agricultural and forestry pests, which will break through the existing research limitations on development, utilization and traceable monitoring of biopesticide, especially for the study of targeting specific proteins.Graphical

Cytotoxic effects of phloridzin

Aim: Cancer has been the most lethal disease globally, notably in the last century. Each type of cancer and the response of cancer cells to treatment is unique motivates scientists to conduct new studies every day. Due to accumulating mutations, existing drugs, particularly those intended to treat cancer, are insufficient in treating cancer. This creates a strong need for research to discover new molecules or increase drug efficacy in cancer treatment. Regarding the development of alternative anticancer drugs, plant-derived agents stand out for their correlation with cancer. The flavonoids included in the fruits and vegetables we eat daily are thought to play a role in cancer prevention and provide new therapeutic options. Flavonoids are thermostable polyphenolic compounds commonly found in nature. In our study, the Phloridzin flavonoid obtained from apples, a fruit that we consume a lot in our daily life, has been tested on different cell lines such as MDAMB231, MCF-7, 293T, 22RV1, U87, A549, and it has been tested whether it has a cytotoxic effect. We observed that Phloridzin exhibited selective cytotoxicity in these cancer cells. We hope that this research will shed light on further research on the mechanism of death of Phloridzin and its use as an alternative to cancer treatment.Methods: -Results: -Conclusion: -

Proteomic analyses revealed the antibacterial mechanism of Aronia melanocarpa isolated anthocyanins against Escherichia coli O157: H7

Aronia melanocarpa anthocyanins (AMAs), as a natural plant extract, can control pathogens and are attracting increasing attention. However, at the proteomic level, the antibacterial mechanism of AMAs against Escherichia coli O157: H7 remains unclear. In this study, the tandem mass tag (TMT) quantitative proteomics was used to elucidate the potential antibacterial mechanisms of AMAs against E. coli O157: H7 cells. Ultrastructural observation and reactive oxygen species (ROS) levels detection showed that AMAs destroyed the integrity of E. coli O157: H7 cell membrane, led to the aggregation of contents and caused the increase of intracellular ROS level. TMT-based proteomic analysis suggested that AMAs can enter cells through mechanosensitive channels and inhibit the activity of heat shock proteins; disturb the metabolism of carbohydrates, amino acids and lipids in cells. The results of this study provide a reference for the further development of plant-derived antimicrobial agents.

Plant-Derived Natural Compounds for the Treatment of Amyotrophic Lateral Sclerosis: An Update.

BackgroundAmyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) that typically causes death within 3-5 years after diagnosis. Regardless of the substantial scientific knowledge accrued more than a century ago, truly effective therapeutic strategies remain distant. Various conventional drugs are being used but are having several adverse effects. Objective/AimThe current study aims to thoroughly review plant-derived compounds with well-defined ALS activities and their structure-activity relationships. Moreover, the review also focuses on complex genetics, clinical trials, and the use of natural products that might decrypt the future and novel therapeutics in ALS. MethodsThe collection of data for the compilation of this review work was searched in PubMed Scopus, Google Scholar, and Science Direct. ResultsResults showed that phytochemicals like-Ginkgolides, Protopanaxatriol, Genistein, epigallocatechingallate, resveratrol, cassoside, and others possess Amyotrophic lateral sclerosis (ALS) activity by various mechanisms. ConclusionThese plant-derived compounds may be considered as supplements for conventional (ALS). Moreover, further preclinical and clinical studies are required to understand the structure-activity relationships, metabolism, absorption, and mechanisms of plant-derived natural agents.

Current Advancements of Plant-Derived Agents for Triple-Negative Breast Cancer Therapy through Deregulating Cancer Cell Functions and Reprogramming Tumor Microenvironment.

Triple-negative breast cancer (TNBC) is defined based on the absence of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors. Currently, chemotherapy is the major therapeutic approach for TNBC patients; however, poor prognosis after a standard chemotherapy regimen is still commonplace due to drug resistance. Abnormal tumor metabolism and infiltrated immune or stromal cells in the tumor microenvironment (TME) may orchestrate mammary tumor growth and metastasis or give rise to new subsets of cancer cells resistant to drug treatment. The immunosuppressive mechanisms established in the TME make cancer cell clones invulnerable to immune recognition and killing, and turn immune cells into tumor-supporting cells, hence allowing cancer growth and dissemination. Phytochemicals with the potential to change the tumor metabolism or reprogram the TME may provide opportunities to suppress cancer metastasis and/or overcome chemoresistance. Furthermore, phytochemical intervention that reprograms the TME away from favoring immunoevasion and instead towards immunosurveillance may prevent TNBC metastasis and help improve the efficacy of combination therapies as phyto-adjuvants to combat drug-resistant TNBC. In this review, we summarize current findings on selected bioactive plant-derived natural products in preclinical mouse models and/or clinical trials with focus on their immunomodulatory mechanisms in the TME and their roles in regulating tumor metabolism for TNBC prevention or therapy.

Chemical Composition of Gossypium herbaceum linn and its Antioxidant, Antibacterial, Cytotoxic and Antimalarial Activities

Gossypium herbaceum ( G. herbaceum ), a plant commonly found in the wild in Nigeria, is said to possess some therapeutic activities. However, there is a dearth of information on its chemical constituents. Also, there is a need to investigate its therapeutic activities. To investigate the qualitative and quantitative phytochemical components of the leaf extracts of G. herbaceum , as well as its antioxidant, antimalarial and cytotoxic activity. Gas chromatography-mass spectrometry (GC-MS) analysis was used to determine the components of ethanol and hexane extracts of G. herbaceum leaf while 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide assays were used to determine the antioxidant potential. Malaria parasites viability was examined using parasite lactate dehydrogenase (pLDH) technique and HeLa cell was used for the cytotoxicity evaluation. Bioactive compounds identified in ethanol and hexane extracts of G. herbaceum were 37 and 30 kinds, respectively, with major components as linoleic acid (36.10% and 33.82%), vitamin E (7.15% and 5.98%) and caryophyllene (4.21% and 5.08%). It also has tannins, saponins, alkaloids, flavonoids steroids, phenols and terpenoids. In antibacterial test, significant inhibitory potentials against multidrug-resistant bacteria strains were present. In vitro antioxidant potentials (IC 50 ) of ethanol and hexane extracts were 3.33 and 4.12 µg/mL for DPPH assays, and 3.87 and 5.00 µg/mL for nitric oxide assays, respectively. Antiplasmodial activities (IC 50 ) were 9.99 and 9.76 µg/mL for ethanol and hexane extracts, respectively. G. herbaceum leaf may provide novel plant-derived therapeutic agents, effective in treating infectious diseases arising from multiple drug-resistant bacteria and a target in the management of oxidative stress.

Various Plants and Bioactive Constituents for Pigmentation Control: A Review

Hyperpigmentation disorders caused by excessive melanin synthesis may significantly affect the psychosocial aspect of an individual. Being the current gold standard used for the treatment of hyperpigmentation disorders, hydroquinone is associated with several adverse effects including skin irritation, contact dermatitis, mutagenic to mammalian cells, cytotoxic to melanocytes as well as exogenous ochronosis in darker-complexioned individuals. Botanically derived agents have received increased attention in treating hyperpigmentation as they are perceived to be milder, safer, healthier and more cost-effective. Several herbs, plant extracts and phytochemicals with multitude mechanisms of action have been reported to be effective depigmenting agents with milder side effects. Some of the agents were studied in combination and their hypopigmentation effects may be resulting from synergistic effects of the various components. Mechanisms involved in depigmentation include tyrosinase inhibition, inhibition of α-melanocyte-stimulating hormone-induced melanogenesis and antioxidant properties. Use of plant-derived agents for the treatment of hyperpigmentation disorders is promising with the need for more rigorous clinical studies to support the use of these agents. This review summarizes the use of various plants and bioactive constituents and their effectiveness in the control of pigmentation.

Antibacterial prophylaxis and molecular docking studies of ketone and ester compounds isolated from Cyperus rotundus L. against Aeromonas veronii

Microbial infection outbreaks and the indiscriminate use of therapeutants, and other chemicals are causing an inevitable economic loss in the aquaculture industry. There is an ample research on plant-derived antimicrobial agents that can prevail over microbial resistance. The inflorescence of an invasive aquatic weed, Cyperus rotundus, was examined for its antibacterial properties against Aeromonas veronii in this study. The minimum inhibitory concentration (MIC) of lead compounds isolated from an antioxidant-rich purified methanol fraction was 31.25 µg/ml against the fish pathogen. Pre-feeding compound-based feed to experimentally challenged catfish, Pangasianodon hypophthalmus, resulted in a cumulative survival probability of 85% against A. veronii infection, compared to 10% in untreated challenged fish. Curative outcomes were also obtained from haematological and histopathological investigations. Compared to the conventional antibiotic, Oxytetracycline (−259.95 kcal/mol), the isolated ketone compound, 2-tert-Butyl-9, 10-anthraquinone (−267.14 kcal/mol), exhibited the most favourable docking with aerolysin. This study is the first to report on Cyperus inflorescence's prophylactic antibacterial activity against one of the most prevalent fish pathogens.

Evaluation of the Membrane Damage Mechanism of Chlorogenic Acid against Yersinia enterocolitica and Enterobacter sakazakii and Its Application in the Preservation of Raw Pork and Skim Milk.

Plant-derived antimicrobial agents have adequate antimicrobial effects on food-borne pathogens, which can be used as food preservatives. The purpose of this study was to evaluate the antibacterial mechanism of chlorogenic acid (CA) against Yersinia enterocolitica and Enterobacter sakazakii. The minimum inhibitory concentration (MIC) of CA was determined by employing the broth microdilution method. Then, the cell function and morphological changes of Y. enterocolitica and E. sakazakii treated with CA were characterized. Finally, the growth inhibition models of Y. enterocolitica in raw pork and E. sakazakii in skim milk were constructed through the response surface methodology. The results demonstrated that CA has a satisfactory inhibitory effect against Y. enterocolitica and E. sakazakii with a MIC of 2.5 mg/mL. In addition, CA inhibited the growth of Y. enterocolitica and E. sakazakii via cell membrane damage, such as depolarization of the cell membrane, reduction in intracellular adenosine triphosphate (ATP) and pH levels, and destruction of cell morphology. Moreover, CA reduced two log cycles of Y. enterocolitica in raw pork and E. sakazakii in skim milk at a certain temperature. According to the corresponding findings, CA has the potential to be developed as an effective preservative to control Y. enterocolitica and E. sakazakii-associated foodborne diseases.

Issue Highlights

BioFactorsVolume 47, Issue 6 p. 884-884 ISSUE HIGHLIGHTSFree Access Issue Highlights First published: 11 December 2021 https://doi.org/10.1002/biof.1657AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Targeting tumor microenvironment by curcumin Xiao Fu, Yingni He, Mu Li, Zezhi Huang and Masoud Najafi To achieve the appropriate therapeutic response, we must kill cancer cells and suppress the release of immunosuppressive molecules. The balance between anti-tumor immunity and immunosuppressive cells, such as regulatory T cells, cancer-associated fibroblasts, tumor-associated macrophages, and myeloid-derived suppressor cells, plays a key role in the suppression or promotion of cancer cells. Curcumin is a plant-derived agent that has shown interesting properties for cancer therapy. It has shown that not only directly inhibit the growth of cancer cells but can also modulate the growth and activity of immunosuppressant and tumor-promoting cells. In this review, we explain how curcumin modulates interactions within TME in favor of tumor treatment. 914 Biological effects of ginger and its bioactive components in cardiovascular disease Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari and Amirhossein Sahebkar Inflammation and oxidative stress play critical roles in progression of cardiovascular disease. The anti-inflammatory and antioxidant properties of ginger (the rhizome of Zingiber officinale) and its bioactive components have been confirmed in many studies. Ginger blocks pro-inflammatory cytokines and the activation of the immune system and suppresses the activity of oxidative molecules. Ginger has been shown to have potent inhibitory effects against NF-κB; signal transducer and activator of transcription; NOD-, LRR-, and pyrin domain-containing proteins; toll-like receptors; MAPK; and mTOR signaling pathways. We summarize the biochemical pathologies underpinning a variety of cardiovascular diseases and the effects of ginger and its bioactive components, including 6-shogaol, 6-gingerol, and 10-dehydrogingerdione. 933 Therapeutic studies and biological properties of Teucrium polium Golgi stress response Fatma Rahmouni, Mongi Saoudi and Tarek Rebai Teucrium polium has been used in traditional medicine as antifungal, antipyretic, antispasmodic, and antibacterial. The effects of this plant have been investigated in kidney, liver, and brain. Its antidiabetic, antimicrobial, antioxidant, and anticancer effects have been introduced. Polyphenolic compounds, flavonoids, monoterpenes, alkanoides, and essential oils were identified. Several studies revealed that this plant has a hypoglycemic effect and can help to control blood sugar. In addition, T. polium has secondary effects on different organs, namely liver, kidney and at high doses this plant becomes toxic. In conclusion, this review investigates many pharmacological properties and side effects of T. polium. 952 Biological and pharmacological activities of noscapine Fahimeh Nourbakhsh and Vahid Reza Askari With few side effects and amazing capabilities, noscapine can be considered different from other opioids-like structure compounds. Since 1930, extensive studies have been conducted in the field of pharmacological treatments for malaria to control cough and cancer treatment. Furthermore, recent studies have shown that noscapine and some analogues, like 9-bromonoscapine, amino noscapine, and 9-nitronoscapine, can be used to treat polycystic ovaries syndrome, stroke, and other diseases. Given the numerous results presented in this field and the role of different receptors in the therapeutic effects of noscapine, we review the properties, therapeutic effects, and the role of receptors in the treatment of noscapine. 975 REFERENCES 1Xiao Fu, Yingni He, Mu Li, Zezhi Huang and Masoud Najafi. Targeting tumor microenvironment by curcumin. BioFactors. 2021; 47: 914– 932. Wiley Online LibraryGoogle Scholar 2Nazanin Momeni Roudsari, Naser-Aldin Lashgari, Saeideh Momtaz, Basil Roufogalis, Amir Hossein Abdolghaffari and Amirhossein Sahebkar. BioFactors. 2021; 47: 933– 951. Google Scholar 3Fatma Rahmouni, Mongi Saoudi and Tarek Rebai. Therapeutic studies and biological properties of Teucrium polium Golgi stress response. BioFactors. 2021; 47: 952– 963. Wiley Online LibraryGoogle Scholar 4Fahimeh Nourbakhsh and Vahid Reza Askari. Biological and pharmacological activities of noscapine. BioFactors. 2021; 47: 975– 991. Wiley Online LibraryGoogle Scholar Volume47, Issue6November/December 2021Pages 884-884 ReferencesRelatedInformation

Effects of Essential Oils and Selected Compounds from Lamiaceae Family as Adjutants on the Treatment of Subjects with Periodontitis and Cardiovascular Risk

Essential oils from different plant species were found to contain different compounds exhibiting anti-inflammatory effects with the potential to be a valid alternative to conventional chemotherapy that is limited in long-term use due to its serious side effects. Generally, the first mechanism by which an organism counteracts injurious stimuli is inflammation, which is considered a part of the innate immune system. Periodontitis is an infectious and inflammatory disease caused by a dysbiosis in the subgingival microbiome that triggers an exacerbated immune response of the host. The immune–inflammatory component leads to the destruction of gingival and alveolar bone tissue. The main anti-inflammation strategies negatively modulate the inflammatory pathways and the involvement of inflammatory mediators by interfering with the gene’s expression or on the activity of some enzymes and so affecting the release of proinflammatory cytokines. These effects are a possible target from an effective and safe approach, suing plant-derived anti-inflammatory agents. The aim of the present review is to summarize the current evidence about the effects of essentials oils from derived from plants of the Lamiaceae family as complementary agents for the treatment of subjects with periodontitis and their possible effect on the cardiovascular risk of these patients.