This article presents a sapphire-based Fabry–Perot acoustic sensor with potential for application in harsh environment acoustic sensing. The key component of the sensor is a thin sapphire diaphragm with a diameter of 20 mm and thickness down to 10 proposed Au–Au bonding-associated lapping and polishing technique. Microfabrication characterizations have corroborated the availability of realizing wafer-class thin sapphire diaphragm fabrication by employing the Au–Au bonding-associated lapping and polishing technique, and the diaphragm can be then easily transferred and assembled as a sensor. The strategy for optimizing the stripping phenomenon during lapping is also proposed. Acoustic calibration experiment through a plane wave tube indicates the sensitivity of 13.58 mV/Pa at 10 kHz and the frequency response range of 100250 kHz. The temperature tolerance experiment through the muffle furnace shows that no structural damage or optical spectrum invalidity occurs even if the environmental temperature reaches 800°, which indicates a high working temperature of the sensor up to 80°. Major findings and future application directions of this article are concluded as: 1) realization of an innovative sapphire-based Fabry–Perot acoustic sensor that shows significant potential in applications of numerous key industrial domains, such as aerospace engineering, and 2) a novel approach for achieving wafer-class sapphire ultrathin diaphragm fabrication, which might offer innovative methods for the optimization of sapphire-based harsh environment sensors and give reference to the sapphire lapping process as demanded in the gallium nitride (GaN)-based light-emitting diodes (LED) industry.