Urbanization is occurring at an unprecedented rate in developing countries like Ethiopia, especially with the rapid growth of industrialization. However, this urbanization and industrial development surge puts immense pressure on preparing and implementing city spatial plans. Urban spatial planning plays a crucial role in shaping the development of cities, aiming to create livable and sustainable urban development. The plan-making process and its subsequent implementation often encounter challenges that hinder the realization of planned objectives. Galan and Dukem, cities near Addis Ababa’s capital, have seen substantial industrial investment in recent decades. This article explores the challenges associated with urban spatial planning and industrial development while proposing alternative approaches. The paper relies on information gathered from primary and secondary sources, including expert surveys and key informants’ interviews. The research highlights that industrial developments have led to significant and uncontrolled changes in urban land use and urbanization in the study areas. Due to the lack of clear planning guidelines and institutional capacity, the study cities are experiencing haphazard development without effective urban spatial plans. Proximity to Addis Ababa has driven the urbanization process through increased investments. The article contends that effective management of urbanization and industrialization can create enjoyable living conditions and foster job growth. Macroeconomic policies, including industrial policies, should pay attention to spatial elements and prevent policy-making processes that are “space-blind”. This, however, requires clairvoyance and a high level of expertise, integrating inputs from advocacy planning and community participation to bridge gaps and ensure effective urban spatial plans and industrialization processes.