Dandruff Research Articles

SEBORRHEIC DERMATITIS, SCOPING REVIEW

Introduction: Seborrheic dermatitis (SD) is a common skin disease, where its signs and symptoms may differ according to skin color, associated medical conditions, environmental factors, and vehicle preference. Seborrheic dermatitis is a common skin condition in infants, adolescents and adults, characterized by scaling, erythema and itching, especially on the scalp, face, chest, back, armpits and groin. Objective: to detail the current information related to seborrheic dermatitis, etiology, epidemiology, pathophysiology, histopathology, clinical presentation, evaluation, differential diagnosis, treatment and prognosis. Methodology: a total of 29 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 23 bibliographies were used because the other articles were not relevant for this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: sebopsoriasis, seborrheic dermatitis, seborrheic eczema, dandruff and pityriasis capitis. Results: The most relevant results indicate that seborrheic dermatitis has a significant global prevalence, affecting up to 5% of the population, with a higher incidence in individuals with HIV-AIDS. Its pathogenesis has been identified as involving a combination of factors, including Malassezia spp. colonization of the skin, alteration of the cutaneous microbiota and a deregulated immune response. The most effective treatments are topical, particularly antifungal agents such as ketoconazole and low potency corticosteroids, although treatment should be tailored to the individual characteristics of each patient. Despite being a chronic disease in many cases, early diagnosis and proper management allow control of symptoms and improve the quality of life of patients. Conclusions: Seborrheic dermatitis is a common skin disease, with significant prevalence in various ages and groups, especially in people with HIV-AIDS. Its pathogenesis involves factors such as colonization by Malassezia spp, alterations in the cutaneous microbiota and immune dysregulation. Although it may be self-limiting in some cases, in others it presents a chronic course with relapses. The most effective treatment includes topical antifungal and anti-inflammatory agents, adapted to the severity and location of the lesions. Early diagnosis and appropriate treatment are key to control symptoms and improve the quality of life of patients. KEY WORDS: dermatitis, seborrheic, eczema, skin.

Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management

Malassezia furfur is the primary etiological agent of dandruff (Pityriasis capitis). Although herbal shampoos are preferred for their natural, mild ingredients over synthetic counterparts, they are often perceived as less effective in managing flaky scalp conditions or furfuration causing dandruff. The study compares the antifungal efficacy of herbal and synthetic shampoos against M. furfur. Seven shampoos including herbal (HS_Adv, HS_M&P, HS_Aloe), synthetic (SYN_01, SYN_02, SYN_03) and an antifungal shampoo containing ketoconazole (KETO) were employed in the study. Experiments were designed to stimulate real-world conditions, utilizing disc-diffusion assay, 3-minute shampoo contact at mild dilutions (1% and 5%), recurrent 3-minute shampoo contact every 24 h with intermittent recovery. Both disc diffusion and 3-minute shampoo contact demonstrated that all shampoos were effectively inhibiting the viability of M. furfur. However, a single 3-minute shampoo contact followed by a prolonged recovery of 72 h revealed SYN_01 and KETO with maximal antifungal action. In contrast, herbal shampoos were as effective as synthetic options when M. furfur was subjected to 3-minute shampoo contact every 24 h with intermittent recovery. Comprehensive ingredient analysis revealed the robust antifungal activity in SYN_01 was probably because of the presence of various surfactants, allergens and a potent synthetic antifungal agent, Piroctone olamine. This study experimentally demonstrates that herbal shampoos are as effective as synthetic options in managing M. furfur-induced dandruff when applied consistently. The findings highlight the importance of regular scalp cleansing for dandruff management and provide valuable insights into the antifungal potential of both herbal and synthetic formulations.

Mexican Mint (Coleus amboinicus) Emulgel: Natural Solution for Antidandruff Hair Care

Today, the world is developing more and more in all sectors at a faster pace. But with all these developments, people are more prone to falling ill due to factors such as pollution, unhealthy lifestyles, busy work schedules, etc. Nowadays, even children suffer from the issue of dandruff and scalp infections which in later teenage years leads to unhealthy scalp and hair fall problems. Dandruff is a common scalp condition that affects individuals of all ages. It not only causes discomfort but also undermines hair health and aesthetics. Although scalp disorders are not among those that cause severe physical illness or morbidity yet are of great social concern. Scalp and hair conditions have more of a psychological impact on societies. Even minor changes in hair like graying of hair, affects the self-confidence and self-esteem of an individual. There are many types of medications and formulations to treat hair dandruff issues, one of which includes a novel drug delivery system such as “Emulgel” in the form of a mask. The anti-dandruff hair mask offers multiple benefits, including reduction in scalp inflammation and effective management of hair dandruff problems. Furthermore, it rejuvenates the scalp and nourishes hair follicles due to its natural vitamins and nutrient content. Keywords: Dandruff, Pityriasis capitis, Seborrheic dermatitis, Mexican mint, Herbal hair mask, Hair mask

A Conceptual Recapture of Darunaka and its Relevance in-Present Era

Introduction: Ayurveda describes local minor diseases in detail along with systemic diseases. Cosmetic diseases are those that impact a person's emotional, psychological, and social well-being. In Ayurveda, Darunaka, a cosmetic ailment, is referred to as either Kapalgat Roga or Kshudra Roga. Darunaka is a safe substance that doesn't hurt, but it might cause psychological tension and low self-esteem. Everyone is highly aware of the importance of hair care, and according to Ayurveda, Darunaka is one of the main causes of hair loss. Darunaka is the Ayurvedic term that most closely correlates seborrhoeic dermatitis and dandruff (pityriasis capitis). Few explorations have been conducted regarding above, but no one has covered all aspects comprehensively thus this paper aim to collect and comprehensive review information available regarding about Darunaka and to understand its relevance in present era and preventive care. Methodology: This review is in a narrative format and done from literature and publications relevant to Darunaka Vyadhi and dandruff. Results: According to Vagbhata the prognosis of Darunaka is included in Sadhya stage. This literature review includes pathogenesis, contributing factors, management of Darunaka as per Ayurveda. These basic principles of the Vyadhi are still applicable and it improves the quality of life of the patient. There's a good chance that Darunaka's Ayurvedic care will unravel the disease's pathophysiology. Discussion: The discussion is mainly based on conceptual part and the effect is made to draw a final conclusion.

Prevalence of skin diseases among hostellers attending the tertiary care hospital

Background: Skin diseases are more common but are mostly non-fatal and chronic. Dermatological conditions account for a significant proportion of the global burden of diseases. Aims and Objectives: The study aimed to determine the prevalence of skin diseases among hostellers, determine the causative factors, and describe the prevention. Materials and Methods: This cross-sectional study was conducted for 2 months in the outpatient Department of Dermatology, Government Medical College, Pudukottai, on 507 hostellers. The study subjects were examined and diagnosed by the dermatologist. Questions such as exposure to sunlight, usage of sunscreen, frequency of head baths, and junk food consumption were asked and recorded in a case study form by the principal investigator. Results: Pityriasis capitis was the most prevalent skin disease among 507 participants, followed by acne vulgaris (54.83%) and pediculosis capitis (25.64%). Pityriasis capitis is more common in men (56.17%), with higher chances in those with head baths (<3 times/week) and exposure to sunlight (28.08%). Acne vulgaris affects both males and females equally; face washing <3 times daily is associated with oil and sebum retention, while lack of sunscreen and junk food intake are linked. Periorbital melanosis is more prevalent in females (54.62%) and is linked to stress (66.39%). Sleep duration is also a factor, with 69.23% of girls having a history of cosmetic usage. Conclusion: Pityriasis capitis, acne vulgaris, pediculosis capitis, dermatophytosis, and periorbital melanosis are common skin diseases caused by sharing, sleep deprivation, stress, and poor hygiene. Proper hygiene, sleep patterns, and self-care can reduce skin disease incidence.

TAMPOO AS A NOVEL ANTIDANDRUFF FORMULATION

Pityriasis capitis commonly known as dandruff, is an un-inflamed or mildly inflamed form of seborrheic dermatitis and appears as bran-like scaly patches scattered within hair bearing areas of the scalp and which could result in scaly itchy skin of the scalp. The present research work was carried out to develop tampoo. Tampoo is a novel solid dosage antidandruff formulation loaded with ketoconazole, prepared by direct compression technique having ease of manufacturability, improved stability and which becomes shampoo after aqueous dispersion, the moment it comes in contact with water. The combination of elastic and plastic materials, viz gaur gum and dibasic calcium phosphate in appropriate proportions was used to compress poorly compressible sodium lauryl sulphate. Tapmoos were compressed using direct compression method and evaluated for effect of filler binder, foam booster and disintegrating agents. Based on the results obtained, it was found that formulation F6 containing surface active agent (sodium lauryl sulphate) and foam booster (gaur gum) imparts acceptable pharmaceutical properties.

The Relationship of Stress Level to the Incidence of Pityriasis Capitis (Dandruff) in Students at SMK Panca Karsa Sungai Pinyuh

Stress is a condition of disturbing the balance of organisms that involves physiological or psychological tension caused by internal or external factors. Stress is one of the factors that can trigger the incidence of Pityriasis capitis. The level of stress is closely related to the high activity of sebaceous glands which results in changes in temperature and humidity on the scalp. To know the relationship between stress level with the incidence of Pityriasis capitis (dandruff) among female student of Vocational and Pre-Professional High School Panca Karsa Sungai Pinyuh. Observational analytic research with approach design research type cross-sectional. A total of 50 people was involved in this experiment. Independent variable was stress level, and dependent variable was Pityriasis capitis (dandruff) incidence among female students at Vocational and Pre-Professional high school Panca Karsa Sungai Pinyuh. From 50 people, it was found that Pityriasis capitis occurred respondents with normal stress level about 42,9%. The results of the Kolmogorov-Smirnov comparative test showed a significance value of p = 0.591 (p> 0.05) indicating that there was no significant relationship between stress level and Pityriasis capitis (dandruff). There is no relationship between the level of stress with the incidence of Pityriasis Capitis (dandruff) among female students at Vocational and Pre-Professional high school Panca Karsa Sungai Pinyuh.

Dermatological disorders and dermatology-specific quality of life among secondary students in public and private schools in Kwara state, Nigeria

Introduction: Skin problems are very common and often affect people in very visible places leading to significant physical and psychological distress. Adolescents go through physiologic changes in their body during puberty with associated psychosocial changes. Having to live with skin disorders during these years can have life-long impact. This study aimed to describe the spectrum of skin disorders in adolescents attending secondary schools in Kwara state and evaluate the dermatology-specific quality of life of those affected by skin disorders.
 Objective: To describe the spectrum of skin disorders among adolescents in secondary schools and evaluate the impact of skin disorders on the dermatology-specific quality of life of those affected.
 Methods: This was a descriptive cross-sectional study. We examined 1000 students from 16 public and private secondary schools in Ilorin, Kwara state. Participant selection was done using a multi- staged stratified random sampling method. The impact on quality of life was evaluated with the Children’s Dermatology Life Quality Index (CDLQI) to determine their dermatology-specific Quality of life. Data obtained was analyzed with SPSS version 20 and was presented using tables and figures.
 Results: The prevalence of skin disease in the study population was 68.4%. The most common skin disorders in order of decreasing frequency were: acne, pityriasisversicolor, dermatophytoses (Including tinea capits, tinea corporis, tinea pedis, tinea unguium and tinea cruris), pityriasis capitis and traction alopecia. About three- quarters of those with skin disease reported an effect on their quality of life. The most frequent effect on Qol was attributed to the symptoms and feelings elicited by skin disease.
 Discussion: This study found a high prevalence of skin disease in adolescents with most of them reporting an effect on their quality of life resulting from their skin problem however this was mostly a mild effect.

A clinical study to assess the effect of Priyaladi lepa in Darunaka (Pityriasis capitis)

Background: Darunaka is one of the Shirah-kapalagata Roga (head and skull diseases) and Kshudra Roga (minor ailments), characterized by Kandu (itching), Rukshata (dryness), Twak-sphutana (scaling), and Kesha-chyuti (hair fall). The clinical features correlate to Pityriasis simplex capitis (dandruff), which is a common condition that causes itchy, scaly skin on the scalp with high prevalence in the general adult population. Ayurveda emphasizes various Lepa Kalpana (semisolid medicaments used for external application) for Darunaka; Priyaladi lepa is one among them. As there is ambiguity about successful dandruff treatment due to its severity and frequent relapses, it necessitates finding an effective and safe topical antidandruff agent. Aim: To assess the effect of Priyaladi lepa in the management of Darunaka. Materials and Methods: Study was intended as an open-label, nonrandomized, single-arm, interventional trial. Thirty subjects were treated with the application of Priyaladi lepa on the scalp weekly twice for consecutive 2 weeks. Results: Overall results showed a decline in the severity of symptoms such as itching, dryness of scalp, cracking, and scaling of scalp as assessed with a five-point Likert scale. Conclusion: Application of Priyaladi lepa on the scalp showed a highly significant effect in pacifying the symptoms of Darunaka, and a marked reduction in clinical symptoms was well appreciated with four applications. There were no topical and systemic adverse drug effects noted at the end of the study.

A cross sectional study on health status of adolescents in urban field practice area of tertiary care hospital in central India

Background: Adolescence is defined by WHO as the age group of 10-19 years. In India, adolescents (10-19 years) constitute about 21.4 percent of the population, comprising one fifth of the total population. Adolescents are apparently healthy people but they may also have various kinds of problems. If they are to reach adulthood in a healthy state, then it’s necessary to analyze the common health problems prevalent in this age-group so that targeted and concerted services could be provided to them. Objective of current study was to assess the health status of adolescents in urban field practice area of tertiary care hospital in Central India. Methods: A community based descriptive cross-sectional study was conducted in urban field practice area of Government Medical College and Hospital Nagpur. House to house survey was conducted among 330 adolescents out of which 214 (64.84%) were male and 116 (35.16%) were female. Results: In present study most common morbidity found was dandruff in 127 (38.48%) adolescents followed by acne vulgaris in 102 (30.90%). Anemia was present in 52 (15.75%) of study subjects. Out of 237 morbid study subject, 114 (48.10%) study subjects had single morbidity followed by 2 and 3 morbidities in 52 (21.94%) and 63 (26.59%) respectively. About 8 (3.37%) study subjects had more than 3 morbidities. Conclusions: The present study shows that adolescents experience various health problems. Predominant morbidities observed in study subjects are dandruff (pityriasis capitis), acne vulgaris, anaemia, dental carries.

STUDIES ON POLY HERBAL POWDER SHAMPOO FOR THE TREATMENT OF PEDICULOSIS CAPITIS AND PITYRIASIS CAPITIS INFESTATIONS

Objective: The main objective of this study was to the formulation containing polyherbal medicinal plants, which gives safety, and efficacy; rectify skin disease, scalp disorders and reducing the harmful effect from herbal anti-lice and dandruff shampoos for the treatment of Pediculosis capitis and Pityriasis capitis and to prevent hair fall. Methods: The formulation of herbal shampoo with various herbal ingredients were dried, milled, sieved (120#) and mixed in geometrical order and evaluated their physicochemical characteristics. Furthermore, particle characters, organoleptic properties, foaming index, skin irritation study, and Anti-lice activity were performed. Results: The prepared poly herbal powdered shampoo (PHPS) exhibits that was freely soluble, particle 20-25 μm size range and free-flowing powder. Lest moisture content (2.5%), ash value, acid value and reduced surface tension of liquid are referred as an ideal candidate for foaming, anti-lice potential with no skin irritations. Conclusion: Based on the evaluation parameters, the prepared powdered shampoo helps to remove hair grease, no hair fall and strengthen hair follicles. Preparation of PHPS formulation at laboratory scale and the compounding of several ingredients of herbal source have produced it possible to ensure safety, efficacy and secure highly effective PHPS.

A SYNOPTIC REVIEW ON PRIYALADI LEPA: AN AYURVEDIC TOPICAL FORMULATION FOR THE MANAGEMENT OF DARUNAKA (DANDRUFF)

Pityriasis capitis commonly known as Dandruff is a common skin disorder that mainly affects the scalp. It is one of the most common cosmetic problems. It is more likely a social stigma and affects the aesthetic value of a person. In Ayurveda, Acharya Sushruta mentions Darunaka (dandruff) under Kshudra kushta roga (minor skin ailment) and some other authors mention it as Shirah-Kapalagata roga (head and skull diseases). Symptoms of Darunaka are kandu (itching), Keshachyuti (hair fall), Twaksphutana (scaling) and rukshata (dryness). Darunaka can be closely co-related to Pityriasis capitis. Though not being a life-threatening disease, it is affecting almost half of the population from pre-pubertal age to old age of any gender with recurrence and frequent relapses. Ayurveda classics majorly emphasizes the bahya lepa upachaar (external paste application) as a line of treatment in Darunaka. Priyaladi lepa is one such formulation recommended in Sharangadhara Samhitha for Darunaka chikitsa, but not often applied in routine Ayurvedic practice. So, this study aims to appraise the pharmacological activity of the formulation Priyaladi lepa regarding its anti-dandruff efficacy. Rasapanchaka and Dosha karma (Ayurvedic Pharmacological attributes) of ingredients were compiled from Bhavaprakasha Nighantu and other Ayurvedic literature. Pharmacological actions were compiled from original research articles from Google Scholar, Research Gate and PubMed etc. research databases. A study on each ingredient of Priyaladi lepa collectively demonstrated anti-inflammatory, anti-fungal, anti-microbial, anti-pruritic, antioxidant and exfoliation effects. These pharmacological activities encourage further research and henceforth to utilize the same for the effective management of Darunaka (Dandruff).

Skin microbiome alterations in seborrheic dermatitis and dandruff: A systematic review.

Seborrheic dermatitis (SD) and dandruff (DF) are common chronic inflammatory skin diseases characterized by recurrent greasy scales, sometimes with erythema and itchiness. Although the exact pathophysiology of the disease is still unclear, current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Here, we conducted a systematic review to investigate the skin microbiome alterations in patients with SD/DF. We searched Medline/PubMed, Embase and Web of Science for research studies published in English between 1January 2000 and 31 December 2020. A total of 12studies with 706 SD/DF samples and 379healthy samples were included in this study. The scalp and face were predominated by the fungi of Ascomycota and Basidiomycota and the bacteria of Actinobacteria and Firmicutes. In general, the included studies demonstrated an increased Malassezia restricta/Malassezia globosa ratio and a reduction in the Cutibaterium/Staphylococcus ratio in the setting of SD/DF. Staphylococcus was associated with epidermal barrier damage, including elevated levels of trans-epidermal water loss and pH, while Cutibacterium had a positive correlation with water content. Malassezia was also found to be related to an increased itching score and disease severity. Further studies focusing on the interactions between various microbes and the host and microbes can help us to better understand the pathogenesis of SD/DF.

A study on malassezia species causing superficial infections among patients attending a tertiary care hospital in Puducherry

Introduction: Malassezia are normal resident flora in humans and are opportunistic in nature. Superficial infections caused by Malassezia include pityriasis versicolor, pityriasis capitis (dandruff), seborrheic dermatitis and folliculitis. Though the manifestations due to Malassezia are trivial, chronicity and recurrence of lesions are associated with social embarrassment and decreased self-esteem. Aims and Objectives: The primary aim of the study was to detect the prevalence of Malassezia among superficial skin and scalp lesions. It also aims to compare Wood’s lamp examination, KOH mount examination and culture for the diagnosis of Malassezia and study the percentage of various species of Malassezia responsible for superficial infections of skin and scalp. Materials and Methods: One hundred samples collected from patients attending the Dermatology outpatient room with superficial infections of skin and scalp. Patients attending Dermatology outpatient room with complaints of hypopigmented / hyperpigmented / erythematous, scaly skin patches and patients attending Dermatology OP with complaints of itchy / non itchy scaly flakes of scalp (dandruff) were included in the study. Results: Among the 100 samples, 77% were Wood’s lamp positive, 64% were KOH positive and 59% yielded growth of Malassezia in culture. Overall prevalence of Malassezia in our study was 59%. In our study, M. globosa was the commonest species (57.62%) followed by M. furfur and M. sympodialis. Conclusion: Prevalence of Malassezia was 59% in our study. Wood’s lamp examination and KOH mount showed more positivity than culture. M. globosa was the most common species in the study. Wood’s lamp and KOH mount can be used for diagnosis of Malassezia in resource poor settings. But culture and speciation should be performed wherever possible to avoid treatment failure and recurrences. Keywords: Culture, Malassezia, Potassium hydroxide mount, Skin scrapings, Wood’s lamp.

Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach

Pityriasis capitis commonly known as dandruff is one of the most common and widely seen dermatological disease that affects majority of the world population. It is more than superficial flaking, as it leads to significant structural changes in the stratum corneum and inflammatory biomarkers. Various intrinsic and extrinsic factors, such as Malassezia yeast, host epidermal conditions, sebaceous secretion, and abnormal immune responses, are found to contribute to the pathogenesis. Regardless of wide research, detail understanding, and treatment modalities, it still remains to be a cause of concern due to its recurring nature. The objective of this study is to enhance the understanding of its wide causes, pathophysiology, current treatment, and future approach. The article also aims at evaluating various promising anti-dandruff agents that can be further researched to become the leads in anti-dandruff therapy. The article summarizes the current knowledge on dandruff and present new facts and evidences in order to spread awareness, create potential for new herbal treatment options, and effectively control the most commercially exploited scalp disorder.

Cutaneous disorders of adolescence among Nigerian secondary school students.

IntroductionA community-based, age-specific survey of skin disorders is usually necessary to characterize the true burden of skin disease among a given population and help to tailor health care personnel training and delivery towards the prevalent disorders in resource poor settings.MethodsThis was a descriptive cross-sectional study among adolescents attending secondary schools in Ilorin, Kwara State, Nigeria. A thousand and three hundred students were recruited from public and private secondary schools through a multi-staged stratified random sampling method. Information was obtained via a semi-structured questionnaire and all students underwent a physical examination. Data was analysed using SPSS version 20. Information generated was presented with tables and figures.ResultsThe prevalence of skin disease in the study was 66.5%. More females, mid-adolescents, students in senior class and those attending public schools had skin disorders. The most prevalent skin disease were: acne vulgaris, pityriasis versicolor, tinea capitis, pityriasis capitis and traction alopecia.ConclusionSkin conditions are highly prevalent among the adolescent population. Infective and inflammatory skin conditions appear to be more prevalent than other classes. Most times, only a few skin disorders account for the bulk of dermatoses affecting this age group. Adolescent skin healthcare should be subsidized because of the high prevalence of skin disorders in this age group.

Clinicoepidemiological Profile of Pityriasis Versicolor in a Tertiary Care Hospital in Kathmandu, Nepal

Pityriasis versicolor (PV) also known as Tinea versicolor is a benign, chronic superficial fungal infection of the skin caused by Malassezia furfur. It is characterized by dyspigmented macules with fine branny scales. The purpose of this study was to assess the epidemiological profile and clinical pattern of PV in a group of patients visiting a tertiary care centre of Nepal. A descriptive cross-sectional study was carried out including 150 patients diagnosed to have PV at the outpatient dermatology department of Nepal Medical College Teaching Hospital. Patients with the diagnosis of PV were included in the study. A detailed history was taken and it was followed by a thorough clinical examination. The findings of history and clinical examinations were documented in a predesigned proforma. Statistical Package for the Social Sciences (SPSS) version 16 was used to tabulate the data and analyze the results. There was a slight male preponderance with maximum patients of the age group 11 – 20 years. A majority of patients were students. Forty three (28.7%) patients had similar problem in close contacts and 42% had recurrent disease. Wearing of occlusive synthetic clothing was the commonest predisposing factor. Upper chest and upper back were the most involved sites. Hypopigmented macules were the commonest lesions in 72.7%. Coexisting seborrheic dermatitis (commonly pityriasis capitis ) was present in 44.67% of patients. Clinicoepidemiological profile of PV in our setting is similar to many studies done mostly in India. But few findings differ which indicates the need for further studies in Nepal especially from Terai regions where the prevalence is expected to be more.

The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin.

ObjectiveDry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases.MethodsThirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects). After 4 weeks of daily treatment with a pseudo-ceramide and eucalyptus extract-containing lotion, the skin symptoms had significantly improved in all patients with those skin diseases.ResultsSkin dryness, scaling, and erythema were significantly improved by treatment with the lotion. The moisture-retention ability of the scalp was significantly increased and itchiness, evaluated using a visual analog scale, decreased significantly. Accompanying those improvements was a significant improvement in the quality of life of the subjects, evaluated by the Skindex-16®.ConclusionFrom these results, we conclude that this pseudo-ceramide and eucalyptus extract-containing lotion effectively improved the dry and scaly conditions of the scalp as well as the quality of life of subjects with atopic dermatitis, seborrheic dermatitis, or pityriasis capitis.

DEVELOPMENT AND EVALUATION OF HAIR GEL FOR THE TREATMENT OF DANDRUFF

Dandruff is a very serious problem today; various treatments are available in the market but show temporary effect. An attempt has been made to formulate an antidandruff hair gel of carbopol 940 containing ketoconazole (Antidandruff drug) and Aloe vera (Natural antifungal agent), which are effective for number of hours as compared to other marketed hair oils. Hair gel increases the retaining time of drug and improve the effectiveness of antifungal agents. Aloe vera keep your hair moisturized, prevent from damage and drying. Aloe vera is used in formulation to reduce the dose of ketoconazole and also reduces the adverse and side effect of same.

ARNICA HYDROGEL: AN OIL REPLACEMENT FOR HAIR LOSS TREATMENT

Hair loss problems can affect physical and mental health of human and have particular significance during pregnancy, lactation and aging process. At present a number of oils and shampoos are available in the market to promote hair growth. Applying the medicated hair oils and shampooing the hairs daily reduces the patient compliance. Thus no therapy is giving satisfactory results to the hair loss. Aim of this work is to prepare non sticky, non greasy, quickly absorbable Arnica Hydrogel to stimulate hair. Arnica montana is widely used herbal and homeopathic medicine for hair growth stimulation and available as arnica oil and arnica shampoo. It rejuvenate scalp, stimulates the hair follicles by improving the blood flow and prevent premature hair fall. Arnica montana also have anti-inflammatory and anti dandruff properties which assist its hair growth property. Hydrogel have been emerged out as one of the most beneficial topical drug delivery system. It is three-dimensional cross-linked polymer network. Hydrophilic structure of which make them capable of holding the drug and water in its three dimentional network. These biomaterials can hold large quantity of water and swell. When swelled, they become soft & spongy and exhibit excellent biocompatibility. Arnica Hydrogel was prepared by incorporating ethanolic extract of Arnica montana in hydrogel at a particular step in order to prepare non greasy formulation. Hydrogel was optimized for the concentration of Carbopol 934. Different Hydrogel formulations were evaluated for their physical appearance, viscosity, pH, spreadability and stability.