Sediment deposition has a substantial effect on the hydraulic capacity of channels in urban drainage and sewer systems. In this sense, the self-cleaning concept has been extensively used in the construction of urban drainage and sewer systems. In this regard, the design of the sewer system heavily depends on the accurate forecasting of the particle Froude number (Fr). This study is conducted on experimental data sets collected from existing studies, including a wide range of dimensionless grain size of particles (Dgr), sediment median size (d), hydraulic radius (R), volumetric sediment concentration (Cv), and pipe friction factor (λ) for the condition of clear bed. We forecasted the particle Froude number using four different input combinations. We employed the Random Tree (RT) and Reduced Error Pruning Tree (REPT) methods as standalone methods, as well as Random Committee (RC) and Bagging (BA) methods as hybrid machine learning (ML) methods in particle Froude number forecasting. Hybrid machine learning methods demonstrate enhanced performance compared to both standalone machine learning methods and empirical equations. In the context of sewer system design under non-deposited bed conditions, there is a need to accurately forecast the particle Froude number, RC-RT (IA = 0.96, R = 0.928, MSE = 0.718, RRMSE = 0.197, NSE = 0.86, and PBias = −0.284) performed the best, followed by BA-RT, RC-REPT, BA-REPT, RT, and REPT. In our research, it was found that, in forecasting the particle Froude number under non-deposited bed conditions, Cv emerges as the most responsive input parameter among others.