The objective of this study is to elucidate the mechanism by which blockages occur in sewer pipes following the deposition of fat, oil, and grease (FOG) and suspended solids (SS). In this study, a simulated wastewater flow experiment was conducted to elucidate the mechanism of sewer pipe blockage using lauric acid as fatty acid and florisil to simulate FOG and SS blockages, respectively. Unplasticized polyvinyl chloride pipes (ϕ = 50 mm) with a flow speed of 2 L/min and 1% inclination were used in this experiment. In “Case L & F (lauric acid florisil),” the deposition of florisil and adhesion of solids increased at the bottom of the sewer pipe over a set period. After seven days, decreases in lauric acid concentration from 1000 to 57 mg/L and in Ca2+ concentration from 18 to 0.8 mg/L were observed. FOG deposits formed solids by the saponification of lauric acid and Ca2+ from tap water. In the simulated kitchen wastewater, either lauric acid or florisil exhibited solid deposition and adhesion. Based on these findings, the blockage mechanism was elucidated to confirm FOG deposition of and SS influenced by the combination of lauric acid, Ca2+, and florisil.