Purpose: Pulmonary rehabilitation consistently demonstrates effectiveness with respect to improving exercise capacity in patients with chronic obstructive pulmonary disease (COPD). While this body of literature is substantial, few studies have examined the effect of pulmonary rehabilitation on groups who are of advanced age (>70 years) and/or entirely female. Methods: Thirteen female subjects diagnosed with COPD were enrolled in an outpatient pulmonary rehabilitation program. The mean age was (mean ± SD) 79.0 ± 5.2 years. Subjects underwent a progressive exercise test on a treadmill prior to and following pulmonary rehabilitation. Subjects also were tracked for cardiac and/or pulmonary emergency events occurring during the rehabilitation sessions (CPR, defibrillation, intubation, etc). Results: The total and mean number of pulmonary rehabilitation sessions, respectively was 259 and 19.8 ± 5.3. A paired t-test revealed a significant improvement in peak metabolic equivalent (MET) level during the exercise test following rehabilitation (2.6 vs. 4.3 METs, p<0.001). No events warranting emergency intervention occurred. Conclusions: This study indicates aerobic exercise training may be safe and effective in elderly female patients with mild to moderate COPD. Analysis of this population is of particular importance given the prevalence of COPD with advanced age and recent trends suggesting a rise in the number of females being diagnosed as compared to men.