Skin Color Research Articles

Research of salt tolerance and body color of bester

The aim: establish the possibility of keeping and growing in sea water with a salinity of more than 18‰ of different age groups of bester on marine fish farms. To investigate the body coloration of the breeders and offspring of the Bester hybrid.Methods used: the research was carried out in 2004–2005 in the Republic of Korea according to standard methods used in fisheries research.Novelty: data were obtained on the transfer of juveniles and yearlings of Bester to the sea water with a salinity of 28–29‰. Research confirmed the fundamental possibility, as well as the prospects for rearing juvenile bester in freshwater recirculating systems with the subsequent transfer of fish to sea water. Various bester’s shades of skin color are described.Result: as a result, the average weights of bester juveniles were established to start the transition to salt water. Analysis of the data showed that yearlings switch to a high salinity of 23–24‰ with a survival rate of more than 73%, and juveniles with low survival rate after 18‰. Ten Bester lines were identified, differing in skin color and fin shape.Practical significance: the experiment already has practical results in the Republic of Korea. Having sufficient resources of salty waters (the Baltic, Black, Caspian and Azov Seas), Russia has prerequisites for the successful cultivation of sturgeon in sea water. The connection of the offspring’s body color and its mother has been established, as well as its diversity depending on the places where sturgeons are cultivating.

Effects of spironolactone on skin biophysical properties in women with acne treated with oral spironolactone.

Spironolactone (SPL) is an effective treatment for women acne, but other effects on skin biophysical properties remain to be investigated. The aim of the current study was to explore the effects of oral SPL used to treat women acne on skin biophysical properties, including hydration, transepidermal water loss (TEWL), skin surface lipid (SSL) levels, mechanical properties, color, pH, and pore size. Twenty-five Thai women with acne treated with oral SPL were followed for 6 months. Skin hydration, TEWL, SSL levels, mechanical properties, color, pH, and pore size of the forehead, chest, and inner arm were evaluated at baseline and 2, 4, and 6 months after treatment with oral SPL. Facial and upper back pore size were also assessed. Clinical outcomes were changes in these skin biophysical properties at each visit compared with baseline. Skin hydration, TEWL, SSL levels, color, pH, and pore size remained stable throughout the study. Facial skin parameters at 6 months demonstrated the following changes: hydration levels, 7.60 (95% confidence interval [CI], -59.74 to 74.94); TEWL, -2.36 (95% CI, -5.77 to 1.06); L* value, 0.51 (95% CI, -0.70 to 1.72); individual typology angle, 1.65 (95% CI -2.27 to 5.57); pH, 0.01 (95% CI -0.43 to 0.46); pore size, -0.24 (95% CI, -1.21 to 0.73); and SSL levels, 7.60 (95% CI -59.74 to 74.94). Improvement of facial mechanical properties was observed. R0 (indicating skin tightness) and R1 (indicating elasticity) showed significant decreases (-0.076 [95% CI, -0.141 to -0.010] and -0.016 [95% CI, -0.033 to -0.001]). R3 and R4 (representing tiring effects) were also improved (-0.091 [95% CI, -0.158 to -0.025] and -0.022 [95% CI, -0.044 to -0.001]). Parameters in the truncal and inner arm areas remained stable, except for skin elasticity and tiring effects, which exhibited a similar trend of improvement as the facial area. The changes were notable as early as 4 months. Oral SPL used for acne did not impair the skin barrier. Moreover, the skin mechanical properties were improved at 4 to 6 months.

Vitamin D Deficiency in Childhood: A Review

Vitamin D is primarily obtained through sun exposure and diet, but factors like dark skin tone, limited time outside, and poor dietary habits can contribute to low levels of this essential vitamin. Getting enough Vitamin D is really important for kids' health, but a lot of them don't get enough because they don't spend enough time in the sun, don't eat well, or have trouble absorbing it. Not having enough can cause weaker bones, more infections, long-term illnesses, and problems with the immune system. To avoid this, children need to spend more time in the sun, eat foods rich in Vitamin D, and maybe take some supplements as well. In summary, this review highlights the importance of addressing vitamin D deficiency in children for their overall health and well-being.

Dermoscopic features of the normal vermilion in skin of colour.

Dermoscopic features of the normal vermilion in skin of colour.

Impact of herbal treatments for Vitiligo disease

Vitiligo is a common skin disorder resulting from the breakdown of functional epidermal melanocytes. The global prevalence of vitiligo ranges from 0.5% to 2%, with higher rates reported in certain populations. Melanocytes, responsible for skin color, are destroyed in vitiligo condition leading to the appearance of smooth, white patches on the skin. The progression of vitiligo is influenced by various factors, including genetics, autoimmunity, psychosis, melanocyte self-destruction, trace element deficiency, oxidative stress, and other biochemical and environmental variables. Recent research has identified herbal plant extractions as potential agents for re-pigmentation and regeneration of normal skin color. Specific components of these herbal plants, such as furocoumarin, thymoquinone, flavonoids, curcuminoids, and glycyrrhizin, play crucial roles in promoting re-pigmentation. Combination therapies involving these herbal compounds have shown promise in increasing tyrosinase activity and reducing oxidative stress, which are two important aspects of vitiligo treatment. The review aims to comprehensively evaluate the efficacy of herbal plant therapies for melanocyte re-pigmentation in vitiligo patients. By analyzing the effectiveness of various herbal extracts and their active components, this study seeks to advance the understanding and potential application of herbal treatments for vitiligo. The findings from this review may contribute to the current knowledge on therapeutic options available for vitiligo patients.

Three-dimensional printing technology applied to the production of prosthesis: A systemic narrative review.

The purpose of this scoping review was to investigate the effects of 3-dimensional (3D)-printed prostheses. Articles published up to August 19, 2023, were searched in the PubMed, Cochrane Library, Embase, and Scopus databases. The search terms used were "3D printed prosthesis," "3D printed prostheses," "3D printed prosthe*," "3D printed artificial arm," "3D printed artificial leg," "3D printing prosthesis," "3D printing prostheses," "3D printing prosthe*," "3D printing artificial arm," and "3D printing artificial leg." This review included studies that applied 3D-printed prostheses to upper- or lower-limb amputees. Case reports, conference abstracts, presentations, reviews, and unidentified articles were excluded from the analysis. A total of 937 articles were identified, 11 of which were included after confirming eligibility through the title, abstract, and full text. The results indicated that the 3D-printed prostheses demonstrated the ability to substitute for the functions of impaired limbs, similar to conventional prostheses. Notably, the production cost and weight were reduced compared with those of conventional prostheses, increasing patient satisfaction. The use of 3D-printed prostheses is expected to gain prominence in future clinical practice. However, concerns regarding the durability of 3D-printed prostheses have increased among users. Therefore, there is an ongoing need to explore highly durable materials that can withstand the weight of the user without breaking easily. In addition, advancements are required in technologies that enable the depiction of various skin tones and the production of smaller-sized prostheses suitable for clothing.

Investigation on the influence of the skin tone on hyperspectral imaging for free flap surgery

Hyperspectral imaging (HSI) is a new emerging modality useful for the noncontact assessment of free flap perfusion. This measurement technique relies on the optical properties within the tissue. Since the optical properties of hemoglobin (Hb) and melanin overlap, the results of the perfusion assessment and other tissue-specific parameters are likely to be distorted by the melanin, especially at higher melanin concentrations. Many spectroscopic devices have been shown to struggle with a melanin related bias, which results in a clinical need to improve non-invasive perfusion assessment, especially for a more pigmented population. This study investigated the influence of skin tones on tissue indices measurements using HSI. In addition, other factors that might affect HSI, such as age, body mass index (BMI), sex or smoking habits, were also considered. Therefore, a prospective feasibility study was conducted, including 101 volunteers from whom tissue indices measurements were performed on 16 different body sites. Skin tone classification was performed using the Fitzpatrick skin type classification questionnaire, and the individual typology angle (ITA) acquired from the RGB images was calculated simultaneously with the measurements. Tissue indices provided by the used HSI-device were correlated to the possible influencing factors. The results show that a dark skin tone and, therefore, higher levels of pigmentation influence the HSI-derived tissue indices. In addition, possible physiological factors influencing the HSI-measurements were found. In conclusion, the HSI-based tissue indices can be used for perfusion assessment for people with lighter skin tone levels but show limitations in people with darker skin tones. Furthermore, it could be used for a more individual perfusion assessment if different physiological influencing factors are respected.

SLC40A1-related hemochromatosis associated with a p.Y333H mutation in mainland China: a pedigree report and literature review

BackgroundHaemochromatosis is a genetic disease characterized by the excessive deposition of iron in various tissues and organs, eventually results in organ damage including cirrhosis, diabetes, cardiomyopathy, etc. SLC40A1-related haemochromatosis is associated with gain-of-function mutations in the SLC40A1 gene, which encodes ferroportin. While sporadic reports of this condition exist in mainland China, the understanding of the phenotype and genetic pattern associated with the SLC40A1 p.Y333H mutation remains incomplete.Case presentationWe report a pedigree with heterozygous p.Y333H mutation in Chinese Han population. The proband is a 64-year-old man complaining of persistent abnormality of liver enzyme levels for 1 year, with a history of knee joint pain, diabetes and skin pigmentation. He displayed markedly elevated serum ferritin level and transferrin saturation. Magnetic resonance imaging showed iron deposition in the liver, spleen, and pancreas, along with cirrhosis and splenomegaly. Whole exome sequencing identified a heterozygous allelic variant c.997T > C (p.Y333H). Genetic screening of family members identified four first-degree relatives and three second-degree relatives having the same mutation. Additional cases with this mutation from two published studies were included. Among the probands and screened relatives, all eight males aged over 30 y had ferritin level > 1000 µg/L, transferrin saturation > 90%. Four patients with organ damage in the present study received therapeutic phlebotomy, alleviating clinical symptoms and improving in transferrin saturation and serum ferritin.ConclusionsThis study reports the largest pedigree with heterozygous SLC40A1 p.Y333H mutation in the Chinese population to date. In Chinese families, males over 30 years old with hemochromatosis due to SLC40A1 p.Y333H mutation exhibit severe iron overload phenotypes.

Phenotypic characterization and culinary quality of cassava ethnovarieties cultivated in northern Mato Grosso, Brazil

Cassava (Manihot esculenta Crantz) has great importance as a food and serves as a raw material for various industrial products. The aim of this study was to evaluate phenotypic and culinary characteristics of the roots of 15 ethnovarieties of cassava sampled in northern Mato Grosso. The evaluated characteristics included root epidermis texture, skin color, cortex color and root pulp color before and after cooking, ease of removal of the skin and cortex, cooking time and aspects of the cooked mass. The ethnovarieties presented phenotypic diversity for the characteristics evaluated in their roots. The cooking time of cassava ethnovarieties cooked in a conventional pan ranged from 17 to 35 minutes. However, when the cooking of the ethnovarieties occurred in a pressure cooker, all were cooked within 10 minutes. The pressure cooker accelerated the cooking time considerably; however, it negatively influenced the aspects of the cooked mass and had greater water retention. The 15 cassava ethnovarieties present phenotypic variation regarding the texture and colors of the epidermis, cortex, skin, in the fresh pulp and after cooking. Such variation may be indicative of genetic variability, which suggests the need to conserve these cassava ethnovarieties. The evaluation of the culinary characteristics, considering the cooking time and the aspects of the cooked mass, showed that the ethnovarieties Cascatinha, Liberata, Branca 3, Folha roxa, Mandioca de fritar sem cozinhar, Branca 4, Amarelinha 2, Casca roxa, Amarelinha 3 and Casca branca are the most suitable for planting, consumption and commercialization, and can be harvested seven months after planting.

Disengagement from the Ribeirão Preto early intervention program for psychosis: A retrospective cohort study

BackgroundTreatment discontinuation within Early Intervention Services (EIS) for psychosis poses a significant challenge to achieving better outcomes in the early stages of psychotic disorders. Prevalence and predictors of early disengagement from EIS located in low- and middle-income countries (LMICs) remain poorly investigated. We aimed to examine the rates and predictors of disengagement from the Ribeirão Preto Early Intervention Program for Psychosis (Ribeirão Preto-EIP) in Brazil. MethodsWe conducted a retrospective cohort study using data from patients referred to the Ribeirão Preto-EIP between January 01, 2015, and December 31, 2018. Exclusion criteria were individuals with a single consultation, a diagnosis other than a psychotic disorder, and documented cases of death. ResultsOur sample comprised 234 patients, with an overall median follow-up time of 14.2 months. Early treatment disengagement was observed in 26.5 % (n=62), with a median time to disengagement of 5.25 months. Univariable analysis identified non-white skin color (HR=2.10, 95 %CI 1.26–3.49), positive THC screening (HR=2.22, 95 %CI 1.23–4.01), and substance-induced psychosis (HR=2.15, 95 %CI 1.10–4.21) as significant predictors. In multivariable analysis, only non-white skin color remained a significant predictor of early disengagement (HR=1.87, 95 %CI 1.08–3.27). ConclusionsThe observed rates of early disengagement in our sample are similar to those reported in wealthy countries, but higher than previously reported for LMICs. Non-white skin color predicted early disengagement in our sample, probably due to social disadvantages. Our data highlights the need for enhanced research elucidating the specific features of EIS in LMICs.

Targeted metabolomics revealed the seasonal plasticity of skin color and pigment metabolites in ornamental koi carp

The koi carp is an ornamental fish that was obtained through artificial selection from the common carp (Cyprinus carpio L.). The most economically important traits of koi are their beautiful skin patterns in bright colors. As seasonality is an important factor in the biology and ecology of fish, we thus assumed that seasonal changes are involved in regulating the formation of skin color and patterns of koi carp. The white, red, cyan, and black skin colors from four varieties of scaleless koi carp (Doitsu Shiromuji (W), Doitsu Kohaku (WR), Doitsu Showa Sanke (WRI), and Kumonryu (WI)) were evaluated using the CIELab color space (lightness, redness, and yellowness) in different seasons. Compared to winter, the yellowness of the white color in all koi varieties decreased in summer and autumn. The black skin color areas in WRI and WI koi increased in summer and autumn compared to winter. The yellowness of the red color decreased only in WRI koi, while no changes were observed in WR koi. Targeted metabolomics analysis revealed that the levels of the structural pigment guanine of all koi varieties showed significant seasonal variation. Of seven detected carotenoids, the zeaxanthin and tunaxanthin contents in W, WI, and WRI koi changed with the seasons, while none of the carotenoids in WR koi were altered. Of the seven potential regulatory metabolites, epinephrine, melatonin, and cyclic adenosine monophosphate (cAMP) in all four koi varieties showed the highest levels in winter. A correlation analysis suggested that the seasonal changes in white skin color occurred through the epinephrine-cAMP pathway; melanin-dependent and carotenoid-dependent skin color changes occurred through melatonin in koi carp. This study demonstrated the seasonal plasticity of skin color in koi carp regulated by melatonin and epinephrine, associating with variety and color specificity.

A practical classification scale for the dermatology management of individuals with skin of color: the colorimetric scale for skin of color.

A simple and rapid method that is not based on race and ethnicity for classifying people with skin of color is of paramount importance in dermatology. The currently used Fitzpatrick classification of sun-reactive skin types is inadequate. Newer scales that have been used in immigration surveys and sociology studies are not applicable in the office setting. A new, non-racial and non-ethnic, colorimetric scale for skin of color has recently been proposed that is simple to perform. The scale has five colors: very light beige (skin color type 1), light brown (skin color type 2), medium brown (skin color type 3), dark brown (skin color type 4) and very dark brown (skin color type 5); an individual with white skin, such as in albinism, would have a skin color type 0 in this classification. In conclusion, the colorimetric scale enables the rapid classification of individuals with skin of color and allows for accurate assessment of skin cancer risk, more appropriate management of cosmetic dermatologic procedures and aesthetic devices, and enhanced ability for focused counseling regarding hair products, skin care interventions, and color-targeted makeup based on the person's skin tone.

Acne vulgaris in black pediatric patients: clinical presentation, treatment patterns, and unique needs.

Acne vulgaris is a common dermatological diagnosis observed in pediatric patients with skin of color, often resulting in scarring, keloid formation, and post-inflammatory hyperpigmentation, significantly impacting their quality of life. This exploratory retrospective chart review included 77 black pediatric patients seen at a tertiary care center for acne vulgaris between 2018 and 2023. We analyzed demographics, acne descriptors, and treatment modalities. The most common acne morphology was comedonal acne (83.6%), with 71% of the patients being female. Significant age differences were observed particularly for acne at the chin and overall face. Treatment regimens commonly prescribed included combinations of adapalene and benzoyl peroxide (22%), topical antibiotics, tretinoin, and benzoyl peroxide (34%). Given the higher risk of sequelae for patients with darker skin, it is crucial to address their unique treatment needs. This study highlights the distinctive characteristics of acne in black pediatric patients and calls for further research to enhance our understanding and treatment of this population. Limitations include the lack of direct patient interactions and reliance on chart data. Further studies are needed to compare acne presentation in skin of color of other populations, refining our knowledge of acne clinical presentation, complications, and treatment modalities for diverse patient populations.

Effects of a Dietary Supplement Composed of Baicalin, Bromelain and Escin for Venous Chronic Insufficiency Treatment: Insights from a Retrospective Observational Study.

Chronic venous insufficiency (CVI) represents a risk factor for cardiovascular events. The first-line treatment includes the use of compression stockings and lifestyle changes. Natural products, such as flavonoids, could be used to improve the effects of compression therapy due to their anti-inflammatory and anti-oxidant properties. This study aims to evaluate the effects of a dietary supplement containing baicalin, bromeline and escin in CVI patients. A retrospective cohort study was performed by using the medical records of CVI affected outpatients. Patients treated with the dietary supplement were defined as "users". A modified Venous Clinical Severity Score (VCSS) was calculated, including pain, inflammation, vessels induration and skin pigmentation. All clinical variables were evaluated at baseline (T0), after 30 (T1) and 90(T2) days in "users" and "non-users". Out of 62 patients, 30 (48.4%) were "users". No difference was observed between groups at baseline. A lower VCSS value was recorded in "users" than that observed in "non-users" at T2 (7.0 (4.0-9.0) vs. 9.0 (5.0-10.0); p = 0.025). Vessels' induration and pain significantly reduced in 53.3% and 43.3% of "users" and in 18.8% and 9.4% of "non-users". Only "users" (33.3%) showed a reduction of the inflammatory signs as well as a decrease in malleolar circumference, from 29.0 (26.5-30.0) to 27.5 (26.0-28.5) (p < 000.1). A reduction of C-reactive Protein levels was found in "users" compared to "non-users" at T2 (1.0 (0.9-1.2) vs. 1.3 (1.0-1.5); p = 0.006). These findings suggest that implementation of a dietary supplement could improve the clinical outcomes of CVI patients.

Nutritional and bioactive compound analysis of mangosteen fruit in hill and flat land plantations, during both the season and off-season, in provinces along the Gulf of Thailand and the Andaman Sea

This study examined the nutritional, physicochemical, and bioactive compounds in mangosteen grown in southern Thailand from 2022 to 2024, encompassing hilly areas (Nakhon Si Thammarat range, Tenasserim range) and flat lands during both the fruit season and off-season. The influence of coastal regions (Gulf of Thailand and Andaman coast) on mangosteen nutrition was explored. The impact of high-level plantation and harvesting (during the fruit season) on mangosteen size and levels of bioactive compounds with high antioxidant capacity in mangosteen flesh was found to be greater than that of flat plantations (during the off-season). Mangosteens grown in flatlands during the fruit season exhibited brighter flesh color and faster ripening compared to those grown in hilly areas. Mangosteens from these results contained carbohydrates ranging from 10.3% to 16.9%. Mangosteens cultivated along the Andaman coast exhibited elevated levels of minerals (K 349 mg/100 g, Na 7.76 mg/100 g, and Mn 1.63 mg/100 g) and vitamins, especially B2 (0.10 mg/kg), B6 (0.20 mg/kg), B12 (0.03 mg/kg), and vitamin C (9.25 mg/kg). Conversely, the highest total phenolic content, flavonoids, and antioxidant activity were observed in hilly areas during the fruit season along the Gulf of Thailand (55 mg GAE/100 g, 32 mg QE/100 g, and ABTS values of 88%, respectively). However, mangosteens from hilly areas ripened faster than those from flatlands due to higher total soluble solids and lower fruit firmness. These findings provide valuable insights into the effects of the environment and location, enhancing understanding for year-round mangosteen plantation preparation.

Dermatology resident comfort level treating hair conditions related to patients with skin of color.

Although recent studies demonstrated resident satisfaction in the treatment of skin of color (SOC) related disease, comfort levels treating hair specific to populations within the SOC spectrum is unclear. The purpose of this study is to assess dermatology residents comfort level in recognizing and treating various common hair conditions with a focus on those specific to SOC. An Institutional Review Board-approved survey was distributed to United States residents of Accreditation Council for Graduate Medical Education-accredited dermatology programs. Data pertaining to hair care knowledge and treatment comfort levels were collected. Analysis was completed using equal variance 2-sample t tests and analysis of variance F tests, P < .05. Dermatology residents were relatively comfortable with common conditions such as androgenetic alopecia and alopecia areata, but uncomfortable with creating healthy hair regimens, discussing natural hair care products, and treating trichorrhexis nodosa. Resident self-identification as underrepresented in medicine significantly impacted resident knowledge of hair care and treatment in patients with SOC. This study was limited due to small sample size and potential recall bias. This study highlights knowledge gaps in understanding hair-related care for patients with SOC, affirming the continued importance of diversifying dermatology programs as well as hair-specific training for residents.

Accumulation patterns of flavonoids and phenolic acids in different colored sweet potato flesh revealed based on untargeted metabolomics

Sweet potatoes are rich in flavonoids and phenolic acids, showing incomparable nutritional and health value. In this investigation, we comprehensively analyzed the secondary metabolite profiles in the flesh of different-colored sweet potato flesh. We determined the metabolomic profiles of white sweet potato flesh (BS), orange sweet potato flesh (CS), and purple sweet potato flesh (ZS) using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The CS vs. BS, ZS vs. BS, and ZS vs. CS comparisons identified a total of 4447 secondary metabolites, including 1540, 1949, and 1931 differentially accumulated metabolites. Among them, there were significant differences in flavonoids and phenolic acids. There were 20 flavonoids and 13 phenolic acids that were common differential metabolites among the three comparison groups. The accumulation of paeoniflorin-like and delphinidin-like compounds may be responsible for the purple coloration of sweet potato flesh. These findings provide new rationale and insights for the development of functional foods for sweet potatoes. List of compoundsKaempferol (PubChem CID: 5280863); Peonidin 3-(6”-p-coumarylglucoside) (PubChem CID: 44256849); Swerchirin (PubChem CID: 5281660); Trilobatin (PubChem CID: 6451798); 3-Geranyl-4-hydroxybenzoate (PubChem CID: 54730540); Eupatorin (PubChem CID: 97214); Icaritin (PubChem CID: 5318980); Isorhamnetin (PubChem CID: 5281654); Glucoliquiritin apioside (PubChem CID: 74819335); Brazilin (PubChem CID: 73384).

Anti-Melanogenic Activity of Ethanolic Extract from Garcinia atroviridis Fruits Using In Vitro Experiments, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation.

Melanin, the pigment responsible for human skin color, increases susceptibility to UV radiation, leading to excessive melanin production and hyperpigmentation disorders. This study investigated the ethanolic extract of Garcinia atroviridis fruits for its phenolic and flavonoid contents, antioxidant activity, and impact on melanogenesis pathways using qRT-PCR and Western blot analysis. Utilizing network pharmacology, molecular docking, and dynamics simulations, researchers explored G. atroviridis fruit extract's active compounds, targets, and pharmacological effects on hyperpigmentation. G. atroviridis fruit extract exhibited antioxidant properties, scavenging DPPH• and ABTS•+ radicals radicals and chelating copper. It inhibited cellular tyrosinase activity and melanin content in stimulated B16F10 cells, downregulating TYR, TRP-1, phosphorylated CREB, CREB, and MITF proteins along with transcription levels of MITF, TYR, and TRP-2. LC-MS analysis identified thirty-three metabolites, with seventeen compounds selected for further investigation. Network pharmacology revealed 41 hyperpigmentation-associated genes and identified significant GO terms and KEGG pathways, including cancer-related pathways. Kaempferol-3-O-α-L-rhamnoside exhibited high binding affinity against MAPK3/ERK1, potentially regulating melanogenesis by inhibiting tyrosinase activity. Stable ligand-protein interactions in molecular dynamics simulations supported these findings. Overall, this study suggests that the ethanolic extract of G. atroviridis fruits possesses significant antioxidant, tyrosinase inhibitory, and anti-melanogenic properties mediated through key molecular targets and pathways.

Racial inequalities in the development of multimorbidity of chronic conditions: results from a Brazilian prospective cohort

BackgroundThe occurrence of multimorbidity and its impacts have differentially affected population subgroups. Evidence on its incidence has mainly come from high-income regions, with limited exploration of racial disparities. This study investigated the association between racial groups and the development of multimorbidity and chronic conditions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).MethodsData from self-reported white, brown (pardos or mixed-race), and black participants at baseline of ELSA-Brasil (2008–2010) who were at risk for multimorbidity were analysed. The development of chronic conditions was assessed through in-person visits and self-reported diagnosis via telephone until the third follow-up visit (2017–2019). Multimorbidity was defined when, at the follow-up visit, the participant had two or more morbidities. Cumulative incidences, incidence rates, and adjusted incidence rate ratios (IRRs) were estimated using Poisson models.ResultsOver an 8.3-year follow-up, compared to white participants: browns had a 27% greater incidence of hypertension and obesity; and blacks had a 62% and 45% greater incidence, respectively. Blacks also had 58% more diabetes. The cancer incidence was greater among whites. Multimorbidity affected 41% of the participants, with a crude incidence rate of 57.5 cases per 1000 person-years (ranging from 56.3 for whites to 63.9 for blacks). Adjusted estimates showed a 20% higher incidence of multimorbidity in black participants compared to white participants (IRR: 1.20; 95% CI: 1.05–1.38).ConclusionsSignificant racial disparities in the risk of chronic conditions and multimorbidity were observed. Many associations revealed a gradient increase in illness risk according to darker skin tones. Addressing fundamental causes such as racism and racial discrimination, alongside considering social determinants of health, is vital for comprehensive multimorbidity care. Intersectoral, equitable policies are essential for ensuring health rights for historically marginalized groups.

The Effect of National Origin and Skin Color on Playing Time in the WNBA

This article uses data from the 1997–2022 seasons to investigate the role of bias in the distribution of playing time in the WNBA. We evaluate national origin, a fixed and objective measure, and improve upon past uses of subjective, perception-based measures of race by using a more objective measure of skin tone. More specifically, via a fixed-effect estimation of 2,949 WNBA player-year combinations we find no evidence that the national origin of either players or coaches is related to the provision of playing time. Similarly, skin tone of players or coaches ( n = 893), either alone or in combination with national origin, shows no robust significance. Evidence of national origin bias has previously been reported in professional men's basketball leagues in the U.S., Spain, and China. The WNBA may be demographically similar to the National Basketball Association, but it is culturally different and we find no evidence of employer discrimination.