Geographically, Indonesia is located on disaster prone area. Natural disasters such as earthquakes, tsunamis, floods, landslides, volcanic eruptions and non-natural disaster such as Covid-19 Pandemic often occur in various places in Indonesia including in Pidie Jaya, Aceh Province. These disasters have a big influence on many aspects of the socio-economic life of the affected communities. Managing disaster properly will reduce the risk so that it will provide security and resilience community that can anticipate all the impacts of disasters. Collaboration in the form of the Pentahelix Synergy concept involving elements of the Government, Society, Academics, and the Business Industries is one of the important aspect in disaster management. Furthemore, the mass media and the private sector will provide great energy to solve the problem during disaster. This paper discuss about the synergy of Pentahelix in dealing with natural and non-natural disasters in Pidie Jaya Regency, Aceh Province. The results will be useful as lesson learned to support National Security program in Indonesia.