There are more than 14.5 million cancer survivors in the United States in 2016. Although there are no definitive statistics, in one survey of cancer survivors, 46% reported sexual health problems related to the diagnosis and treatment of cancer, and 71% said that they had received no care for sexual dysfunction. The impact of prostate cancer treatments on erectile dysfunction (ED) is well known. However, the review by Voznesensky et al highlights the fact that treatment of men with other malignancies, including bladder, testicular, colorectal, and those treated with marrow or peripheral stemcell transplant, can alsoplayhavoc with erectile function. The authors explain the anatomy and physiology of normal erections and explain how surgery, radiation, chemotherapy, and hormonal therapy can cause ED, dry ejaculation, climacturia (leaking urine during orgasm), or anorgasmia (difficulty reaching orgasm). They provide a thorough discussion of the standard approaches to ED and conclude that patients should be referred to urologists for treatment of cancer-related ED.