Physicochemical Properties Of Blends Research Articles

FORMULATION AND DEVELOPMENT OF SUSTAINED RELEASED GLICLAZIDE TABLETS WITH THE DIFFERENT HYDROPHILIC POLYMER BY USING DIRECT COMPRESSION

To effectively manage the diabetic mellitus type-II hyperglycemic problem, Gliclazide tablet is the sustained- release tablet that has been designed and fabricated for years. This research evaluated the effects of different grades of hydrophilic polymers in sustained release of Gliclazide tablets made with direct compression technique. HPC GF GRADE, HPMC K4M, and PARTECK® SRP 80 were used as the polymer, Avicel pH 101 (MCC) was used as the highly compressible diluent and Starch 1500 was used as insoluble tablet filler. Aerosil 300 and Magnesium Stearate was used as a Glidant and lubricant for improving the flow property of powder and to decrease the friction between dying wall and punches. Pre-compression characteristics were evaluated for angle of repose, bulk density, compressibility, tapped density, and Hausner's ratio and DSC, XRD, FT-IR. Tablets were prepared on a rotary tablet press machine (Eliza press) and after compression tablets were evaluated for weight variation, thickness, hardness, friability, drug content, and in-vitro drug release study. The physico-chemical properties of blends were estimated accelerated stability study was also developed formulations were kept for stability study for three months as per ICH guidelines and found to be stable. Advantages of formulating insoluble drugs such as Gliclazide is that if it is used in the preparation of capsules or tablets of the drug,its dose might be reduced which is economically beneficial.

Key fuel properties and engine performances of diesel-ethanol blends, using tetrahydrofuran as surfactant additive

In this paper there were presented researches related to preparation and characterization of physicochemical properties of diesel-ethanol blends stabilized with tetrahydrofuran as surfactant, in order to be used as fuels in compression ignition engines. The main spray characteristics and engine performances of these blends were evaluated by using AVL Fire software. In the first stage of the studies, commercial diesel was mixed with ethanol, in different concentrations (between 2% and 15% v/v), followed by the addition of tetrahydrofuran (THF) until the blends were miscible, i.e. the blends were stabilized. The experiments were done at room temperature (22 °C). The obtained blends were characterized in order to determine the chemical composition and physicochemical properties, i.e. density, kinematic viscosity, surface tension. UV-Vis spectroscopy was utilized in order to determine a semi-quantitative evaluation regarding the chemical composition of the prepared blends and chemical interaction between diesel, ethanol and THF. Based on the determined properties, the fuel spray characteristics, engine performances and emission characteristics were evaluated by simulation using the AVL Fire software. The obtained results regarding physicochemical properties of blends were compared with diesel. Some improvements were observed when operating with the prepared blends compared to diesel with respect to engine performances and emission characteristics. Based on physicochemical evaluation and computer simulation, it was demonstrated that diesel-ethanol-tetrahydrofuran blends can be used as alternative fuel in compression ignition engines.

Investigation of the effects of starch on the physical and biological properties of polyacrylamide (PAAm)/starch nanofibers

Here, we report the development of a new polyacrylamide (PAAm)/starch nanofibers’ blend system and highlight its potential as substrate for efficient enzyme immobilization. PAAm was synthesized and blended with starch. The final blend was then electrospun into nanofibers. The response surface methodology was used to analyze the parameters that control nanofiber’s diameter. Electrospun mat was then modified either by cross-linking or phytase immobilization using silane coupling agent and glutaraldehyde chemistry. Physico-chemical properties of blends were investigated using spectroscopic and thermal studies. The evaluation of immobilized enzyme kinetics on both pure and the starch blended PAAm nanofibers was performed using Michaelis–Menten kinetic curves. Fourier transform infrared spectroscopy results along with differential scanning and X-ray diffraction confirmed that blending was successfully accomplished. TGA analysis also demonstrated that the presence of starch enhances the thermal degradability of PAAm nanofibers. Finally, it was shown that addition of starch to PAAm increases the efficacies of enzyme loading and, therefore, significantly enhances the activity as well as kinetics of the immobilized enzyme on electrospun blend mats.

Perspectives on Physicochemical Properties and Application of Biodiesel Blends

This paper analyzes a series of physicochemical properties of biodiesel blends, then explores the effect of biodiesel content on physicochemical properties of the blended fuel and the application prospects of biodiesel.

Optical Properties and Morphological Structure of Electron Beam Irradiated Low-Density Polyethylene/Polypropylene Blends

ABSTRACT Blending is an effective method for improving the physical and chemical properties of homopolymers. However, the problem of phase separation often in some polymer blends occurs due to incompatibility of homopolymer, which impairs the expected physico-chemical properties of blends. In this study, isotactic polypropylene (PP) was blended with low density polyethylene (LDPE) in the presence of various ratios of polyfunctional monomer (PFM), namely, trimethylol propane trimethacrylate (TMPTMA) as a cross-linking and/or compatibilizing agents. The electron beam irradiation of the investigated LDPE/PP blends was carried out at different irradiation doses up to 50 kGy to improve the compatibility of LDPE/PP blends. The dye affinity for disperse and basic dyes of LDPE, PP, and LDPE/PP blends was investigated in terms of color strength and visible absorbance intensities. In addition, the microstructures of the investigated samples have been studied, and it is considered as an indication of the compatibility of LDPE/PP blend. The results show that the unmodified and PFM modified LDPE samples show the highest values of both color strength and visible absorbance intensities compared with unmodified and PFM modified PP samples. The intensities of these values in the LDPE/PP blends also decrease as the PP content increases in the blend. In addition, the increase of EB irradiation dose and PFM ratios leads to an increase in the values of color strength and visible absorbance intensities. Moreover, the affinity of all investigated samples toward disperse dye is being more pronounced than the basic dye. The interfacial adhesion of LDPE/PP blend could be enhanced by adding cross-linking agent (TMPTMA) and EB irradiation process with different irradiation doses. The obtained data for the microstructures of all the investigated samples support that the EB irradiation beside the incorporation of PFM into the homopolymer matrix remarkably improve the compatibility of the polymer blend.