The development of quantum mechanics and quantum physics in general is one of the greatest intellectual achievements of the 20th century. Initially, quantum physicists focused on mathematically describing and understanding the laws of a micro-world, comprised of atoms, molecules and photons. Nuclei and sub-atomic particles were discovered, particle physics evolved, and complex quantum systems in chemistry and solid-state physics are now described in terms of quantum physics. Within a century, quantum physics became the framework, which allows us to describe and predict, albeit with probabilities, the behavior of the microscopic world as we know it. The powerful quantum framework led to revolutionary technical advances for a century, such as semiconductor technology and the entire electronics industry based on it, enabling computers and the information age. The development of lasers found applications in many areas of our current technologies; we use them for printers, storing and retrieving information using CDs, industrial welding, medical surgery, and for range finding and communication purposes. Medical imaging using MRI is now a routine instrument, as are precision measurements using tunneling and atomic force microscopes. Superconducting technologies are used for high magnetic fields and many more current technologies are based on and enabled by the laws of quantum physics. While the framework of quantum physics has thus proven to be extremely successful and powerful, throughout the last century there were many conceptual, and to some extent philosophical, discussions on our understanding of quantum physics. As early as the 1930s, Einstein and Schrödinger realized that quantum physics allows for some peculiar states, which Schrödinger called “entangled”, which have a non-local character and thus do find an easy interpretation in our classical world. It took a few more decades until John Bell conceived a way to quantify such states, which thus became amenable to measurements. Only in the eighties and nineties of the last century did the generation of entangled states, their characterization and their subsequent application become feasible and accessible in laboratories. Early on, Bell states were proposed for applications in quantum communication, employing protocols based on teleportation. Soon, entanglement was recognized to be useful also for sensing, for precision measurements and eventually for quantum information processing. Starting with the early concept of a trapped-ion quantum computer introduced by Ignacio Cirac and Peter Zoller in 1995, many other platforms were proposed for quantum information processing, based on superconducting quantum bits, photonic processes, engineered quantum dots and many more. The first decade of the 21st century saw an explosive development of quantum information physics, which is by now a mature field and increasingly focuses on applications. Worldwide efforts are ongoing to realize quantum networks for secure communication and to implement quantum computers. Enhanced sensing has been demonstrated using advanced quantum states, and quantum simulators have been developed, already tackling problems that are hard to compute with classical computers. While architectures for full-fledged quantum computers are already available, the realization of such computers still requires the routine implementation of error correction, which is not yet available, for full scalability. Currently, noisy intermediate-scale quantum (NISQ) processors are already used for computations and are even accessible via cloud services. Since about 2000, quantum technologies have been developed for many platforms with the aim to surpass the capablities of their classical counterparts. Many such devices now make use of entangled states, which are seen as the new resource for advanced quantum technologies. For this, describing, understanding and generally mastering the generation and manipulation of entanglement is a key element. Moreover, both hardware and software technologies have to be improved in order to better control quantum devices. Mastering quantum phenomena for communication, metrology, simulation and computation purposes is currently one of the hottest topics in science since the wide applicability of quantum technologies will revolutionize these fields. The development of advanced quantum technologies is thus seen worldwide as a strategic area for generating technical knowledge and industrial evolution. This special issue intends to showcase the breadth and impact of the ongoing research in advancing quantum technologies. We have invited a selection of renowned scientists to present their work, and we are confident that this issue will find a broad readership and attract much interest within the scientific community.