The MOF-derived Fe2O3/C/In2O3 heterogeneous materials combined with vitamin C (AA) were first designed to construct a photo-Fenton system for the decomposition of tetracycline (TC). In this work, comparative analysis of TC degradation efficiency, photoluminescence (PL), ultraviolet-visible diffuse reflectance spectroscopy (UV–vis DRS), and transient photocurrent (I-T) performance analysis revealed that the heterojunctions not only effectively promoted the response of visible light by the catalytic system, but also facilitated the separation of photogenerated electrons and holes to increase electron density, thus, the conversion efficiency of Fe3+/Fe2+ was effectively improved, and hydrogen peroxide was activated to generate ・OH. Besides, the conversion efficiency of Fe3+/Fe2+ has been further improved due to the addition of AA, which provides many active electrons for heterogeneous materials. The capture experiments revealed that the active substances (・OH, h+, and ・O-2) played a main role in the degradation of TC. The system degraded high concentrations of TC with the efficiency of 88.9 % within 60 min. The strategy provided a new method for improving the photo-Fenton advanced oxidation performance of Fe2O3.