Cultivation of microalgae and controlling its growth and performance in closed photobioreactors (PBRs) are easier than open pond systems for wastewater treatment. The performance of PBRs is influenced by geometry, hydrodynamic behavior, and mass transfer. Horizontal and vertical configurations as common designs of PBR are reviewed based on their features, advantages, and disadvantages. However, vertically operated PBRs like bubble columns are preferably used for utility-scale applications of microalgae-based processes. Moreover, an appropriate reactor design reduces the inhibitory effect of dissolved oxygen concentration produced by microalgae and consequently increases the level of available CO2 in the medium. Medium properties, superficial gas velocity, gas holdup, bubble sizes, shear stress, mixing time, sparger design, and the ratio of inner diameter to effective height are shown to influence the overall volumetric mass transfer coefficient (KLa) and PBR's performance. The vertical PBRs like bubble columns provide a high mass transfer, a short liquid circulation time, and a long frequency of light/dark cycle for utility application of microalgae. Different flow regimes are obtained in PBRs based on the gas flow rate, inner diameter, and medium properties. Hydraulic retention time as the main operational parameter is determined in a batch mode for continuous wastewater treatment.
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