Captive raised tadpoles were used to investigate the relationship between multilocus heterozygosity at nine electrophoretically detected loci and several important life-history parameters in the spotted chorus frog, Pseudacris clarkii. No significant correlation was found between multilocus heterozygosity and weight early in the larval period, weight at forelimb emergence, or weight at tail resorption. When the effect of weight at metamorphosis was removed, a weak, inverse correlation was observed between length of the larval period and multilocus heterozygosity-tadpoles with more heterozygous loci metamorphosed sooner than tadpoles with few heterozygous loci. Heterozygosity at an alcohol dehydrogenase locus contributed most to this relationship. Significant differences in growth rates were observed for genotypes at a phosphoglucomutase locus, but homozygotes were heavier than heterozygotes.