Objective To evaluate the clinical effect and safety of intravenous administration of phloroglucinol combined with delivery of ball-assisted free position in parturient women during labor. Methods One hundred and fifty-two primiparous women who were treated by vaginal delivery from June 2015 to August 2016 in Beijing Navy General Hospital were selected as the study subjects.They were given 80 mg of phloroglucinol diluted in saline injection intravenous injection.Observation group were treated with childbirth.Control group treated with traditional supine or lateral body. Results The rate of descending of the observed group was longer than that of the control group((1.09±0.22) cm/h vs.(0.83±0.15) cm/h), the first labor time, the second labor time and the total labor time of the observation group were shorter than the control group((9.57±1.71) h vs.(12.13±2.64) h, (35.75±8.68) min vs.(61.21±10.03) min, (11.34±1.96) h vs.(14.66±2.70) h), the difference between the two groups was statistically significant(t=3.611, 4.204, 3.307, 3.456, P 0.05). The percentage of vaginal delivery in the observation group was 89.47%(68/76), significantly higher than that in the control group(73.68%(56/76)), the difference was statistically significant(χ2=4.514, P<0.05). The incidence of vaginal midwifery was 1.32%(1/76) and that of cesarean section was 9.21%(7/76) of observation group, significantly lower than that in control group(5.26%(4/76), 21.05% (16/76)), the difference was statistically significant(χ2=5.323, 4.376, P<0.05). Observation group 24 h postpartum hemorrhage was (273.12±58.23) ml, significantly less than the control group((385.42±70.13) ml), the difference between the two groups was statistically significant(t=3.744, P<0.05). The observation group had postpartum hemorrhage of 1.32%(1/76), urinary retention of 2.63%(2/76), and the percentage of neonatal asphyxia of 2.63%(2/76), were lower than that of the control group(5.26%(4/76), 10.53%(8/76), 9.21%(7/76)), the difference between the two groups was statistically significant(χ2=4.103, 4.925, 4.421, P<0.05). Conclusion The delivery of ball-assisted free-body delivery in active stage of delivery can promote natural childbirth.The medical staff should update the concept of delivery and raise awareness to encourage the use of phloroglucinol combined with free-body delivery. Key words: Active phase; Phloroglucinol; Delivery ball; Free postural delivery