<p class="Abstract">Nick Bostrom, a transhumanist figure, referred human
 perfection on three pillars: including super longevity (super long life), super
 wellbeing (super happy) and super intelligence (super intelligent). This cyborg
 human model adheres to the epistemology of scientism which he values as
 anti-traditionalist culture, religious dogmas and metaphysics, but in principle
 ostrom bases his perfect human model on Nietzsche <i>(Der ubermensch)</i>,
 whereas scientism in Nietzsche's view is a form of religious ideas in a certain
 degree. This paper attempts to reveal the epistemological paradox of Bostrom's
 concept of transhumanism through Nietzsche's genealogical philosophy and its
 epistemological implications. The method used in this research is an
 epistemological and genealogical analysis on the three main pillars of Bostrom
 which are the basic foundations of its transhumanism. In this study, it is
 found first that the Bostrom paradox occurs not only in the misinterpretation
 of a perfect man, where Bostrom considers the fulfillment of the three pillars,
 whereas what Nietzsche means is as an independent human being in the sense of
 two things, namely: able to govern himself and be united or only rely on
 himself, and not relying on external reality or dogma. The second, paradoxes occur
 in the belief system of the pillars of Bostrom's transhumanism where he relies
 on the absolutism of science and negates all assumptions or arguments that come
 from metaphysics and religion. Meanwhile, what Nietzsche means is to hold on to
 the relativity of truth where humans will be weak and flawed if they rely on
 beliefs outside themselves, including science.&nbsp;<o:p></o:p></p>