Abstract As superconducting quantum computing continues to advance at an unprecedented pace, there is a compelling demand for the innovation of specialized electronic instruments that act as crucial conduits between quantum processors and host computers. Here, we introduce a Microwave Measurement and Control System (M2CS) dedicated for large-scale superconducting quantum processors. M2CS features a compact modular design that balances overall performance, scalability and flexibility. Electronic tests of M2CS show key metrics comparable to commercial instruments. Benchmark tests on transmon superconducting qubits further show qubit coherence and gate fidelities comparable to state-of-the-art results, confirming M2CS’s capability to meet the stringent requirements of quantum experiments run on intermediate-scale quantum processors. The compact and scalable nature of our design holds the potential to support over 1000 qubits after upgrade in stability and integration. The M2CS architecture may also be adopted to wider range of scenarios, including other quantum computing platforms such as trapped ions and silicon quantum dots, as well as more traditional applications like microwave kinetic inductance detectors, phased array radar systems.