The efficiency of mineral fertilizers depends upon various factors, one of which is fertilization method. In heterogeneous condition of fields of nutrient content, the benefits of variable rate fertilization will increase, cause as much fertilizer will be applied to each section of the field as is necessary specifically on this section to obtain the planned yield. Experimental results have revealed the following features: variable rate fertilizer of nitrogen to reduce the variability of the nitrate nitrogen content in the tillering phase of spring wheat to 36% relative to the content before sowing, variable rate fertilizer of phosphorus and potassium to reduce variability of labile phosphorus and potassium in soil to the phase of wheat harvesting by 11 and 21%. The fertilization of one rate is less effective. This method leads to a decrease in the variability of nitrate nitrogen to 48%, labile phosphorus by 10%, by variability of labile potassium increases by 17% in the same time. Yield of spring wheat was 4.36-4.46 t / ha with a protein content of 14.03-14.57%, wet gluten 33.0-35.0%, glassiness 87-88%, weight of 1000 grain 36.1-36.3 g were applied with variable rate fertilizers in off-line mode.