Phase Aberration Correction Research Articles

Spatial Prediction Filtering for Medical Ultrasound in Aberration and Random Noise.

While medical ultrasound imaging has become one of the most widely used imaging modalities in clinics, it often suffers from suboptimal image quality, especially in technically difficult patients with a large amount of fat content that induces severe phase aberration effects and decreases the signal-to-noise ratio. Several researchers have proposed various techniques, which can be broadly categorized as either a phase aberration correction (PAC) technique or a coherence-based imaging technique, to address the challenges in imaging technically difficult patients. Although both families of techniques have shown some success in improving the image quality in the presence of a mild level of phase aberration and/or random noise, they often fail to achieve meaningful improvements in the image quality and, in some cases, even create severe image artifacts. In this paper, we employ an adaptive filtering technique called frequency-space prediction filtering (FXPF), which we recently introduced in ultrasound imaging, to overcome the weaknesses of existing techniques and achieve image quality improvements more effectively under varying levels of phase aberration and random noise. Using simulated and experimental phantom data with varying levels of phase aberration and random noise, we evaluate and compare the performance of FXPF with the most representative technique for each category: nearest-neighbor cross correlation (NNCC)-based PAC and the generalized coherence factor (GCF). Our simulation, experimental phantom, and in vivo results demonstrate that FXPF is highly robust in varying levels of phase aberration and noise, and always outperforms both NNCC-based PAC and GCF in terms of the contrast-to-noise ratio (CNR) and the contrast when both random noise and phase aberration are present.

Experimental assessment of phase aberration correction for breast MRgFUS therapy

Purpose: This study validates that phase aberrations in breast magnetic resonance-guided focussed ultrasound (MRgFUS) therapies can be corrected in a clinically relevant time frame to generate more intense, smaller and more spatially accurate foci.Materials and methods: Hybrid angular spectrum (HAS) ultrasound calculations in an magnetic resonance imaging (MRI)-based tissue model, were used to compute phase aberration corrections for improved experimental MRgFUS heating in four heterogeneous breast-mimicking phantoms (n = 18 total locations). Magnetic resonance(MR) temperature imaging was used to evaluate the maximum temperature rise, focus volume and focus accuracy for uncorrected and phase aberration-corrected sonications. Thermal simulations assessed the effectiveness of the phase aberration correction implementation.Results: In 13 of 18 locations, the maximum temperature rise increased by an average of 30%, focus volume was reduced by 40% and focus accuracy improved from 4.6 to 3.6 mm. Mixed results were observed in five of the 18 locations, with focus accuracy improving from 6.1 to 2.5 mm and the maximum temperature rise decreasing by 8% and focus volume increasing by 10%. Overall, the study demonstrated significant improvements (p < 0.005) in maximum temperature rise, focus volume and focus accuracy. Simulations predicted greater improvements than observed experimentally, suggesting potential for improvement in implementing the technique. The complete phase aberration correction procedure, including model generation, segmentation and phase aberration computations, required less than 45 min per sonication location.Conclusion: The significant improvements demonstrated in this study i.e., focus intensity, size and accuracy from phase aberration correction have the potential to improve the efficacy, time-efficiency and safety of breast MRgFUS therapies.

The Impact of Model-Based Clutter Suppression on Cluttered, Aberrated Wavefronts.

Recent studies reveal that both phase aberration and reverberation play a major role in degrading ultrasound image quality. We previously developed an algorithm for suppressing clutter, but we have not yet tested it in the context of aberrated wavefronts. In this paper, we evaluate our previously reported algorithm, called aperture domain model image reconstruction (ADMIRE), in the presence of phase aberration and in the presence of multipath scattering and phase aberration. We use simulations to investigate phase aberration corruption and correction in the presence of reverberation. As part of this paper, we observed that ADMIRE leads to suppressed levels of aberration. In order to accurately characterize aberrated signals of interest, we introduced an adaptive component to ADMIRE to account for aberration, referred to as adaptive ADMIRE. We then use ADMIRE, adaptive ADMIRE, and conventional filtering methods to characterize aberration profiles on in vivo liver data. These in vivo results suggest that adaptive ADMIRE could be used to better characterize a wider range of aberrated wavefronts. The aberration profiles' full-width at half-maximum of ADMIRE, adaptive ADMIRE, and postfiltered data with 0.4- mm-1 spatial cutoff frequency are 4.0 ± 0.28 mm, 2.8 ± 1.3 mm, and 2.8 ± 0.57 mm, respectively, while the average root-mean square values in the same order are 16 ± 5.4 ns, 20 ± 6.3 ns, and 19 ± 3.9 ns, respectively. Finally, because ADMIRE suppresses aberration, we perform a limited evaluation of image quality using simulations and in vivo data to determine how ADMIRE and adaptive ADMIRE perform with and without aberration correction.

Effects of Phase Aberration and Phase Aberration Correction on the Minimum Variance Beamformer.

The minimum variance (MV) beamformer has the potential to enhance the resolution and contrast of ultrasound images but is sensitive to steering vector errors. Robust MV beamformers have been proposed but mainly evaluated in the presence of gross sound speed mismatches, and the impact of phase aberration correction (PAC) methods in mitigating the effects of phase aberration in MV beamformed images has not been explored. In this study, an analysis of the effects of aberration on conventional MV and eigenspace MV (ESMV) beamformers is carried out. In addition, the impact of three PAC algorithms on the performance of MV beamforming is analyzed. The different beamformers were tested on simulated data and on experimental data corrupted with electronic and tissue-based aberration. It is shown that all gains in performance of the MV beamformer with respect to delay-and-sum (DAS) are lost at high aberration strengths. For instance, with an electronic aberration of 60 ns, the lateral resolution of DAS degrades by 17% while MV degrades by 73% with respect to the images with no aberration. Moreover, although ESMV shows robustness at low aberration levels, its degradation at higher aberrations is approximately the same as that of regular MV. It is also shown that basic PAC methods improve the aberrated MV beamformer. For example, in the case of electronic aberration, multi-lag reduces degradation in lateral resolution from 73% to 28% and contrast loss from 85% to 25%. These enhancements allow the combination of MV and PAC to outperform DAS and PAC and ESMV in moderate and strong aberrations. We conclude that the effect of aberration on the MV beamformer is stronger than previously reported in the literature and that PAC is needed to improve its clinical potential.

Rapid full-wave phase aberration correction method for transcranial high-intensity focused ultrasound therapies.

BackgroundNon-invasive high-intensity focused ultrasound (HIFU) can be used to treat a variety of disorders, including those in the brain. However, the differences in acoustic properties between the skull and the surrounding soft tissue cause aberrations in the path of the ultrasonic beam, hindering or preventing treatment.MethodsWe present a method for correcting these aberrations that is fast, full-wave, and allows for corrections at multiple treatment locations. The method is simulation-based: an acoustic model is built based on high-resolution CT scans, and simulations are performed using the hybrid angular spectrum (HAS) method to determine the phases needed for correction.ResultsComputation of corrections for clinically applicable resolutions can be achieved in approximately 15 min. Experimental results with a plastic model designed to mimic the aberrations caused by the skull show that the method can recover 95 % of the peak pressure obtained using hydrophone-based time-reversal methods. Testing using an ex vivo human skull flap resulted in recovering up to 70 % of the peak pressure at the focus and 61 % when steering (representing, respectively, a 1.52- and 1.19-fold increase in the peak pressure over the uncorrected case). Additionally, combining the phase correction method with rapid HAS simulations allows evaluation of such treatment metrics as the effect of misregistration on resulting pressure levels.ConclusionsThe method presented here is able to rapidly compute phases required to improve ultrasound focusing through the skull at multiple treatment locations. Combining phase correction with rapid simulation techniques allows for evaluation of various treatment metrics such as the effect of steering on pressure levels. Since the method computes 3D pressure patterns, it may also be suitable for predicting off-focus hot spots during treatments—a primary concern for transcranial HIFU. Additionally, the plastic-skull method presented here may be a useful tool in evaluating the effectiveness of phase correction methods.

Adaptive illumination based on direct wavefront sensing in a light-sheet fluorescence microscope.

A methodology for the adaptive control and correction of phase aberrations in the illumination arm of a light-sheet fluorescence microscope has been developed. The method uses direct wavefront sensing on epi-fluorescent light to detect the aberration present in the sample. Using this signal, the aberrations in the illumination arm are subsequently corrected with a spatial light modulator in a feedforward mode. Adaptive correction, resulting in significant improvement in the axial resolution, has been demonstrated by imaging Tg(fli:GFP) zebrafish embryos.

A method for phase aberration correction of high intensity focused ultrasound fields using acoustic nonlinearity

High intensity focused ultrasound (HIFU) therapies are often affected by aberrations induced by soft tissue heterogeneities. To mitigate these aberrations, phase corrections at different elements of a HIFU transducer array can be introduced, if suitable feedback is available. Existing feedback approaches include maximization of focal tissue displacement induced by acoustic radiation force or scattering from a cavitation bubble nucleated at the focus. Here we propose an aberration correction method based on backscattering of strongly nonlinear HIFU waves that are present only at the focus. A 1.5 MHz, 12-element sector array was integrated with a coaxially aligned imaging probe (P7-4). Each element of the array emitted a short, high-amplitude pulse through the aberrative layer toward the focus in tissue, and the imaging probe recorded the backscattered signal at higher frequencies. The focusing gain of each sector element was sufficient to generate a highly nonlinear focal waveform, which allowed localizing...

Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array.

Transcranial focused ultrasound (FUS) shows great promise for a range of therapeutic applications in the brain. Current clinical investigations rely on the use of magnetic resonance imaging (MRI) to monitor treatments and for the registration of preoperative computed tomography (CT)-data to the MR images at the time of treatment to correct the sound aberrations caused by the skull. For some applications, MRI is not an appropriate choice for therapy monitoring and its cost may limit the accessibility of these treatments. An alternative approach, using high frequency ultrasound measurements to localize the skull surface and register CT data to the ultrasound treatment space, for the purposes of skull-related phase aberration correction and treatment targeting, has been developed. A prototype high frequency, hemispherical sparse array was fabricated. Pulse-echo measurements of the surface of five ex vivo human skulls were made, and the CT datasets of each skull were obtained. The acoustic data were used to rigidly register the CT-derived skull surface to the treatment space. The ultrasound-based registrations of the CT datasets were compared to the gold-standard landmark-based registrations. The results show on an average sub-millimeter (0.9 ± 0.2 mm) displacement and subdegree (0.8° ± 0.4°) rotation registration errors. Numerical simulations predict that registration errors on this scale will result in a mean targeting error of 1.0 ± 0.2 mm and reduction in focal pressure of 1.0% ± 0.6% when targeting a midbrain structure (e.g., hippocampus) using a commercially available low-frequency brain prototype device (InSightec, 230 kHz brain system). If combined with ultrasound-based treatment monitoring techniques, this registration method could allow for the development of a low-cost transcranial FUS treatment platform to make this technology more widely available.

Effects of phase aberration correction methods on the minimum variance beamformer.

The minimum variance (MV) beamformer is a method that has the potential to enhance the resolution and contrast of ultrasound images. However, it suffers from sensitivity to speed of sound errors and aberration. Although there have been several studies on the application of phase aberration correction (PAC) methods to conventional delay-and-sum (DAS) beamforming, the benefits of PAC methods in mitigating the effects of phase aberration in MV beamformed images are not well understood. A study of this type would be helpful in designing a robust beamformer based on PAC knowledge present in the literature. This study analyzes three PAC algorithms (multi-lag cross-correlation, Rigby's beamsum and scaled covariance matrix) and their impact on the performance of the MV beamformer in the presence of second order phase aberrations. The PAC methods in combination with the MV beamformer were tested on simulated and experimental data corrupted with an electronically created near field phase aberrator. It is shown that all gains in performance of the MV beamformer with respect to DAS is lost at high aberration strengths. For instance, at 60 ns of aberration the lateral resolution of DAS degrades by 22% while MV degrades by 600%. It is also shown that basic PAC methods improve the aberrated MV beamformer. PAC methods reduces degradation in lateral resolution from 600% to 5%. Similar improvements are observed in peak sidelobe level (96% to 27%), contrast (88% to 49% for the simulations and 43% to 15% for experiments) and contrast-to-noise ratio (86% to 42% for the simulations and 68% to 55% for experiments). These enhancements allow the MV beamformer to outperform DAS even in the strongest aberration case.

Performance of a simulation-based phase aberration correction technique in transcranial ultrasound modeling

Due to its irregular geometry and acoustic properties, the presence of the skull in transcranial focused ultrasound therapies can lead to considerable beam phase aberration, resulting in distorted focal spots. There are several possible techniques for correcting this phase aberration with a phased-array transducer, the most accurate of which (although invasive) is hydrophone-based time reversal. There are also simulation-based approaches, and here we exploit the time-advantages of the Hybrid Angular Spectrum (HAS) numerical method and apply it to two models of the skull: a 3D-printed plastic skull analog and a segment of a human skull for which a CT scan has been obtained. We compare the focused pressure patterns—obtained via hydrophone scans—for the cases of no phase correction, hydrophone-based phase correction, and simulation-based (HAS) phase correction. We show the degree to which the correction methods improve the focal spot quality, pressure amplitude, and localization accuracy. The very good results for the analog model compared to results for the skull segment indicate that better mapping of CT Hounsfield units to acoustic properties of the bone is needed. In addition, we use the simulation technique to predict the effects of beam steering and transducer/model misregistration on the effectiveness of aberration correction.

Phase aberration simulation study of MRgFUS breast treatments.

This simulation study evaluates the effects of phase aberration in breast MR-guided focused ultrasound (MRgFUS) ablation treatments performed with a phased-array transducer positioned laterally to the breast. A quantification of these effects in terms of thermal dose delivery and the potential benefits of phase correction is demonstrated in four heterogeneous breast numerical models. To evaluate the effects of varying breast tissue properties on the quality of the focus, four female volunteers with confirmed benign fibroadenomas were imaged using 3T MRI. These images were segmented into numerical models with six tissue types, with each tissue type assigned standard acoustic properties from the literature. Simulations for a single-plane 16-point raster-scan treatment trajectory centered in a fibroadenoma in each modeled breast were performed for a breast-specific MRgFUS system. At each of the 16 points, pressure patterns both with and without applying a phase correction technique were determined with the hybrid-angular spectrum method. Corrected phase patterns were obtained using a simulation-based phase aberration correction technique to adjust each element's transmit phase to obtain maximized constructive interference at the desired focus. Thermal simulations were performed for both the corrected and uncorrected pressure patterns using a finite-difference implementation of the Pennes bioheat equation. The effect of phase correction was evaluated through comparison of thermal dose accumulation both within and outside a defined treatment volume. Treatment results using corrected and uncorrected phase aberration simulations were compared by evaluating the power required to achieve a 20 °C temperature rise at the first treatment location. The extent of the volumes that received a minimum thermal dose of 240 CEM at 43 °C inside the intended treatment volume as well as the volume in the remaining breast tissues was also evaluated in the form of a dose volume ratio (DVR), a DVR percent change between corrected and uncorrected phases, and an additional metric that measured phase spread. With phase aberration correction applied, there was an improvement in the focus for all breast anatomies as quantified by a reduction in power required (13%-102%) to reach 20 °C when compared to uncorrected simulations. Also, the DVR percent change increased by 5%-77% in seven out of eight cases, indicating an improvement to the treatment as measured by a reduction in thermal dose deposited to the nontreatment tissues. Breast compositions with a higher degree of heterogeneity along the ultrasound beam path showed greater reductions in thermal dose delivered outside of the treatment volume with correction applied than beam trajectories that propagated through more homogeneous breast compositions. An increasing linear trend was observed between the DVR percent change and the phase-spread metric (R(2) = 0.68). These results indicate that performing phase aberration correction for breast MRgFUS treatments is beneficial for the small-aperture transducer (14.4 × 9.8 cm) evaluated in this work. While all breast anatomies could benefit from phase aberration correction, greater benefits are observed in more heterogeneous anatomies.

Modal-based phase retrieval for adaptive optics.

We consider using phase retrieval (PR) to correct phase aberrations in an optical system. Three measurements of the point-spread function (PSF) are collected to estimate an aberration. For each measurement, a different defocus aberration is applied with a deformable mirror (DM). Once the aberration is estimated using a PR algorithm, we apply the aberration correction with the DM, and measure the residual aberration using a Shack-Hartmann wavefront sensor. The extended Nijboer-Zernike theory is used for modelling the PSF. The PR problem is solved using both an algorithm called PhaseLift, which is based on matrix rank minimization, and another algorithm based on alternating projections. For comparison, we include the results achieved using a classical PR algorithm, which is based on alternating projections and uses the fast Fourier transform.

A full-wave phase aberration correction method for transcranial high-intensity focused ultrasound brain therapies.

Transcranial high-intensity focused ultrasound has recently been used to noninvasively treat several types of brain disorders. However, due to the large differences in acoustic properties of skulls and the surrounding soft tissue, it can be a challenge to adequately focus an ultrasonic beam through the skull. We present a novel, fast, full-wave method of correcting the aberrations caused by the skull by phasing the elements of a phased-array transducer to create constructive interference at the target. Because the method is full-wave, it also allows for trajectory planning by determining the phases required for multiple target points with negligible additional computational costs. Experimental hydrophone scans with an ex vivo skull sample using a 256-element 1-MHz transducer show an improvement of 6.2% in peak pressure at the focus and a reduction of side-lobe pressure by a factor of 2.31. Additionally, mispositioning of the peak pressure from the intended treatment location is reduced from 2.3 to 0.5 mm.

Axial ultrasound B-scans of the entire eye with a 20-MHz linear array: correction of crystalline lens phase aberration by applying Fermat's principle.

In ophthalmic ultrasonography the crystalline lens is known to be the main source of phase aberration, causing a significant decrease in resolution and distortion effects on axial B-scans. This paper proposes a computationally efficient method to correct the phase aberration arising from the crystalline lens, including refraction effects using a bending ray tracing approach based on Fermat's principle. This method is used as a basis to perform eye-adapted beamforming (BF), with appropriate focusing delays for a 128-element 20-MHz linear array in both emission and reception. Implementation was achieved on an in-house developed experimental ultrasound scanning device, the ECODERM. The proposed BF was tested in vitro by imaging a wire phantom through an eye phantom consisting of a synthetic gelatin lens anatomically set up in an appropriate liquid (turpentine) to approach the in vivo velocity ratio. Both extremes of accommodation shapes of the human crystalline lens were investigated. The performance of the developed BF was evaluated in relation to that in homogeneous medium and compared to a conventional delay-and-sum (DAS) BF and a second adapted BF which was simplified to ignore the lens refraction. Global expectations provided by our method with the transducer array are reviewed by an analysis quantifying both image quality and spatial fidelity, as well as the detrimental effects of a crystalline lens in conventional reconstruction. Compared to conventional array imaging, the results indicated a two-fold improvement in the lateral resolution, greater sensitivity and a considerable reduction of spatial distortions that were sufficient to envisage reliable biometry directly in B-mode, especially phakometry.

High-contrast imaging in polychromatic light with the self-coherent camera

Context. In the context of direct imaging of exoplanets, coronagraphs are commonly proposed to reach the required very high contrast levels. However, wavefront aberrations induce speckles in their focal plane and limit their performance. Aims. An active correction of these wavefront aberrations using a deformable mirror upstream of the coronagraph is mandatory. These aberrations need to be calibrated and focal-plane wavefront-sensing techniques in the science channel are being developed. One of these, the self-coherent camera, of which we present the latest laboratory results. Methods. We present here an enhancement of the method: we directly minimized the complex amplitude of the speckle field in the focal plane. Laboratory tests using a four-quadrant phase-mask coronagraph and a 32x32 actuator deformable mirror were conducted in monochromatic light and in polychromatic light for different bandwidths. Results. We obtain contrast levels in the focal plane in monochromatic light better than 3.10^-8 (RMS) in the 5 - 12 {\lambda}/D region for a correction of both phase and amplitude aberrations. In narrow bands (10 nm) the contrast level is 4.10^-8 (RMS) in the same region. Conclusions. The contrast level is currently limited by the amplitude aberrations on the bench. We identified several improvements that can be implemented to enhance the performance of our optical bench in monochromatic as well as in polychromatic light.

Transcranial phase aberration correction using beam simulations and MR‐ARFI

Transcranial magnetic resonance-guided focused ultrasound surgery is a noninvasive technique for causing selective tissue necrosis. Variations in density, thickness, and shape of the skull cause aberrations in the location and shape of the focal zone. In this paper, the authors propose a hybrid simulation-MR-ARFI technique to achieve aberration correction for transcranial MR-guided focused ultrasound surgery. The technique uses ultrasound beam propagation simulations with MR Acoustic Radiation Force Imaging (MR-ARFI) to correct skull-caused phase aberrations. Skull-based numerical aberrations were obtained from a MR-guided focused ultrasound patient treatment and were added to all elements of the InSightec conformal bone focused ultrasound surgery transducer during transmission. In the first experiment, the 1024 aberrations derived from a human skull were condensed into 16 aberrations by averaging over the transducer area of 64 elements. In the second experiment, all 1024 aberrations were applied to the transducer. The aberrated MR-ARFI images were used in the hybrid simulation-MR-ARFI technique to find 16 estimated aberrations. These estimated aberrations were subtracted from the original aberrations to result in the corrected images. Each aberration experiment (16-aberration and 1024-aberration) was repeated three times. The corrected MR-ARFI image was compared to the aberrated image and the ideal image (image with zero aberrations) for each experiment. The hybrid simulation-MR-ARFI technique resulted in an average increase in focal MR-ARFI phase of 44% for the 16-aberration case and 52% for the 1024-aberration case, and recovered 83% and 39% of the ideal MR-ARFI phase for the 16-aberrations and 1024-aberration case, respectively. Using one MR-ARFI image and noa priori information about the applied phase aberrations, the hybrid simulation-MR-ARFI technique improved the maximum MR-ARFI phase of the beam's focus.

Adaptive phase aberration correction based on imperialist competitive algorithm

We investigate numerically the feasibility of phase aberration correction in a wavefront sensorless adaptive optical system, based on the imperialist competitive algorithm (ICA). Considering a 61-element deformable mirror (DM) and the Strehl ratio as the cost function of ICA, this algorithm is employed to search the optimum surface profile of DM for correcting the phase aberrations in a solid-state laser system. The correction results show that ICA is a powerful correction algorithm for static or slowly changing phase aberrations in optical systems, such as solid-state lasers. The correction capability and the convergence speed of this algorithm are compared with those of the genetic algorithm (GA) and stochastic parallel gradient descent (SPGD) algorithm. The results indicate that these algorithms have almost the same correction capability. Also, ICA and GA are almost the same in convergence speed and SPGD is the fastest of these algorithms.

3-D Transcranial Ultrasound Imaging with Bilateral Phase Aberration Correction of Multiple Isoplanatic Patches: A Pilot Human Study with Microbubble Contrast Enhancement

With stroke currently the second-leading cause of death globally, and 87% of all strokes classified as ischemic, the development of a fast, accessible, cost-effective approach for imaging occlusive stroke could have a significant impact on health care outcomes and costs. Although clinical examination and standard computed tomography alone do not provide adequate information for understanding the complex temporal events that occur during an ischemic stroke, ultrasound imaging is well suited to the task of examining blood flow dynamics in real time and may allow for localization of a clot. A prototype bilateral 3-D ultrasound imaging system using two matrix array probes on either side of the head allows for correction of skull-induced aberration throughout two entire phased array imaging volumes. We investigated the feasibility of applying this custom correction technique in five healthy volunteers with Definity microbubble contrast enhancement. Subjects were scanned simultaneously via both temporal acoustic windows in 3-D color flow mode. The number of color flow voxels above a common threshold increased as a result of aberration correction in five of five subjects, with a mean increase of 33.9%. The percentage of large arteries visualized by 3-D color Doppler imaging increased from 46% without aberration correction to 60% with aberration correction.

Phase aberration correction by correlation in digital holographic adaptive optics

We present a phase aberration correction method based on the correlation between the complex full-field and guide-star holograms in the context of digital holographic adaptive optics (DHAO). Removal of a global quadratic phase term before the correlation operation plays an important role in the correction. Correlation operation can remove the phase aberration at the entrance pupil plane and automatically refocus the corrected optical field. Except for the assumption that most aberrations lie at or close to the entrance pupil, the presented method does not impose any other constraints on the optical systems. Thus, it greatly enhances the flexibility of the optical design for DHAO systems in vision science and microscopy. Theoretical studies show that the previously proposed Fourier transform DHAO (FTDHAO) is just a special case of this general correction method, where the global quadratic phase term and a defocus term disappear. Hence, this correction method realizes the generalization of FTDHAO into arbitrary DHAO systems. The effectiveness and robustness of this method are demonstrated by simulations and experiments.

Pitch-catch phase aberration correction of multiple isoplanatic patches for 3-D transcranial ultrasound imaging

Having previously presented the ultrasound brain helmet, a system for simultaneous 3-D ultrasound imaging via both temporal bone acoustic windows, the scanning geometry of this system is utilized to allow each matrix array to serve as a correction source for the opposing array. Aberration is estimated using cross-correlation of RF channel signals, followed by least mean squares solution of the resulting overdetermined system. Delay maps are updated and real-time 3-D scanning resumes. A first attempt is made at using multiple arrival time maps to correct multiple unique aberrators within a single transcranial imaging volume, i.e., several isoplanatic patches. This adaptive imaging technique, which uses steered unfocused waves transmitted by the opposing, or beacon, array, updates the transmit and receive delays of 5 isoplanatic patches within a 64° x 64° volume. In phantom experiments, color flow voxels above a common threshold have also increased by an average of 92%, whereas color flow variance decreased by an average of 10%. This approach has been applied to both temporal acoustic windows of two human subjects, yielding increases in echo brightness in 5 isoplanatic patches with a mean value of 24.3 ± 9.1%, suggesting that such a technique may be beneficial in the future for performing noninvasive 3-D color flow imaging of cerebrovascular disease, including stroke.