Horner’s syndrome occurs secondary to paresis of the oculo-sympathetic pathway and classically presents with the triad of ptosis, miosis, and anhidrosis. Sympathetic innervation to the eye involves a long and tortuous course requiring three separate neuronal junctions to complete the pathway. An insult along any part of this pathway will result in the constellation of findings characteristic of the syndrome. Herein, we report the case of a 63-year-old male who presented with ptosis and anisocoria of the left eye following hospitalization for COVID-19 infection. A diagnosis of Horner’s syndrome was confirmed with pharmacological testing, and further evaluation identified the underlying etiology. We will include an overview of the clinical presentation, various etiologies, diagnosis, and management of Horner’s syndrome. CE Notification: This article is available as a COPE accredited CE course. You may take this course for 1-hour credit. Read the article and take the qualifying test to earn your credit. Click here to Enroll (https://www.crojournal.com/case-report-giant-cell-arteritis-presenting-with-6th-nerve-palsy-without-ischemic-optic-neuropathy) Please check COPE course expiry date prior to enrollment. The COPE course test must be taken before the course expiry date.