Abstract
Mathematical and computational modeling has been a great ally in the development of new drugs. It helps by providing preliminary results that ultimately guide the path that the tests should take. Thus, the objective of this work was to develop the PharmaLab computational tool, which simulates the pharmacological action in the mouse ventricular myocyte using the mathematical model of Mullins & Bondarenko (2013). Having as one of the main differentials the integration with a model for the force of contraction, at PharmaLab it is possible to perform pharmacological tests by changing parameters of the mathematical model and registering drugs to be used in the simulations. The computational tool has its own interface for plotting results and support material for educational use. As a demonstration of the tool, a validation was performed, comparing simulations with experimental data for the drug Niferidil and two “in silico” tests: SS-68 correcting the “Catecholaminergic Polymorphic Ventricular Tachycardia” (CPVT) and Niferidil correcting the Short QT Syndrome (SQTS). The drugs showed good results in the correction of arrhythmias. Finally, it can be concluded that the PharmaLab computational tool has resources for use in both research and teaching.
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