Counterfeiting and piracy are one of the biggest issues of the global economy in the last two decades, facing all industrial sectors, including pharmaceutical industry. Counterfeiting of medicines is a growing phenomenon affecting all type of medicines including both innovative and generic and represents a serious public health problem and a problem of the trade competition as an intellectual property right infringement. In order to combat this problem, anti-counterfeit regulatory activities are undertaken on a global level through establishment of legislation, strengthening the regulatory activities, development of mechanisms for effective collaboration between the stakeholders on national and international level and communication for raising public awareness regarding the risk of using counterfeited medicines. The role of the pharmaceutical manufacturers, wholesalers and retailers in the fight against counterfeited medicines is essential for securing the supply chain and providing quality, safety and efficacy of the medicines that reach the patients from one side and for protecting their brands and their profit from the other side.