Field Of Pharmaceutical Research Research Articles

Exploring the Versatility of Microemulsions in Cutaneous Drug Delivery: Opportunities and Challenges.

Microemulsions are novel drug delivery systems that have garnered significant attention in the pharmaceutical research field. These systems possess several desirable characteristics, such as transparency and thermodynamic stability, which make them suitable for delivering both hydrophilic and hydrophobic drugs. In this comprehensive review, we aim to explore different aspects related to the formulation, characterization, and applications of microemulsions, with a particular emphasis on their potential for cutaneous drug delivery. Microemulsions have shown great promise in overcoming bioavailability concerns and enabling sustained drug delivery. Thus, it is crucial to have a thorough understanding of their formulation and characterization in order to optimize their effectiveness and safety. This review will delve into the different types of microemulsions, their composition, and the factors that affect their stability. Furthermore, the potential of microemulsions as drug delivery systems for skin applications will be discussed. Overall, this review will provide valuable insights into the advantages of microemulsions as drug delivery systems and their potential for improving cutaneous drug delivery.

Validation of Artificial Intelligence Containing Products Across the Regulated Healthcare Industries.

The introduction of artificial intelligence / machine learning (AI/ML) products to the regulated fields of pharmaceutical research and development (R&D) and drug manufacture, and medical devices (MD) and in vitro diagnostics (IVD), poses new regulatory problems: a lack of a common terminology and understanding leads to confusion, delays and product failures. Validation as a key step in product development, common to each of these sectors including computerized systems and AI/ML development, offers an opportune point of comparison for aligning people and processes for cross-sectoral product development. A comparative approach, built upon workshops and a subsequent written sequence of exchanges, is summarized in a look-up table suitable for mixed-teams work. 1. A bottom-up, definitions led, approach which leads to a distinction between broad vs narrow validation, and their relationship to regulatory regimes. 2. Common basis introduction to the primary methodologies for software validation, including AI-containing software validation. 3. Pharmaceutical drug development and MD/IVD-specific perspectives on compliant AI software development, as a basis for collaboration. Alignment of the terms and methodologies used in validation of software products containing artificial intelligence/machine learning (AI/ML) components across the regulated industries of human health is a vital first step in streamlining processes and improving workflows.

A Review on Physicochemical Properties of Polymers Used as Filaments in 3D-Printed Tablets.

Three-dimensional (3D) printing technology has presently been explored widely in the field of pharmaceutical research to produce various conventional as well as novel dosage forms such as tablets, capsules, oral films, pellets, subcutaneous implants, scaffolds, and vaginal rings. The use of this innovative method is a good choice for its advanced technologies and the ability to make tailored medicine specifically for individual patient. There are many 3D printing systems that are used to print tablets, implants, and vaginal rings. Among the available systems, the fused deposition modeling (FDM) is widely utilized. The FDM has been regarded as the best choice of printer as it shows high potential in the production of tablets as a unit dose in 3D printing medicine manufacturing. In order to design a 3D-printed tablet or other dosage forms, the physicochemical properties of polymers play a vital role. One should have proper knowledge about the polymer's properties so that one can select appropriate polymers in order to design 3D-printed dosage form. This review highlighted the various physicochemical properties of polymers that are currently used as filaments in 3D printing. In this manuscript, the authors also discussed various systems that are currently adopted in the 3D printing.

Biomimetic synthesis and characterization of silver nanoparticles from Dipterygium glaucum extract and its anti-cancerous activities

The pharmaceutical research field dramatically benefits from using silver nanoparticles (AgNPs). In particular, AgNPs fabricated by plant extracts significantly impact biological processes, including antioxidant, antibacterial, and anticancer effects. In light of this, the current study examined the impact of AgNPs synthesized from Dipterygium glaucum Decne. plant extract on the three most prevalent human cancer cell lines, including HepG2, MCF-7, and HeLa. UV–visible spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) characterized these nanoparticles. The approach was very efficient, cost-effective, and eco-friendly. These findings indicate that AgNPs exhibited exceptional cytotoxicity against all the cell lines, indicating a high therapeutic index value. In a concentration-dependent manner, these AgNPs induced cytotoxic activity against HepG-2 liver (IC50 2.21 µg/ml), HeLa cervical (IC50 2.14 µg/ml), and MCF-7 breast (IC50 1.1 µg/ml) cancer cell lines.

Novel Therapeutic Approaches Targeting Post-Translational Modifications in Lung Cancer.

Lung cancer is one of the most common cancers worldwide. It consists of two different subtypes: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Despite novel therapeutic options such as immunotherapy, only 20% of lung cancer patients survive the disease after five years. This low survival rate is due to acquired drug resistance and severe off-target effects caused by currently used therapies. Identification and development of novel and targeted therapeutic approaches are urgently required to improve the standard of care for lung cancer patients. Here, we describe the recent development of novel drug-delivery approaches, such as adenovirus, lipid nanoparticles, and PROTACs, that have been tested in clinical trials and experimentally in the context of fundamental research. These different options show that it is now possible to target protein kinases, phosphatases, ubiquitin ligases, or protein modifications directly in lung cancer to block disease progression. Furthermore, the recent acceptance of RNA vaccines using lipid nanoparticles has further revealed therapeutic options that could be combined with chemo-/immunotherapies to improve current lung cancer therapies. This review aims to compare recent advances in the pharmaceutical research field for the development of technologies targeting post-translational modifications or protein modifiers involved in the tumorigenesis of lung cancer.

Efficient full-length IgG secretion and sorting from single yeast clones in droplet picoreactors.

The search for new antibodies is a major field of pharmaceutical research that remains lengthy and costly due to the need for successive library screenings. Existing in vitro and in vivo antibody discovery processes require that libraries are repeatedly subcloned to switch the antibody format or the secretory host, a resource-intensive process. There is an urgent need for an antibody identification platform capable of screening large antibody libraries in their final soluble format. Previous attempts to develop such a platform have struggled to combine large antibody libraries with screening of high specificity, while retaining sufficient library diversity coverage (ability to detect rare events). Here, we describe a new antibody screening platform based on the encapsulation of antibody secreting yeast cells into picoreactor droplets. We developed and optimized a Yarrowia lipolytica yeast strain capable of growing and secreting full-length human IgGs in picoreactors, and applied a microfluidics-based high-throughput screening approach to sort and recover target-specific antibody-secreting yeasts. Critically, the direct recovery of secretory yeasts allows for downstream screening and antibody characterization, without the need to reformat or subclone the coding sequences. We successfully increased the diversity coverage of sorting the antibody library without compromising sorting specificity by developing a new fluorescence signal processing methodology. By combining this drastically enhanced sorting efficiency with the high-throughput capability of droplet microfluidics, and the rapid growth of Y. lipolytica, our new platform is capable of screening millions of antibodies per day and enriching for target-specific ones in 4 days. This platform will enable the efficient screening of antibody libraries in a variety of contexts, including primary screening of synthetic libraries, affinity maturation, and identification of multi-specific or cross-reactive antibodies.

Enhancing oral bioavailability of andrographolide via sodium dodecyl sulfate and D-α-Tocopherol polyethylene glycol 1000 succinate copolymer modified nanocrystals

Nanocrystal technology is a common strategy to enhance the oral bioavailability of poorly-soluble drugs, and how to enlarge the enhancing ability on oral absorption via nanocrystals has become a pharmaceutical research field. In this study, we selected andrographolide (ADR), a typical poorly-soluble drug, as the model drug, and employed sodium dodecyl sulfate and D-ɑ-Tocopherol polyethylene glycol 1000 succinate copolymer (SDS-TPGS) to construct novel SDS-TPGS modified andrographolide nanocrystals (S-TANs). We found that the particle sizes of SDS/TPGS physical mixture modified nanocrystals (STANs) were about 553.4 ± 4.1 nm, while that of SDS-TPGS modified nanocrystals (S-TANs) were 604.6 ± 5.7 nm. During the production process of nanocrystals, the crystallinity of ADR was slightly decreased. Nanocrystals enhanced the saturation solubility of ADR, and improved oral absorption, Cmax and AUC0-∞ of S-TANs was about 2.10 and 1.24 fold increased, STAN about 2.63, 2.97 fold. In a Real-time distribution study, we found the distribution time of andrographolide, SDS and TPGS in SDS/TPGS physical mixture modified nanocrystals system varies widely, while the distribution times of these materials were similar in SDS-TPGS copolymer modified nanocrystals system. These results indicated that modified with functional stabilizer was an efficient strategy to enlarge the enhancing ability on oral absorption of nanocrystals, and synthesized copolymer containing different functional stabilizers showed higher ability on enhancing oral bioavailability than physical mixtures.

Chrysin: A polyedric flavone as a tool to explore new phytotherapeutic applications and drug design.

In the field of pharmaceutical research, a branch that has become more and more interesting is phytochemistry. Among phytochemicals, flavonoids have been studied a lot over the past 30 years. This review summarizes the chemical characteristics, metabolism, applications, and toxicity of a particular flavonoid, chrysin, recorded in the last 10 years and supported by solid biological assays. Furthermore, this review highlights some derivatives of chrysin investigated to obtain more bioavailable molecules that maintain or improve chrysin's bioactivities, enclosing a chrysin patent section, as well.

A Noval Approach on Triangular Fuzzy Unisum Labeling in Pharmaceutical Research

Triangular fuzzy graph labeling is used to create a networking model in the field of pharmaceutical research which will provide a structure for taking advantage of proposed medicines and segregate suitable compounds in case of vagueness of dataset of medicines. Especially all acyclic fuzzy graphs are most commonly used to represent a pharmaceutical model. In this paper,Triangular fuzzy unisum labeling has been introduced which is used to attain the accuracy value in the consecutive distinct edge labeling. Also the researcher have been shown the existence of unisum labeling in triangular fuzzy bistar graph 〖 B〗_(m,n):(σ,μ) ∀ m,n . Also the researcher have been proved the results such that every triangular fuzzy bistar graph admits the condition of unisum labeling which is leading to obtain the triangular fuzzy graceful bistar graph.

Modulation of the structural and functional properties of α1-antitrypsin by interaction with flavonoid luteolin

α1-antitrypsin (A1AT) is a circulating serine protease inhibitor and an acute phase reactant, the deficiency of which can lead to liver failure and chronic lung disease. Flavonoid treatment may induce changes in α1-antitrypsin production in some human cells. The purpose of this study is to investigate the properties of the A1AT protein that interacts with the flavonoid luteolin, which exhibits numerous properties, including antioxidant properties. For this purpose, multi-spectroscopic (UV-Vis spectroscopy, fluorescence and FRET) methods and molecular docking were used. The intrinsic fluorescence of A1AT was quenched by luteolin through a static mechanism. Luteolin binds to one site of the A1AT protein, with a moderate binding constant, and the binding process was driven by entropy and hydrophobic interactions. Hydrophobicity around Trp decreased as a result of luteolin binding to the A1AT site and FRET occurred at a distance of 3.11 nm. Under the action of temperature, the stability of A1AT structure was decreased by the presence of luteolin. Molecular docking confirmed that luteolin binds to one site, with a moderate affinity. The results would give a better understanding of the functional changes that occurred in the structure of A1AT induced by luteolin binding, which may have implications in the field of pharmaceutical research. Communicated by Ramaswamy H. Sarma

Advancement of Near Infrared techniques in diagnosis and treatment of cancer

Near-Infrared photoimmunotheraphy (NIR-PIT) is newly developed therapy for cancer treatment, by using a specific monoclonal antibody (mAb) conjugated to a photoactive agent i.e. IRDye 700DX. In this technique, the conjugate of specific monoclonal antibody - photoactive agent is administered intravenously to cancer patient. When NIR light is applied, the monoclonal antibody - photoactive agent conjugate (APC) is excited and selectively kill the cancer cell without harming neighbouring normal cell. NIR light alters the chemical structure of APC and damages the cancer cell membrane. For the diagnosis of tumor, it is possible to observe the movements of erythrocyte in tissues by using diffuse correlation spectroscopy (DCS). DCS flow measurements are carried out by observing photon speckle variations induced by moving tissue scattering. Another diagnostic tool is Near-infrared spectroscopy (NIRS), which is based on endogenous chromophores difference between healthy tissue and cancer by using diagnostic indicator i.e. oxy-haemoglobin or deoxyhaemoglobin, lipid or water bands. NIRS is being used in a variety of biological and pharmaceutical research fields, including brain imaging, cardiovascular radiology, formulation and quality/process control, and even clinical trial. In this review article, we describe the Near-Infrared photoimmunotheraphy (NIR-PIT) with its mechanism, role of DCS & NIRS in cancer diagnosis and various application of NIR-PIT.
 Keyword: Near-infrared immunotherapy (NIR-PIT); diffuse correlation spectroscopy (DCS); Near-infrared spectroscopy (NIRS); Cancer treatment; Cancer diagnosis.

Isolation, Identification and Analysis of Novel Metabolites from Soil Samples (Microbial Co Culture) of Cardamom Plantations Western Ghats, India

Growing microbial resistance in clinically important microorganisms are of immediate interest in the field of pharmaceutical research. Plants, animals and microbes have been source of various antibiotics for decades. Research on these aspects is extensive and newer compounds have been identified from both terrestrial and marine sources. In recent times, there is emergence of co-culture technique that has proved to produce novel compounds due to the stress induced activity when two strains are grown in the same medium with competition for survival. Studies have shown successful outcomes in co-culture of organisms of the same species including Bacteria-Bacteria, Fungi-Fungi and Fungi-Bacteria. This study aimed at isolating specific microbes from the soil of Cardamom plantation from the Western ghats and obtaining pure culture of Pseudomonas sp. The isolated strains were subjected to morphological and molecular characterization by 16s rRNA sequencing. These strains were further co cultured as a combination to isolate the stress induced metabolites that would be produced due to competition. The extraction and the isolation of the crude metabolite from the co-culture were further evaluated for antimicrobial activity against human pathogenic bacteria. The study revealed the isolation and species identification of bacterial strains Pseudomonas nitritireducens and Micrococcus endophyticus from the soil samples. The co-cultured bacterial strains on extraction by organic solvents of hexane and dichloromethane showed promising activity against both gram positive and gram-negative bacteria on comparison with the other extracts. Further qualitative analysis revealed the presence of saponins and alkaloids in the active extracts.

Computer Aided Drug Design, 3D Printing, and Virtual Screening: Recent Advancement and Applications in the Pharma Field

Drug discovery in pharmaceutical research is a very time taking process. It takes around about 10 to 14 years reached to clinical trial. Chances of discovery of novel molecule reached to clinical trial are very less. Also, it takes billion of investment. Biomedical engineering with new technologies is the answer to these problems. The purpose of this review is to focus on the applications of new technologies like computer-aided drug design, virtual screening, molecular docking, 3D printing, etc. in the field of pharmaceutical research, drug delivery system, and drug discovery. So it is very important for all the researchers and pharmacy departments to be aware of the benefits or applications of these modern technologies. These modern technologies are very useful for pharmaceutical research including pharmacokinetics or pharmacodynamics modeling, optimization of the drug dosage form, and drug delivery system. The current progress of docking-based virtual screening leads to finding out the new target molecule and designing the molecule by using computer-aided drug design and ultimately manufacturing or customization of the dosage form by using 3D printing may finally lead to the become a reality.

Irkutsk institute of chemistry named after A.E. Favorskii SB RAS – achievements in the field of pharmaceutical research

The data showing on an example only of one scientific school potential of a domestic chemic-pharmaceutical science are resulted. It is marked. Presence of two mainstreams — creation of original domestic preparations and food additives, and also development of medicines-generics taking place in Irkutsk institute of chemistry of the Russian Academy of Science. Affirms, that development of these most perspective directions keeps on enthusiasm devoted to the business and school experts of the highest class. It is recommended to integrate efforts of all experts within the limits of RAS.

The Treatment of Alzheimer’s Disease through Molecular Docking Studies using Phyltetralin against Kallikrein_6: A Bioinformatic Approach

Alzheimer's disease (AD) is a neurodegenerative disease that generally begins leisurely and gets worse with time. Alzheimer’s disease (AD) dementia is the specific beginning of age-related declination of cognitive abilities and function, which eventually leads to death. Alzheimer’s disease (AD) is one of the neurodeteriorating disorders which is one of the mostcritical complications that our current health care system faces. The phenomenon of molecular docking has progressively become a strong tool in the field of pharmaceutical research including drug discovery. The aim of the presentin silico study was to inhibit the expression of KLK-6 (kallikrein-6) which is a target or receptor protein by its interaction with three distinct secondary metabolites for treating Alzheimer's disease (AD) through molecular docking. Methods: The in-silico study was based on molecular docking. Docking was executed amidst ligands- Quercetin (CID: 5280343), Ricinoleic Acid (CID: 643684), Phyltetralin (CID: 11223782), and the target or receptor protein Kallikrein-6 (PDB ID: 1LO6). The protein and the ligands were downloaded in the required format. Through PyRx, the ligands were virtually screened after importing them in the PyRx window. The results of PyRx and SwissADME were analyzed and the best ligand was finalized. Among the three, Phyltetralin was the best ligand contrary to KLK-6 having minimum binding energy and it was following Lipinski’s five rules along with 0 violations. Results: The final docking was carried out between Phyltetralin and KLK-6 through AutoDock Vina. The outcome showed 9 poses with distinct binding energy, RSMD LB (root mean square deviation lower bound) and RSMD UB (root mean square deviation upper bound). With the help of PyMOL which is an open-access tool for molecular visualization, the interaction amidst Phyltetralin and KLK-6 can be visualized. Conclusion: Based on this in silico study it can be concluded that KLK-6 (kallikrein-6) which is responsible for causing AD can be inhibited by ligand Phyltetralin and for the treatment of AD, phyltetralin might act as a potential drug. Thus, in future studies, Phyltetralin from natural sources can prevent Alzheimer's disease and can be proved as a promising and efficient drug for treating Alzheimer's disease.

Progress in the Application of Nano- and Micro-based Drug Delivery Systems in Pulmonary Drug Delivery

Abstract Nanotechnology is associated with the development of particles in the nano-size range that can be used in a wide range of applications in the medical field. It has gained more importance in the pharmaceutical research field particularly in drug delivery, as it results in enhanced therapeutic drug performance, improved drug solubility, targeted drug delivery to the specific sites, minimized side effects, and prolonged drug retention time in the targeted site. To date, the application of nanotechnology continues to offer several benefits in the treatment of various chronic diseases and results in remarkable improvements in treatment outcomes. The use of nano-based delivery systems such as liposomes, micelles, and nanoparticles in pulmonary drug delivery have shown to be a promising strategy in achieving drug deposition and maintained controlled drug release in the lungs. They have been widely used to minimize the risks of drug toxicity in vivo. In this review, recent advances in the application of nano- and micro-based delivery systems in pulmonary drug delivery for the treatment of various pulmonary diseases, such as lung cancer, asthma, and chronic obstructive pulmonary disease, are highlighted. Limitations in the application of these drug delivery systems and some key strategies in improving their formulation properties to overcome challenges encountered in drug delivery are also discussed.

Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes

Mushrooms have been used as a primary source of medicines since ancient times due to the presence of bioactive compounds. Enzyme inhibition is an important field of pharmaceutical research that provides insight into the discovery of a large variety of drugs that are useful in treating many diseases. The inhibitory activities of the hexane and methanol extracts of twenty-four medicinal mushrooms on α-amylase and α-glucosidase enzymes related to type 2 diabetes were evaluated in this study. Among all studied mushroom extracts, C. rutilus hexane extract (IC50: 0.05±0.01 mg/mL) demonstrated the highest inhibitory activity on α-amylase while P. ostreatus hexane (IC50: 0.10±0.01 mg/mL) showed the highest inhibitory activity on α-glucosidase. The hexane extracts of C. rutilus (98.81±0.01 %), G. adspersum (96.96±0.47 %), G. sepiarium (96.89±1.01 %), and S. granulatus (97.74±0.27 %) displayed higher inhibitory activity on α-amylase enzyme than acarbose at 1.00 mg/mL concentration. Also, the hexane extracts of P. ostreatus (IC50: 0.10±0.01 mg/mL), M. procera (IC50: 0.11±0.01 mg/mL), P. schweinitzii (IC50: 0.14±0.01 mg/mL), L. gentianeus (IC50: 0.22±0.02 mg/mL), P. pini (IC50: 0.22±0.03 mg/mL) and the methanol extracts of T. pubescens (IC50: 0.12±0.02 mg/mL) and G. adspersum (IC50: 0.20±0.04 mg/mL) showed higher inhibitory activity on α-glucosidase enzyme than acarbose (IC50: 0.37±0.01 mg/mL). This study with the reported results supported the use of mushrooms in the pharmaceutical industries as natural antidiabetic agents through key enzyme inhibition.

Smart TLC–densitometric methods for determination of ophthalmic ternary mixture containing chloramphenicol in the presence of its synthetic precursor: Comparative eco-scaling for greenness assessment

Green analytical methods have gained a growing interest in the field of pharmaceutical research to reduce impacts on the environment and enhance analysts’ health safety. Chloramphenicol (CHL), dexamethasone sodium phosphate (DSP) and tetrahydrozoline HCl (THZ) form an ophthalmic ternary mixture that is co-formulated for conjunctivitis treatment. In the present work, for time saving and higher sensitivity, two green thin-layer chromatography (TLC) methods were developed for the determination of this ophthalmic ternary mixture in the absence or presence of p-nitroacetophenone (PNA), a synthetic precursor of chloramphenicol. In both proposed methods, silica gel 60 F254 plates were used as the stationary phase. The mobile phase used for method (A) was ethanol‒water‒ammonia (7.0:2.5:0.5, V/V), while, for method (B), acetonitrile‒water‒ammonia (10.0:3.0:0.5, V/V) was used as the mobile phase. TLC separation was followed by quantitative determination of the aforementioned drugs at wavelengths 242.0 nm and 220.0 nm. Both methods were validated in compliance with the International Conference on Harmonisation (ICH) guidelines, where both methods were found to be reliable, reproducible, and selective. Statistical comparison of the developed methods was done with a reported high-performance liquid chromatography (HPLC) method where no significant difference was found. Analytical eco-scaling depends on penalty point which was calculated to be 92, 88 and 87 for methods A, B and the reported HPLC, respectively, suggesting that the proposed methods are eco-friendlier with penalty point scoring very high on the scale than the reported one.

Substituted 6,7-dimethoxy-5-oxo-2,3,5,9b-tetrahydrothiazolo[2,3-a]isoindole- 3-1,1-dioxide Derivatives with Antimicrobial Activity and Docking Assisted Prediction of the Mechanism of their Antibacterial and Antifungal Properties.

Although a great number of the targets of antimicrobial therapy have been achieved, it remains among the first fields of pharmaceutical research, mainly because of the development of resistant strains. Docking analysis may be an important tool in the research for the development of more effective agents against specific drug targets or multi-target agents 1-3. In the present study, based on docking analysis, ten tetrahydrothiazolo[2,3-a]isoindole derivatives were chosen for the evaluation of the antimicrobial activity. All compounds showed antibacterial activity against eight Gram-positive and Gram-negative bacterial species being, in some cases, more potent than ampicillin and streptomycin against all species. The most sensitive bacteria appeared to be S. aureus and En. Cloacae, while M. flavus, E. coli and P. aeruginosa were the most resistant ones. The compounds were also tested for their antifungal activity against eight fungal species. All compounds exhibited good antifungal activity better than reference drugs bifonazole (1.4 - 41 folds) and ketoconazole (1.1 - 406 folds) against all fungal species. In order to elucidate the mechanism of action, docking studies on different antimicrobial targets were performed. According to docking analysis, the antifungal activity can be explained by the inhibition of the CYP51 enzyme for most compounds with a better correlation of the results obtained for the P.v.c. strain (linear regression between estimated binding Energy and log(1/MIC) with R 2 =0.867 and p=0.000091 or R 2 = 0.924, p= 0.000036, when compound 3 is excluded.

An Overview on Promising Nanotechnological Approaches for the Treatment of Psoriasis.

Psoriasis is a chronic autoimmune disorder of the skin which is characterized by the reoccurring episodes of inflammatory lesions with a worldwide occurrence of around 2-5%. Psoriasis can be categorized as mild, moderate and severe conditions. In mild psoriasis, there is the formation of rashes, and when it becomes moderate, the skin turns scaly. In severe conditions, the red patches can be seen on the skin surface and the skin becomes itchy. The different treatment approaches include phototherapy, topical, oral and other systemic drug deliveries. Dermal treatment is now highly endorsed in topical indications for psoriatic patients, due to its higher penetration which can be achieved using pharmaceutical carriers. Though various conventional formulations are there, therapeutic benefits can be provided only to a limited extent. The objective of this review was to highlight newer biocompatible and biodegradable materials like phospholipids, and forefront drug delivery methods like liposomes, microemulsions, nanoemulsions, niosomes, ethosomes, etc. which has increased the possibility to improve the efficacy and safety of the topical products. Apart from this, many medicinal plants are available in nature that are used for treating skin diseases like psoriasis. The new trends in nanotechnology are marked by subsequent changes in the pharmaceutical research field. To safeguard the research works in the research field, various patents have been introduced, such as Glaxo Smith Kline (GSK 2981278) - RORγ antagonist, etc. The causes, pathophysiology and the herbal plants that are used in treating the disease are also discussed.