Objective To explore the status and influencing factors of optimistic coping among gynecologic tumor patients. Methods A total of 401 cases of gynecologic tumor patients was selected by the convenient sampling method. They were investigated by the Jalowiec Coping Scale, The Eysenck Personality Questionnaire-Revised Short Scale for Chinese, General Self-Efficacy Scale, Social Support Rating Scale. Results Optimistic coping in gynecologic tumor patients scored (1.61±0.36). The main influencing factors included residence place, education level, general self-efficacy score, personality trait score, they could explain 25.2% variation of optimistic coping of gynecological tumor patients. Conclusions Optimistic coping in gynecologic tumor patients scored is at a low level. Residence and education level, general self-efficacy score and personality trait score are important factors that affect the level of optimistic coping in gynecologic tumor inpatients. Medical staff should develop targeted nursing intervention measures, pay attention to mining and shaping patients' positive and optimistic personality traits, in order to improve patients' optimistic coping level, to achieve the ultimate goal of improving patients' quality of life nursing. Key words: Gynecologic neoplasms; Influencing factors; Optimistic; Coping