"Persons with Deafness are belonging to minority. They have their own belief, history, language and have unique communication skill. The present research intended to explore the perspectives of persons with Deafness about Deaf culture regards sign language as a vital aspect of communication and their social and economic challenges facing in daily life. The sample of the study consisted of 90 persons with Deafness registered at the 5 Deaf associations/Organizations of Odisha. A self-developed scale on perspective of deafness on deaf culture was used to assess the perspectives of deaf people about sign language and both social and economic challenges faced by them. Social Challenges includes- fear to deal with others, involve in social activities, discrimination feelings etc. Economic challenges include- unemployment, poor income, inability to buy appliances and software, lack of financial capabilities etc. The study results indicated that the perspectives of persons with Deafness about the Deaf culture among persons with deafness of different age groups with regard to using sign language show minimal variations among different age groups. There exist no significant differences among person with deafness and deaf cultures in facing social and economic challenges with respect to gender and demographic division. On the basis of findings, the recommendations were also suggested."